6TOQ: PP2A B56y/HTLV-1 integrase complex

Crystal structure of a PP2A B56y/HTLV-1 integrase complex. Determined by X-ray diffraction at 3.16 Å resolution. Released 21 Oct 2020.

Method
X-ray diffraction
Resolution
3.16 Å
Organisms
Human T-cell leukemia virus type I, Homo sapiens
Chains
2
Atoms
2,720
Mol. weight
54.47 kDa
Released
21 Oct 2020

Explore 6TOQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6TOQ contains 26 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 26 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix40-489
α-helix63-8220
α-helix89-913
α-helix92-10312
α-helix131-14010
α-helix152-1554
α-helix161-1688
α-helix169-1724
α-helix176-19217
α-helix194-21219
α-helix221-23313
α-helix235-2362
α-helix239-2402
α-helix241-2466
α-helix247-2515
α-helix253-2564
α-helix260-2623
α-helix264-27714
α-helix279-2813
α-helix282-29110
α-helix301-31212
α-helix317-3204
α-helix324-33411
α-helix340-3478
α-helix348-3514
α-helix353-36614

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Pol proteinCCCprotein98Human T-cell leukemia virus type IA0A1Y1CAL3
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformAAAprotein370Homo sapiensQ13362 (AlphaFold model)
Sequence of entity 1 (CCC), FASTA
>6TOQ_1 Pol protein (chains CCC)
CHKTRWQLHHSPRLQPIPETHSLSNKQTHWYYFKLPGLNSRQWKGPQEALQEAAGAALIP
VSASSAQWIPWRLLKRAACPRPVGGPADPKEKDHQHHG
Sequence of entity 2 (AAA), FASTA
>6TOQ_2 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (chains AAA)
MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKR
AALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAA
WPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIY
GKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKV
LLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEE
ILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIM
FPSLYRNSKT

Primary citation

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56 gamma. Barski, M.S., Minnell, J.J., Hodakova, Z. et al. Nat Commun (2020) 11:5043-5043. DOI 10.1038/s41467-020-18874-y · PubMed

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