6HBL: Echovirus 18 capsid protein 1

Echovirus 18 Open particle without three pentamers. Determined by electron microscopy at 3.7 Å resolution. Released 20 Mar 2019.

Method
Electron microscopy
Resolution
3.7 Å
Organism
Echovirus E18
Chains
45
Atoms
77,940
Mol. weight
1312.66 kDa
Released
20 Mar 2019

Explore 6HBL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6HBL contains 285 α-helices and 1,020 β-strands across 45 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains a, C, d, F, g, I, j, L, m, O, p, R, s, U and X: 7 helices, 20 β-strands

ElementResiduesLengthSheet
β-strand3002-3006591
α-helix30071
β-strand30141228
α-helix3021-30222
β-strand30231266
α-helix3030-30323
β-strand3039-30402266
α-helix3044-30474
β-strand3051-30522282
β-strand30581271
β-strand3070-30723282
β-strand30841283
β-strand3087-30882283
α-helix3100-31045
β-strand31081284
β-strand3111-312111282
β-strand31281285
β-strand3130-31367283
α-helix3141-31433
α-helix3146-31505
β-strand3153-31586283
β-strand3164-31663282
β-strand3169-31746282
β-strand3189-31957283
β-strand32001285
β-strand3209-322315282
β-strand32261284
Chains A, b, D, e, G, h, J, k, M, n, P, q, S, V and Y: 7 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix1059-10624
β-strand1066-107381
β-strand108612
α-helix1096-11027
β-strand1105-1119151
β-strand113613
β-strand1137-114262
α-helix1156-11583
β-strand1164-116522
α-helix11671
β-strand116813
α-helix1173-11742
β-strand1175-117841
β-strand1187-118821
β-strand119314
β-strand119415
β-strand120315
β-strand1213-121862
β-strand1229-123571
β-strand1237-124591
α-helix1247-12482
β-strand124916
α-helix1252-12532
β-strand127017
Chains B, c, i, K, l, N, r, W and Z: 5 helices, 31 β-strands
ElementResiduesLengthSheet
β-strand20141256
β-strand2017-20182257
β-strand2021-20222257
β-strand20251256
β-strand2032-20332258
α-helix2034-20363
β-strand20541259
β-strand2064-20652258
β-strand2069-20713260
β-strand2078-20825261
α-helix2084-20863
α-helix2090-20989
β-strand2102-21032259
β-strand2107-21115258
β-strand21191262
β-strand2121-21255261
β-strand21281261
β-strand21341263
β-strand21481264
β-strand21511264
α-helix21521
β-strand2153-21542261
β-strand21561265
β-strand21651263
β-strand21681265
β-strand217616
β-strand2186-21905261
β-strand2197-22004258
β-strand22101259
β-strand221514
β-strand2218-22247261
α-helix2227-22282
β-strand22291262
β-strand2238-22403260
β-strand2241-22455258
β-strand2250-22512259
Chains E, f, H, o, Q and T: 5 helices, 31 β-strands
ElementResiduesLengthSheet
β-strand20141218
β-strand2017-20182135
β-strand2021-20233135
β-strand20251218
β-strand2032-20332219
α-helix2034-20363
β-strand20541220
β-strand2064-20652219
β-strand2069-20713221
β-strand2078-20825222
α-helix2084-20863
α-helix2090-20989
β-strand2102-21032220
β-strand2107-21115219
β-strand21191223
β-strand2121-21255222
β-strand21281222
β-strand21341224
β-strand21481225
β-strand21511225
α-helix21521
β-strand2153-21542222
β-strand21561226
β-strand21651224
β-strand21681226
β-strand21761211
β-strand2186-21905222
β-strand2197-22004219
β-strand22101220
β-strand22151209
β-strand2218-22247222
α-helix2227-22282
β-strand22291223
β-strand2238-22403221
β-strand2241-22455219
β-strand2250-22512220

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Echovirus 18 capsid protein 1A, D, G, J, M, P, S, V, Y, b, e, h, k, n, qprotein287Echovirus E18Q8V635 (AlphaFold model)
Echovirus 18 capsid protein 2B, E, H, K, N, Q, T, W, Z, c, f, i, l, o, rprotein260Echovirus E18Q8V635 (AlphaFold model)
Echovirus 18 capsid protein 3C, F, I, L, O, R, U, X, a, d, g, j, m, p, sprotein239Echovirus E18Q8V635 (AlphaFold model)
Sequence of entity 1 (A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q), FASTA
>6HBL_1 Echovirus 18 capsid protein 1 (chains A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q)
GDNQDRTVANTQPSGPSNSTEIPALTAVETGHTSQVDPSDTIQTRHVVNFHSRSESTIEN
FMGRAACVFMDQYKINGEETSTDRFAVWTINIREMAQLRRKCEMFTYMRFDIEMTMVITS
CQDQGTILDQDMPVLTHQIMYVPPGGPIPAKVDGYEWQTSTNPSVFWTEGNAPPRISIPF
ISVGNAYSSFYDGWSHFTQDGTYGYTTLNAMGKLYIRHVNRSSPHQITSTIRVYFKPKHI
KAWVPRPPRLCPYINKRDVNFVVTEITDSRTSITDTPHPEHSVLATH
Sequence of entity 2 (B, E, H, K, N, Q, T, W, Z, c, f, i, l, o, r), FASTA
>6HBL_2 Echovirus 18 capsid protein 2 (chains B, E, H, K, N, Q, T, W, Z, c, f, i, l, o, r)
SPSAEECGYSDRVRSMTLGNSTITTQESANVVVGYGEWPSYLSDREATAEDQPTQPDVAT
CRFYTLESVQWEKTSPGWWWKFPEALKNMGLFGQNMHYHYLGRAGYTIHVQCNASKFHQG
CLLVVCVPEAEMGCADTDTTFPATELTTEDTPHVFTSDSITGKKVQAAVCNAGMGVGVGN
LTIFPHQWINLRTNNSATIVIPYINSVPMDNMFRHYNFTLMIIPFAPLNFTDGATAYVPI
TVTIAPMYAEYNGLRLASTQ
Sequence of entity 3 (C, F, I, L, O, R, U, X, a, d, g, j, m, p, s), FASTA
>6HBL_3 Echovirus 18 capsid protein 3 (chains C, F, I, L, O, R, U, X, a, d, g, j, m, p, s)
GVPVLNTPGSNQFLTSDDYQSPSAMPQFDETPEMHIPGEVRNLMEIAEVDSVVPVNNVTG
KTKSMDAYQIPVGTGNTDKTKPIFSFQMDPGYSSVLKRTLLGEMLNYYAHWSGSVKLTFL
FCGSAMATGKLLISYSPPGASVPTSRKDAMLGTHIVWDIGLQSSCVLCVPWISQSHYRMV
QQDPYTSAGYITCWYQTNIVVPPGAPTSCDVLCFASACNDFSVRLLRDTPFMAQPGKLQ

Primary citation

Enterovirus particles expel capsid pentamers to enable genome release. Buchta, D., Fuzik, T., Hrebik, D. et al. Nat Commun (2019) 10:1138-1138. DOI 10.1038/s41467-019-09132-x · PubMed

Other PDB entries of the same protein (UniProt Q8V635 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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