6FNL: Ephrin B4 (EphB4) Receptor Protein Kinase

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase. Determined by X-ray diffraction at 1.27 Å resolution. Released 8 Aug 2018.

Method: X-ray diffraction
Resolution: 1.27 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,419
Mol. weight: 33.49 kDa
Released: 8 Aug 2018

Explore 6FNL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6FNL contains 17 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	609	1	1
α-helix	612-614	3
β-strand	615-623	9	1
β-strand	628-634	7	1
β-strand	642-649	8	1
α-helix	655-668	14
β-strand	676	1	2
α-helix	677-678	2
β-strand	679-683	5	1
β-strand	689-694	6	1
β-strand	700	1	2
α-helix	701-707	7
α-helix	714-733	20
α-helix	743-745	3
β-strand	746-748	3	2
β-strand	754-756	3	2
α-helix	784-786	3
α-helix	789-794	6
α-helix	799-814	16
α-helix	818-819	2
α-helix	826-834	9
α-helix	839-842	4
β-strand	846	1	3
α-helix	847-856	10
α-helix	861-863	3
α-helix	865-866	2
α-helix	867-879	13
α-helix	881-884	4
β-strand	887	1	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ephrin type-B receptor 4	A	protein	297	Homo sapiens	P54760 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6FNL_1 Ephrin type-B receptor 4 (chains A)
GMDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE
RQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI
QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET
SSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ
DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMIRNPASLKIVARENG

Primary citation

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. Troster, A., Heinzlmeir, S., Berger, B.T. et al. ChemMedChem (2018) 13:1629-1633. DOI 10.1002/cmdc.201800398 · PubMed

Other PDB entries of the same protein (UniProt P54760 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6FNK 1.05 Å, Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with a…
6FNM 1.16 Å, Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib
6FNJ 1.24 Å, Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with an isomer of…
6FNI 1.47 Å, Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with NVP-BHG712
2BBA 1.65 Å, Crystal Structure and Thermodynamic Characterization of the EphB4 Receptor in Complex…
2VWX 1.65 Å, ephB4 kinase domain inhibitor complex
2VWY 1.65 Å, ephB4 kinase domain inhibitor complex
2VWZ 1.65 Å, ephB4 kinase domain inhibitor complex
2VX1 1.65 Å, ephB4 kinase domain inhibitor complex
4BB4 1.65 Å, ephB4 kinase domain inhibitor complex
2XVD 1.7 Å, ephB4 kinase domain inhibitor complex
2X9F 1.75 Å, ephB4 kinase domain inhibitor complex

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