6UJQ: MHC class I antigen

HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206. Determined by X-ray diffraction at 2.55 Å resolution. Released 19 Aug 2020.

Method: X-ray diffraction
Resolution: 2.55 Å
Organism: Homo sapiens
Chains: 3
Atoms: 3,247
Mol. weight: 45.08 kDa
Released: 19 Aug 2020

Explore 6UJQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6UJQ contains 12 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-224	3	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chain B: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	276	Homo sapiens	U5YJP1 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
Protein-cysteine N-palmitoyltransferase HHAT	C	protein	9	Homo sapiens	Q5VTY9 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6UJQ_1 MHC class I antigen (chains A)
MGSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEY
WDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYD
GKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETL
QRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDG
TFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (B), FASTA

>6UJQ_2 Beta-2-microglobulin (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>6UJQ_3 Protein-cysteine N-palmitoyltransferase HHAT (chains C)
KQWLVWLLL

Primary citation

Structural dissimilarity from self drives neoepitope escape from immune tolerance. Devlin, J.R., Alonso, J.A., Ayres, C.M. et al. Nat Chem Biol (2020) 16:1269-1276. DOI 10.1038/s41589-020-0610-1 · PubMed

Other PDB entries of the same protein (UniProt U5YJP1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6UJO 2.25 Å, HHAT L75F Neoantigen Peptide KQWLVWLFL Presented by HLA-A206
6UK4 2.7 Å, Complex of T cell Receptor with HHAT Neoantigen Peptide KQWLVWLFL Presented by HLA-A206
6UK2 3.14 Å, Complex of T cell Receptor with HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206

Browse structure collections

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