The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1. Determined by X-ray diffraction at 2.35 Å resolution. Released 17 Jan 2018.
Explore 6FAE in 3D Show helices and sheets RCSB PDB PDBe
6FAE contains 28 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 399-415 | 17 | |
| α-helix | 417-426 | 10 | |
| α-helix | 434-443 | 10 | |
| α-helix | 449-456 | 8 | |
| α-helix | 462-473 | 12 | |
| α-helix | 482-492 | 11 | |
| β-strand | 496-497 | 2 | 1 |
| α-helix | 499-516 | 18 | |
| α-helix | 518-522 | 5 | |
| α-helix | 528-545 | 18 | |
| α-helix | 551-553 | 3 | |
| α-helix | 555-556 | 2 | |
| α-helix | 557-563 | 7 | |
| β-strand | 568 | 1 | 2 |
| β-strand | 571 | 1 | 2 |
| α-helix | 572-573 | 2 | |
| α-helix | 575-587 | 13 | |
| α-helix | 592-594 | 3 | |
| α-helix | 597-606 | 10 | |
| β-strand | 607-608 | 2 | 3 |
| β-strand | 621-629 | 9 | 3 |
| β-strand | 643-649 | 7 | 3 |
| β-strand | 652-658 | 7 | 3 |
| β-strand | 668-675 | 8 | 3 |
| β-strand | 679-684 | 6 | 3 |
| β-strand | 692-697 | 6 | 3 |
| β-strand | 706-711 | 6 | 3 |
| α-helix | 715-741 | 27 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 16-23 | 8 | 4 |
| α-helix | 30-35 | 6 | |
| α-helix | 46-48 | 3 | |
| β-strand | 50-51 | 2 | 1 |
| β-strand | 53-57 | 5 | 4 |
| β-strand | 61-67 | 7 | 4 |
| α-helix | 75-78 | 4 | |
| α-helix | 79-82 | 4 | |
| β-strand | 87-93 | 7 | 4 |
| α-helix | 97-99 | 3 | |
| α-helix | 100-111 | 12 | |
| α-helix | 114-116 | 3 | |
| β-strand | 120-126 | 7 | 4 |
| α-helix | 136-142 | 7 | |
| α-helix | 145-147 | 3 | |
| β-strand | 153-158 | 6 | 4 |
| β-strand | 159 | 1 | 5 |
| α-helix | 160-162 | 3 | |
| β-strand | 164 | 1 | 5 |
| α-helix | 166-176 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| IQ motif and SEC7 domain-containing protein 2 | A | protein | 371 | Homo sapiens | Q5JU85 (AlphaFold model) |
| ADP-ribosylation factor 1 | B | protein | 213 | Homo sapiens | P84077 (AlphaFold model) |
>6FAE_1 IQ motif and SEC7 domain-containing protein 2 (chains A) MCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGV AHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQG EAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKL DDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLP HRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLV EMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK YRVESELEKQK
>6FAE_2 ADP-ribosylation factor 1 (chains B) MSSGASWSHPQFEKGGGSGGGSGGSAWSHPQFEKGSGVDLGTENLYFQSMRILMVGLDAA GKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGL IFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSL RHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
Targeting the Small GTPase Superfamily through their Regulatory Proteins. Gray, J.L., von Delft, F., Brennan, P. Angew Chem Int Ed Engl (2019). DOI 10.1002/anie.201900585 · PubMed
Other PDB entries of the same protein (UniProt Q5JU85 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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