6L6C: Human galectin-10

X-ray structure of human galectin-10 in complex with D-arabinose. Determined by X-ray diffraction at 1.77 Å resolution. Released 4 Mar 2020.

Method: X-ray diffraction
Resolution: 1.77 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,219
Mol. weight: 16.94 kDa
Ligands: 64K
Released: 4 Mar 2020

Explore 6L6C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6L6C contains 3 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	2-5	4
β-strand	8-11	4	1
β-strand	18-26	9	2
α-helix	30-32	3
β-strand	35-41	7	1
β-strand	50-57	8	1
β-strand	61-68	8	1
β-strand	71-72	2	1
β-strand	76-78	3	1
β-strand	89-95	7	2
β-strand	99-104	6	2
β-strand	107-113	7	2
α-helix	118-120	3
β-strand	123-128	6	1
β-strand	130-139	10	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Galectin-10	A	protein	144	Homo sapiens	Q05315 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6L6C_1 Galectin-10 (chains A)
GSMSLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIVFHFQVCF
GRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKP
EAVKMVQVWRDISLTKFNVSYLKR

Ligands and cofactors

ID	Name	Formula	Copies
64K	alpha-D-arabinopyranose	C5 H10 O5	2

Primary citation

Structures of human galectin-10/monosaccharide complexes demonstrate potential of monosaccharides as effectors in forming Charcot-Leyden crystals. Itoh, A., Nonaka, Y., Nakakita, S.I. et al. Biochem Biophys Res Commun (2020). DOI 10.1016/j.bbrc.2020.02.037 · PubMed

Other PDB entries of the same protein (UniProt Q05315 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6GKS 1.38 Å, X-ray structure determined from recombinant Charcot-Leyden crystal
6QRN 1.4 Å, Galectin-10 complexed with ribose
5XRG 1.55 Å, Galectin-10/Charcot-Leyden crystal protein crystal structure
5XRH 1.55 Å, Galectin-10/Charcot-Leyden crystal protein crystal structure
9UWN 1.57 Å, Crystal structure of E33A mutant of human galectin-10 produced by cell-free protein…
9UWP 1.57 Å, Crystal structure of human galectin-10 produced by cell-free protein synthesis in…
5XRN 1.6 Å, Galectin-10/Charcot-Leyden crystal protein variant K73A crystal structure
5XRO 1.6 Å, Galectin-10/Charcot-Leyden crystal protein variant Q74A crystal structure
9UWK 1.6 Å, Crystal structure of human galectin-10 produced by cell-free protein synthesis
6A1U 1.62 Å, Charcot-Leyden crystal protein/Galectin-10 variant E33D
8JAE 1.62 Å, Crystal structure of E33A mutant human galectin-10 produced by cell-free protein…
6A1S 1.63 Å, Charcot-Leyden crystal protein/Galectin-10 variant E33A

Browse structure collections

About this viewer

MolViewer shows 6L6C directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.