Structure of human Patched1. Determined by electron microscopy at 3.5 Å resolution. Released 10 Apr 2019.
Explore 6OEU in 3D Show helices and sheets RCSB PDB PDBe
6OEU contains 42 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 78-93 | 16 | |
| α-helix | 102-115 | 14 | |
| α-helix | 135-145 | 11 | |
| β-strand | 153-154 | 2 | 1 |
| β-strand | 157-161 | 5 | 2 |
| α-helix | 172-186 | 15 | |
| β-strand | 203 | 1 | 1 |
| α-helix | 216-221 | 6 | |
| α-helix | 231-234 | 4 | |
| β-strand | 246 | 1 | 3 |
| β-strand | 254 | 1 | 3 |
| α-helix | 262-270 | 9 | |
| α-helix | 276-282 | 7 | |
| β-strand | 328 | 1 | 4 |
| β-strand | 336 | 1 | 4 |
| α-helix | 339-342 | 4 | |
| β-strand | 343-344 | 2 | 2 |
| β-strand | 347 | 1 | 5 |
| β-strand | 354 | 1 | 5 |
| β-strand | 359-362 | 4 | 2 |
| β-strand | 366-367 | 2 | 1 |
| α-helix | 368 | 1 | |
| α-helix | 369-375 | 7 | |
| α-helix | 389-408 | 20 | |
| β-strand | 418-422 | 5 | 2 |
| α-helix | 425-435 | 11 | |
| α-helix | 437-438 | 2 | |
| α-helix | 439-455 | 17 | |
| α-helix | 470-490 | 21 | |
| α-helix | 493-495 | 3 | |
| α-helix | 503-524 | 22 | |
| α-helix | 536-560 | 25 | |
| α-helix | 568-601 | 34 | |
| α-helix | 733-740 | 8 | |
| α-helix | 747-769 | 23 | |
| α-helix | 777-779 | 3 | |
| α-helix | 786-797 | 12 | |
| β-strand | 800-801 | 2 | 6 |
| β-strand | 804-807 | 4 | 7 |
| α-helix | 817-824 | 8 | |
| β-strand | 832 | 1 | 6 |
| β-strand | 835 | 1 | 8 |
| β-strand | 839 | 1 | 8 |
| α-helix | 840-842 | 3 | |
| α-helix | 844-865 | 22 | |
| α-helix | 878-886 | 9 | |
| α-helix | 919-929 | 11 | |
| α-helix | 931-937 | 7 | |
| α-helix | 944-946 | 3 | |
| α-helix | 967-969 | 3 | |
| β-strand | 972-975 | 4 | 7 |
| β-strand | 978-979 | 2 | 6 |
| α-helix | 986-1003 | 18 | |
| β-strand | 1008-1011 | 4 | 7 |
| α-helix | 1014-1017 | 4 | |
| α-helix | 1024-1047 | 24 | |
| α-helix | 1050-1074 | 25 | |
| α-helix | 1080-1101 | 22 | |
| α-helix | 1103-1105 | 3 | |
| α-helix | 1113-1137 | 25 | |
| α-helix | 1138-1141 | 4 | |
| α-helix | 1148-1154 | 7 | |
| α-helix | 1155-1174 | 20 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein patched homolog 1 | A | protein | 1455 | Homo sapiens | Q13635 (AlphaFold model) |
>6OEU_1 Protein patched homolog 1 (chains A) MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAF ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK LQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPA DPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHAL QTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVL SFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALS VAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGEC LKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDL YRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQS TVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSL HCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDI VPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQL PKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDIS QLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETR LRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQ YIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSA VPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLML AGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEP PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATE NPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRR DAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVA VHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEER PRGSSSNDYKDDDDK
Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Qi, X., Schmiege, P., Coutavas, E. et al. Nature (2018) 560:128-132. DOI 10.1038/s41586-018-0308-7 · PubMed
Other PDB entries of the same protein (UniProt Q13635 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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