Crystal structure of the KAP1 RBCC domain in complex with the SMARCAD1 CUE1 domain. Determined by X-ray diffraction at 5.5 Å resolution. Released 26 Jun 2019.
Explore 6H3A in 3D Show helices and sheets RCSB PDB PDBe
6H3A contains 24 α-helices and 22 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 74-76 | 3 | |
| β-strand | 78-80 | 3 | 1 |
| β-strand | 86-88 | 3 | 1 |
| β-strand | 115 | 1 | 2 |
| β-strand | 124 | 1 | 2 |
| α-helix | 126-128 | 3 | |
| β-strand | 130-131 | 2 | 1 |
| α-helix | 132 | 1 | |
| β-strand | 208 | 1 | 3 |
| β-strand | 216 | 1 | 3 |
| β-strand | 219-221 | 3 | 4 |
| β-strand | 226-228 | 3 | 4 |
| α-helix | 230-234 | 5 | |
| β-strand | 243 | 1 | 4 |
| α-helix | 245-354 | 110 | |
| α-helix | 360-364 | 5 | |
| α-helix | 367-378 | 12 | |
| α-helix | 392-394 | 3 | |
| α-helix | 399-407 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 147-167 | 21 | |
| α-helix | 174-183 | 10 | |
| α-helix | 190-197 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 152-168 | 17 | |
| α-helix | 174-183 | 10 | |
| α-helix | 188-197 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 64 | 1 | 5 |
| β-strand | 71 | 1 | 5 |
| α-helix | 74-76 | 3 | |
| β-strand | 78-80 | 3 | 6 |
| β-strand | 86-88 | 3 | 6 |
| β-strand | 115 | 1 | 7 |
| β-strand | 124 | 1 | 7 |
| α-helix | 126-128 | 3 | |
| β-strand | 130-131 | 2 | 6 |
| α-helix | 132 | 1 | |
| β-strand | 208 | 1 | 8 |
| β-strand | 216 | 1 | 8 |
| β-strand | 219-221 | 3 | 9 |
| β-strand | 226-228 | 3 | 9 |
| β-strand | 242-243 | 2 | 9 |
| α-helix | 245-328 | 84 | |
| α-helix | 330-354 | 25 | |
| α-helix | 360-364 | 5 | |
| α-helix | 367-376 | 10 | |
| α-helix | 392-394 | 3 | |
| α-helix | 399-408 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing… | B, D | protein | 253 | Homo sapiens | Q9H4L7 (AlphaFold model) |
| Transcription intermediary factor 1-beta | A, F | protein | 382 | Homo sapiens | Q13263 (AlphaFold model) |
>6H3A_1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (chains B, D) SSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSEL EDLKDAKLQTLKELFPQRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSS EPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREV LKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSM KAQNGFNKKRKKN
>6H3A_2 Transcription intermediary factor 1-beta (chains A, F) GGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDG TVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEP LCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDC QLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQ VDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWA LESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAER PGTNSTGPAPMAPPRAPGPLSK
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 8 |
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. Lim, M., Newman, J.A., Williams, H.L. et al. Structure (2019) 27:1316-1325.e6. DOI 10.1016/j.str.2019.05.003 · PubMed
Other PDB entries of the same protein (UniProt Q9H4L7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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