6O7U: Saccharomyces cerevisiae V-ATPase Stv1-VO

Saccharomyces cerevisiae V-ATPase Stv1-VO. Determined by electron microscopy at 3.1 Å resolution. Released 3 Apr 2019.

Method
Electron microscopy
Resolution
3.1 Å
Organism
Saccharomyces cerevisiae
Chains
15
Atoms
21,268
Mol. weight
362.27 kDa
Released
3 Apr 2019

Explore 6O7U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6O7U contains 123 α-helices and 16 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 37 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand1311
β-strand16-2162
α-helix25-3511
β-strand39-4022
α-helix58-7720
α-helix113-1175
α-helix119-16345
β-strand241-24553
α-helix246-2483
α-helix249-25911
β-strand267-27043
β-strand284-28853
α-helix297-3048
β-strand310-31123
α-helix321-35131
α-helix354-37118
β-strand380-38672
β-strand38811
α-helix389-3913
α-helix392-40514
β-strand415-41622
α-helix422-4243
β-strand42514
α-helix434-44310
α-helix450-4523
α-helix457-46812
α-helix472-48716
α-helix489-4935
α-helix499-5068
α-helix508-52417
β-strand540-54125
β-strand552-55326
β-strand555-55625
α-helix566-5683
α-helix574-59724
α-helix599-6079
α-helix611-6133
α-helix614-6185
α-helix619-6257
α-helix629-64113
α-helix650-6534
α-helix655-6639
α-helix676-68813
α-helix690-70213
α-helix704-7063
α-helix768-79023
α-helix795-81420
α-helix827-84317
α-helix844-8518
α-helix853-86513
β-strand87914
α-helix885-8873
Chain b: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix223-24523
α-helix251-2533
Chain c: 12 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix18-3821
α-helix42-443
α-helix47-537
α-helix56-8934
α-helix94-963
α-helix99-1013
α-helix102-12221
α-helix127-1293
α-helix136-17641
α-helix178-1803
α-helix181-19111
α-helix193-20513
Chain d: 18 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix6-83
α-helix11-2111
α-helix27-348
α-helix39-468
α-helix65-8521
α-helix90-11021
α-helix137-1404
α-helix146-1483
α-helix149-1535
α-helix159-1613
α-helix174-19926
α-helix203-22624
α-helix235-2384
α-helix249-2535
α-helix254-2574
α-helix262-2665
α-helix284-29714
α-helix307-32923
Chain e: 2 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix5-2218
α-helix30-5324
β-strand63-6426
Chain f: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix13-3220
α-helix48-7023
Chain g: 5 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix10-4233
α-helix47-493
α-helix55-7521
α-helix84-12138
α-helix125-15228
Chain h: 5 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix9-4234
α-helix47-493
α-helix55-7521
α-helix84-11633
α-helix125-15430

