6KUW: Alpha-2C adrenergic receptor

Crystal structure of human alpha2C adrenergic G protein-coupled receptor. Determined by X-ray diffraction at 2.8 Å resolution. Released 4 Dec 2019.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Homo sapiens
Chains
2
Atoms
7,627
Mol. weight
115.58 kDa
Ligands
OLA, OLC, CLR, E33
Released
4 Dec 2019

Explore 6KUW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6KUW contains 56 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix42-443
α-helix48-7831
α-helix80-823
α-helix85-873
α-helix88-10316
α-helix105-11410
α-helix120-15435
α-helix156-1605
α-helix165-18319
β-strand18911
β-strand20411
α-helix208-2158
α-helix216-2205
α-helix221-23919
α-helix241-10023
α-helix1016-102712
β-strand1033-103752
α-helix1048-105912
α-helix1062-10643
β-strand1067-107262
α-helix1077-108913
β-strand1093-109642
α-helix1102-11098
β-strand1114-111742
α-helix1126-11349
β-strand1137-114152
α-helix1145-11495
β-strand1156-115832
α-helix11591
α-helix1163-117715
α-helix1182-40852
α-helix409-4124
α-helix413-4153
α-helix416-42813
α-helix429-4313
α-helix433-4408
α-helix442-45211
Chain B: 27 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix48-7629
α-helix85-873
α-helix88-9912
α-helix100-1045
α-helix105-11410
α-helix120-15435
α-helix158-1614
α-helix165-18319
α-helix203-2053
α-helix208-2158
α-helix216-2205
α-helix221-23717
α-helix1009-10113
α-helix1016-102611
α-helix1029-10313
β-strand1034-103743
β-strand104114
α-helix1048-105811
β-strand1068-107253
β-strand107514
α-helix1077-108913
β-strand1093-109643
α-helix1099-11013
α-helix1102-11098
β-strand1114-111743
α-helix1126-11338
α-helix11361
β-strand1137-114153
α-helix1146-11494
β-strand1156-115833
α-helix1163-117715
α-helix1182-40852
α-helix409-4113
α-helix416-44025
α-helix442-45211

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Alpha-2C adrenergic receptorA, Bprotein496Homo sapiensP18825 (AlphaFold model), Q9V2J8 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>6KUW_1 Alpha-2C adrenergic receptor (chains A, B)
GGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNL
FLVSLASADILVATLVMPFSLANELMAYWYFGQWWCGVYLALDVLFCTSSAVHLCAISLD
RYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDET
WYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTGIDCSFWNESYLTGSRDERKKSLLSKF
GMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLE
EKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLR
DIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSVAQAREKRFTF
VLAVVMGVWVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQ
DFRRSFKHILFRRRRR

Ligands and cofactors

IDNameFormulaCopies
OLAOleic acidC18 H34 O22
OLC(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoateC21 H40 O47
CLRCholesterolC27 H46 O2
E33(8~{a}~{R},12~{a}~{S},13~{a}~{R})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,1…C19 H28 N2 O3 S2

Primary citation

Crystal structure of human alpha2C adrenergic G protein-coupled receptor. Chen, X.Y., Wu, D., Wu, L.J. et al. To be published.

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