6I9M: JmjC domain-containing protein 5

JmjC domain-containing protein 5 (JMJD5) in complex with Mn and R-2-hydroxyglutarate. Determined by X-ray diffraction at 1.65 Å resolution. Released 4 Dec 2019.

Method: X-ray diffraction
Resolution: 1.65 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,194
Mol. weight: 30.34 kDa
Ligands: MN, 2HG
Released: 4 Dec 2019

Explore 6I9M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6I9M contains 12 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	183	1	1
β-strand	186-188	3	2
α-helix	192-195	4
α-helix	196-200	5
β-strand	206-209	4	2
α-helix	217-220	4
α-helix	223-230	8
β-strand	234-239	6	3
β-strand	249-254	6	3
α-helix	255-259	5
α-helix	260-264	5
β-strand	271-272	2	3
β-strand	273-276	4	2
α-helix	278-281	4
α-helix	283-288	6
α-helix	293-297	5
α-helix	302-304	3
β-strand	306-312	7	2
β-strand	317-321	5	1
β-strand	326-333	8	2
β-strand	336-341	6	1
α-helix	343-349	7
β-strand	351	1	4
β-strand	360	1	1
β-strand	361	1	4
α-helix	374-378	5
β-strand	382-386	5	1
β-strand	391-394	4	2
β-strand	399-404	6	1
β-strand	408-415	8	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
JmjC domain-containing protein 5	A	protein	256	Homo sapiens	Q8N371 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6I9M_1 JmjC domain-containing protein 5 (chains A)
MHHHHHHSSGVDLGTENLYFQSTVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQK
WSLEYIQEIAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFD
QIPELKQDISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRKYIRL
YSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAPFLSCILSPGEILFIPVKYWH
YVRALDLSFSVSFWWS

Ligands and cofactors

ID	Name	Formula	Copies
MN	Manganese (II) ion	Mn	1
2HG	(2R)-2-hydroxypentanedioic acid	C5 H8 O5	1

Water and common crystallization additives (TRS, GOL) are not listed.

Primary citation

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Islam, M.S., Markoulides, M., Chowdhury, R. et al. Sci Rep (2022) 12:20680-20680. DOI 10.1038/s41598-022-24154-0 · PubMed

Other PDB entries of the same protein (UniProt Q8N371 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4GJZ 1.05 Å, JMJD5 in complex with 2-oxoglutarate
6F4Q 1.12 Å, Human JMJD5 (Q275C) in complex with Mn(II), NOG and RPS6-A138C (129-144) (complex-2)
6F4T 1.22 Å, Human JMJD5 (W414C) in complex with Mn(II), NOG and RCCD1 (139-143) (complex-5)
4GJY 1.25 Å, JMJD5 in complex with N-Oxalylglycine
6F4O 1.28 Å, Human JMJD5 in complex with Mn(II) and Succinate.
6F4R 1.3 Å, Human JMJD5 (N308C) in complex with Mn(II), NOG and RCCD1 (139-143) (complex-3)
6I9N 1.36 Å, JmjC domain-containing protein 5 (JMJD5) in complex with Mn and L-2-hydroxyglutarate
6F4P 1.45 Å, Human JMJD5 in complex with MN, NOG and RPS6 (129-144) (complex-1)
6F4S 1.46 Å, Human JMJD5 (N308C) in complex with Mn(II), 2OG and RCCD1 (139-143) (complex-4)
7UQ3 1.49 Å, JmjC domain-containing protein 5 (JMJD5) in complex with Mn and…
6I9L 1.53 Å, JmjC domain-containing protein 5 (JMJD5) in complex with Mn and…
4QU1 1.57 Å, Crystal structure of human JMJD5 jmj-c domain

Browse structure collections

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