6Q83: Biportin Pdr6

Crystal structure of the biportin Pdr6 in complex with UBC9. Determined by X-ray diffraction at 4.53 Å resolution. Released 1 May 2019.

Method
X-ray diffraction
Resolution
4.53 Å
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains
2
Atoms
9,380
Mol. weight
141.35 kDa
Released
1 May 2019

Explore 6Q83 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6Q83 contains 71 α-helices and 13 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 63 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix4-1411
α-helix23-3311
α-helix39-4810
α-helix54-6512
α-helix80-9920
α-helix108-12518
α-helix145-1517
α-helix166-1727
α-helix177-1837
α-helix187-21024
α-helix217-2204
α-helix221-2255
α-helix226-23813
α-helix246-26116
α-helix273-28513
α-helix294-30916
α-helix311-3133
α-helix316-32611
α-helix345-35511
α-helix359-37315
α-helix378-3858
β-strand38611
α-helix397-41317
β-strand41812
β-strand42212
α-helix424-44017
α-helix444-4463
β-strand44711
α-helix451-46616
α-helix472-48110
α-helix486-51025
α-helix511-5155
α-helix516-5238
α-helix538-55619
α-helix565-5717
α-helix576-58813
α-helix595-61420
α-helix616-6216
α-helix623-6253
α-helix627-63913
α-helix650-67122
α-helix680-69011
α-helix699-71416
α-helix721-74525
α-helix750-76920
α-helix772-7732
α-helix787-7959
α-helix800-81213
α-helix815-8184
α-helix821-83111
α-helix837-8382
α-helix849-85911
α-helix865-88218
α-helix889-8957
α-helix896-9016
α-helix904-9085
α-helix912-92817
α-helix930-9345
α-helix939-9435
α-helix944-9496
α-helix956-97116
α-helix977-100428
α-helix1012-102312
α-helix1025-103814
α-helix1045-10473
α-helix1048-10558
α-helix1064-107512
Chain B: 8 helices, 9 β-strands
ElementResiduesLengthSheet
α-helix3-1816
β-strand25-3063
β-strand36-46113
α-helix47-482
β-strand5614
β-strand57-6373
α-helix72-732
β-strand74-7633
α-helix77-782
β-strand8615
β-strand9113
β-strand9215
α-helix95-973
α-helix109-12113
α-helix131-1399
α-helix141-15414
β-strand15614

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin beta-like protein KAP122Aprotein1080Saccharomyces cerevisiae (strain ATCC 204508 / S288c)P32767 (AlphaFold model)
UBC9Bprotein157Saccharomyces cerevisiae (strain ATCC 204508 / S288c)P50623 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6Q83_1 Importin beta-like protein KAP122 (chains A)
SSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGA
LTLTVQLNTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLI
FTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQNINADQLLLDSINCSLTYEQLSQ
FVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQA
VFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAEKILT
IFGNVFANDPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSE
LKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQ
EFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEE
EGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVL
FRIETMCFVLNTILVDMTLSESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILK
LDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMV
IKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGP
EEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDA
LLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGE
PYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFRKELTPQEFDFMFEKILL
VYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVA
VAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRSDLNSYTDLLRALV
AKFPIEAREWLVAVLPQICNNPAGHEKFINKLLITRGSRAAGNVILQWWLDCTTLPNYQG
Sequence of entity 2 (B), FASTA
>6Q83_2 UBC9 (chains B)
GSSLCLQRLQEERKKWRKDHPFGFYAKPVKKADGSMDLQKWEAGIPGKEGTNWAGGVYPI
TVEYPNEYPSKPPKVKFPAGFYHPNVYPSGTICLSILNEDQDWRPAITLKQIVLGVQDLL
DSPNPNSPAQEPAWRSFSRNKAEYDKKVLLQAKQYSK

Primary citation

Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. Aksu, M., Trakhanov, S., Vera Rodriguez, A. et al. J Cell Biol (2019) 218:1839-1852. DOI 10.1083/jcb.201812093 · PubMed

Other PDB entries of the same protein (UniProt P32767 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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