7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
V-type proton ATPase subunit a, Golgi isoformaprotein912Saccharomyces cerevisiaeP37296 (AlphaFold model)
V0 assembly protein 1bprotein265Saccharomyces cerevisiaeP53262 (AlphaFold model)
V-type proton ATPase subunit c''cprotein213Saccharomyces cerevisiaeP23968 (AlphaFold model)
V-type proton ATPase subunit ddprotein345Saccharomyces cerevisiaeP32366 (AlphaFold model)
V-type proton ATPase subunit eeprotein73Saccharomyces cerevisiaeQ3E7B6
Putative protein YPR170W-Bfprotein85Saccharomyces cerevisiaeP0C5R9
V-type proton ATPase subunit cg, h, i, j, k, l, m, nprotein160Saccharomyces cerevisiaeP25515
V-type proton ATPase subunit c'oprotein164Saccharomyces cerevisiaeP32842
Sequence of entity 1 (a), FASTA
>6O7U_1 V-type proton ATPase subunit a, Golgi isoform (chains a)
MNQEEAIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRR
FDEVERMVGFLNEVVEKHAAETWKYILHIDDEGNDIAQPDMADLINTMEPLSLENVNDMV
KEITDCESRARQLDESLDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEE
RDVDEFRMTPDDISETLSDAFSFDDETPQDRGALGNDLTRNQSVEDLSFLEQGYQHRYMI
TGSIRRTKVDILNRILWRLLRGNLIFQNFPIEEPLLEGKEKVEKDCFIIFTHGETLLKKV
KRVIDSLNGKIVSLNTRSSELVDTLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAM
TKREKYVYTTLNKFQQESQGLIAEGWVPSTELIHLQDSLKDYIETLGSEYSTVFNVILTN
KLPPTYHRTNKFTQAFQSIVDAYGIATYKEINAGLATVVTFPFMFAIMFGDMGHGFILFL
MALFLVLNERKFGAMHRDEIFDMAFTGRYVLLLMGAFSVYTGLLYNDIFSKSMTIFKSGW
QWPSTFRKGESIEAKKTGVYPFGLDFAWHGTDNGLLFSNSYKMKLSILMGYAHMTYSFMF
SYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLSWAIVYKWSKDWIKDDKPAPGLLNMLIN
MFLAPGTIDDQLYSGQAKLQVVLLLAALVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSV
GNIEHEEQIAQQRHSAEGFQGMIISDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTI
EFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMW
FVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIEDYKDHDGDYK
DHDIDYKDDDDK
Sequence of entity 2 (b), FASTA
>6O7U_2 V0 assembly protein 1 (chains b)
MVFGQLYALFIFTLSCCISKTVQADSSKESSSFISFDKESNWDTISTISSTADVISSVDS
AIAVFEFDNFSLLDNLMIDEEYPFFNRFFANDVSLTVHDDSPLNISQSLSPIMEQFTVDE
LPESASDLLYEYSLDDKSIVLFKFTSDAYDLKKLDEFIDSCLSFLEDKSGDNLTVVINSL
GWAFEDEDGDDEYATEETLSHHDNNKGKEGDDDILSSIWTEGLLMCLIVSALLLFILIVA
LSWISNLDITYGALEKSTNPIKKNN
Sequence of entity 3 (c), FASTA
>6O7U_3 V-type proton ATPase subunit c'' (chains c)
MNKESKDDDMSLGKFSFSHFLYYLVLIVVIVYGLYKLFTGHGSDINFGKFLLRTSPYMWA
NLGIALCVGLSVVGAAWGIFITGSSMIGAGVRAPRITTKNLISIIFCEVVAIYGLIIAIV
FSSKLTVATAENMYSKSNLYTGYSLFWAGITVGASNLICGIAVGITGATAAISDAADSAL
FVKILVIEIFGSILGLLGLIVGLLMAGKASEFQ
Sequence of entity 4 (d), FASTA
>6O7U_4 V-type proton ATPase subunit d (chains d)
MEGVYFNIDNGFIEGVVRGYRNGLLSNNQYINLTQCDTLEDLKLQLSSTDYGNFLSSVSS
ESLTTSLIQEYASSKLYHEFNYIRDQSSGSTRKFMDYITYGYMIDNVALMITGTIHDRDK
GEILQRCHPLGWFDTLPTLSVATDLESLYETVLVDTPLAPYFKNCFDTAEELDDMNIEII
RNKLYKAYLEDFYNFVTEEIPEPAKECMQTLLGFEADRRSINIALNSLQSSDIDPDLKSD
LLPNIGKLYPLATFHLAQAQDFEGVRAALANVYEYRGFLETGNLEDHFYQLEMELCRDAF
TQQFAISTVWAWMKSKEQEVRNITWIAECIAQNQRERINNYISVY
Sequence of entity 5 (e), FASTA
>6O7U_5 V-type proton ATPase subunit e (chains e)
MSSFYTVVGVFIVVSAMSVLFWIMAPKNNQAVWRSTVILTLAMMFLMWAITFLCQLHPLV
APRRSDLRPEFAE
Sequence of entity 6 (f), FASTA
>6O7U_6 Putative protein YPR170W-B (chains f)
MRPVVSTGKAWCCTVLSAFGVVILSVIAHLFNTNHESFVGSINDPEDGPAVAHTVYLAAL
VYLVFFVFCGFQVYLARRKPSIELR
Sequence of entity 7 (g, h, i, j, k, l, m, n), FASTA
>6O7U_7 V-type proton ATPase subunit c (chains g, h, i, j, k, l, m, n)
MTELCPVYAPFFGAIGCASAIIFTSLGAAYGTAKSGVGICATCVLRPDLLFKNIVPVIMA
GIIAIYGLVVSVLVCYSLGQKQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGSS
QQPRLFVGMILILIFAEVLGLYGLIVALLLNSRATQDVVC
Sequence of entity 8 (o), FASTA
>6O7U_8 V-type proton ATPase subunit c' (chains o)
MSTQLASNIYAPLYAPFFGFAGCAAAMVLSCLGAAIGTAKSGIGIAGIGTFKPELIMKSL
IPVVMSGILAIYGLVVAVLIAGNLSPTEDYTLFNGFMHLSCGLCVGFACLSSGYAIGMVG
DVGVRKYMHQPRLFVGIVLILIFSEVLGLYGMIVALILNTRGSE

Primary citation

Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Vasanthakumar, T., Bueler, S.A., Wu, D. et al. Proc Natl Acad Sci U S A (2019) 116:7272-7277. DOI 10.1073/pnas.1814818116 · PubMed

Other PDB entries of the same protein (UniProt P37296 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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