6TIK: PDB entry 6TIK

Hepatitis B virus core shell--virus-like particle with NadA epitope. Determined by electron microscopy at 3.4 Å resolution. Released 29 Apr 2020.

Method
Electron microscopy
Resolution
3.4 Å
Organisms
Hepatitis B virus, Neisseria meningitidis
Chains
4
Atoms
4,420
Mol. weight
248.47 kDa
Released
29 Apr 2020

Explore 6TIK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6TIK contains 46 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix7-93
α-helix21-233
α-helix25-262
α-helix27-4216
α-helix50-7526
α-helix387-3915
α-helix392-3965
α-helix397-41317
α-helix415-43016
α-helix440-4412
Chain B: 11 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-93
α-helix21-233
α-helix25-262
α-helix27-3711
α-helix39-424
α-helix50-7324
α-helix387-3915
α-helix392-3965
α-helix397-41317
α-helix415-43016
α-helix440-4423
Chain C: 13 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-93
α-helix13-175
α-helix21-233
α-helix25-262
α-helix27-3711
α-helix39-435
α-helix50-7526
α-helix387-3915
α-helix392-3965
α-helix397-41317
α-helix415-42915
α-helix433-4353
α-helix440-4412
Chain D: 12 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-93
α-helix15-173
α-helix25-262
α-helix27-3711
α-helix39-435
α-helix50-7526
α-helix387-3915
α-helix392-3965
α-helix397-41317
α-helix415-43016
α-helix433-4353
α-helix440-4412

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Capsid protein,Putative adhesin/invasin,Capsid protein,Factor H-binding proteinA, B, C, Dprotein589Hepatitis B virus, Neisseria meningitidisD3IRF1 (AlphaFold model), Q67855, Q6QCC2 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>6TIK_1 Capsid protein,Putative adhesin/invasin,Capsid protein,Factor H-binding protein (chains A, B, C, D)
MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAIL
CWGELMTLATWVGNNLEDGGGGSGGGGSATSDDDVKKAATVAIVAAYNNGQEINGFKAGE
TIYDIGEDGTITQKDATAADVEADDFKGLGLKKVVTNLTKTVNENKQNVDAKVKAAESEI
EKLTTKLADTDAALADTDAALDETTNALNKLGENITTFAEETKTNIVKIDEKLEAVADTV
DKHAEAFNDIADSLDETNTKADEAVKTANEAKQTAEETKQNVDAKVKAAETAAGKAEAAA
GTANTAADKAEAVAAKVTDIKADIATNKADIAKNSARIDSLDKNVANLRKETRQGLAEQA
ALSGLFQPYNVGEFGGGGSGGGGSRDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLE
YLVSFGVWIRTPPAYRPPNAPILSTLPETTVVGSGGGTHTSFDKLPEGGRATYRGTAFGS
DDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEK
GSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQKLGGGWSHPQFEK

Primary citation

An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis. Aston-Deaville, S., Carlsson, E., Saleem, M. et al. Vaccine (2020) 38:3201-3209. DOI 10.1016/j.vaccine.2020.03.001 · PubMed

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