Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin. Determined by X-ray diffraction at 1.8 Å resolution. Released 10 Apr 2019.
Explore 6MBA in 3D Show helices and sheets RCSB PDB PDBe
6MBA contains 19 α-helices and 9 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1614-1627 | 14 | |
| β-strand | 1634-1636 | 3 | 1 |
| α-helix | 1637-1639 | 3 | |
| α-helix | 1640-1646 | 7 | |
| α-helix | 1648 | 1 | |
| α-helix | 1654 | 1 | |
| α-helix | 1658-1663 | 6 | |
| β-strand | 1667-1668 | 2 | 2 |
| β-strand | 1669 | 1 | 1 |
| β-strand | 1673-1675 | 3 | 1 |
| α-helix | 1676-1688 | 13 | |
| α-helix | 1692-1705 | 14 | |
| β-strand | 1719-1720 | 2 | 2 |
| α-helix | 1721-1745 | 25 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-19 | 14 | |
| β-strand | 26-28 | 3 | 3 |
| α-helix | 29-38 | 10 | |
| α-helix | 45-53 | 9 | |
| β-strand | 62-64 | 3 | 3 |
| α-helix | 65-77 | 13 | |
| α-helix | 79-81 | 3 | |
| α-helix | 82-90 | 9 | |
| β-strand | 99-101 | 3 | 4 |
| α-helix | 102-111 | 10 | |
| α-helix | 115-117 | 3 | |
| α-helix | 118-128 | 11 | |
| β-strand | 135-137 | 3 | 4 |
| α-helix | 138-145 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | A | protein | 171 | Homo sapiens | P35499 (AlphaFold model) |
| Calmodulin-1 | B | protein | 149 | Rattus norvegicus | P0DP29 (AlphaFold model) |
>6MBA_1 Sodium channel protein type 4 subunit alpha (chains A) GPLGSENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRI AKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKV SYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD
>6MBA_2 Calmodulin-1 (chains B) MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
| ID | Name | Formula | Copies |
|---|---|---|---|
| CO3 | Carbonate ion | C O3 | 1 |
Water and common crystallization additives (TRS, EDO, CL) are not listed.
Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Yoder, J.B., Ben-Johny, M., Farinelli, F. et al. Nat Commun (2019) 10:1514-1514. DOI 10.1038/s41467-019-09570-7 · PubMed
Other PDB entries of the same protein (UniProt P35499 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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