6MBA: Human Nav1.4 CTerminal Domain

Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin. Determined by X-ray diffraction at 1.8 Å resolution. Released 10 Apr 2019.

Method: X-ray diffraction
Resolution: 1.8 Å
Organisms: Homo sapiens, Rattus norvegicus
Chains: 2
Atoms: 2,358
Mol. weight: 36.85 kDa
Ligands: CO3
Released: 10 Apr 2019

Explore 6MBA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6MBA contains 19 α-helices and 9 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	1614-1627	14
β-strand	1634-1636	3	1
α-helix	1637-1639	3
α-helix	1640-1646	7
α-helix	1648	1
α-helix	1654	1
α-helix	1658-1663	6
β-strand	1667-1668	2	2
β-strand	1669	1	1
β-strand	1673-1675	3	1
α-helix	1676-1688	13
α-helix	1692-1705	14
β-strand	1719-1720	2	2
α-helix	1721-1745	25

Chain B: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-28	3	3
α-helix	29-38	10
α-helix	45-53	9
β-strand	62-64	3	3
α-helix	65-77	13
α-helix	79-81	3
α-helix	82-90	9
β-strand	99-101	3	4
α-helix	102-111	10
α-helix	115-117	3
α-helix	118-128	11
β-strand	135-137	3	4
α-helix	138-145	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sodium channel protein type 4 subunit alpha	A	protein	171	Homo sapiens	P35499 (AlphaFold model)
Calmodulin-1	B	protein	149	Rattus norvegicus	P0DP29 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6MBA_1 Sodium channel protein type 4 subunit alpha (chains A)
GPLGSENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRI
AKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKV
SYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD

Sequence of entity 2 (B), FASTA

>6MBA_2 Calmodulin-1 (chains B)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Ligands and cofactors

ID	Name	Formula	Copies
CO3	Carbonate ion	C O3	1

Water and common crystallization additives (TRS, EDO, CL) are not listed.

Primary citation

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Yoder, J.B., Ben-Johny, M., Farinelli, F. et al. Nat Commun (2019) 10:1514-1514. DOI 10.1038/s41467-019-09570-7 · PubMed

Other PDB entries of the same protein (UniProt P35499 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6AGF 3.2 Å, Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
6MC9 3.3 Å, Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with…

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