6UXV: SWI/SNF Body Module
SWI/SNF Body Module. Determined by electron microscopy at 4.7 Å resolution. Released 18 Mar 2020.
- Method
- Electron microscopy
- Resolution
- 4.7 Å
- Organisms
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae S288C
- Chains
- 15
- Atoms
- 16,649
- Mol. weight
- 921.55 kDa
- Released
- 18 Mar 2020
Explore 6UXV in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6UXV contains 94 α-helices and 20 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 491-517 | 27 | |
| α-helix | 526-556 | 31 | |
| α-helix | 576-596 | 21 | |
Chain B: 24 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 706 | 1 | 1 |
| α-helix | 710-714 | 5 | |
| α-helix | 718-733 | 16 | |
| α-helix | 747-764 | 18 | |
| β-strand | 780 | 1 | 2 |
| α-helix | 793-804 | 12 | |
| α-helix | 866-867 | 2 | |
| α-helix | 886-894 | 9 | |
| α-helix | 910-928 | 19 | |
| α-helix | 934-937 | 4 | |
| α-helix | 942-956 | 15 | |
| α-helix | 965-980 | 16 | |
| α-helix | 990-1002 | 13 | |
| β-strand | 1006-1007 | 2 | 3 |
| β-strand | 1025-1026 | 2 | 3 |
| α-helix | 1027-1028 | 2 | |
| α-helix | 1035-1045 | 11 | |
| α-helix | 1054-1060 | 7 | |
| α-helix | 1080-1089 | 10 | |
| α-helix | 1090-1092 | 3 | |
| α-helix | 1106-1113 | 8 | |
| α-helix | 1128-1136 | 9 | |
| α-helix | 1138-1148 | 11 | |
| α-helix | 1204-1215 | 12 | |
| α-helix | 1233-1258 | 26 | |
| α-helix | 1264-1269 | 6 | |
| α-helix | 1279-1285 | 7 | |
| α-helix | 1293-1313 | 21 | |
Chain C: 7 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 427 | 1 | 1 |
| α-helix | 443-449 | 7 | |
| β-strand | 458-461 | 4 | 4 |
| β-strand | 467 | 1 | 5 |
| β-strand | 469 | 1 | 5 |
| β-strand | 476-479 | 4 | 4 |
| α-helix | 488-498 | 11 | |
| α-helix | 511-521 | 11 | |
| α-helix | 529-532 | 4 | |
| β-strand | 543-552 | 10 | 6 |
| β-strand | 555-564 | 10 | 6 |
| α-helix | 572-579 | 8 | |
| α-helix | 588-609 | 22 | |
| α-helix | 646-648 | 3 | |
| β-strand | 654-655 | 2 | 6 |
Chain D: 9 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 309-311 | 3 | |
| α-helix | 321-326 | 6 | |
| α-helix | 328-331 | 4 | |
| α-helix | 340-356 | 17 | |
| α-helix | 365-371 | 7 | |
| α-helix | 375-387 | 13 | |
| β-strand | 411-412 | 2 | 7 |
| α-helix | 424-426 | 3 | |
| α-helix | 437-441 | 5 | |
| α-helix | 450-460 | 11 | |
Chain E: 7 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 306-307 | 2 | 7 |
| α-helix | 309-311 | 3 | |
| β-strand | 315 | 1 | 2 |
| β-strand | 318 | 1 | 2 |
| α-helix | 321-326 | 6 | |
| α-helix | 328-330 | 3 | |
| α-helix | 340-356 | 17 | |
| α-helix | 364-370 | 7 | |
| α-helix | 376-387 | 12 | |
| α-helix | 430-433 | 4 | |
Chain F: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 529-541 | 13 | |
| α-helix | 546-551 | 6 | |
| α-helix | 558-565 | 8 | |
| α-helix | 612-623 | 12 | |
| α-helix | 637-646 | 10 | |
| α-helix | 652-702 | 51 | |
| α-helix | 703-707 | 5 | |
| α-helix | 708-748 | 41 | |
| α-helix | 767-779 | 13 | |
Chain G: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 529-540 | 12 | |
| α-helix | 546-551 | 6 | |
| α-helix | 558-566 | 9 | |
| α-helix | 626-629 | 4 | |
| α-helix | 635-654 | 20 | |
| α-helix | 681-746 | 66 | |
| α-helix | 764-778 | 15 | |
Chain H: 12 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 83-113 | 31 | |
| α-helix | 114-116 | 3 | |
| α-helix | 312-317 | 6 | |
| α-helix | 325-339 | 15 | |
| β-strand | 342 | 1 | 8 |
| β-strand | 378-380 | 3 | 8 |
| α-helix | 383-386 | 4 | |
| α-helix | 394-396 | 3 | |
| β-strand | 400-402 | 3 | 8 |
| α-helix | 403-409 | 7 | |
| α-helix | 451-455 | 5 | |
| α-helix | 460-509 | 50 | |
| α-helix | 511-528 | 18 | |
| α-helix | 541-546 | 6 | |
| α-helix | 550-561 | 12 | |
7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription regulatory protein SNF2 | A | protein | 1703 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P22082 (AlphaFold model) |
| SWI/SNF chromatin-remodeling complex subunit SWI1 | B | protein | 1314 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P09547 (AlphaFold model) |
| SWI/SNF chromatin-remodeling complex subunit SNF5 | C | protein | 905 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P18480 (AlphaFold model) |
| SWI/SNF complex subunit SWI3 | D, E, F, G | protein | 825 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32591 (AlphaFold model) |
| Transcription regulatory protein SNF12 | H | protein | 566 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P53628 |
| Transcription regulatory protein SNF6 | I | protein | 179 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae S288C | P18888 |
| Unknown protein | J | protein | 67 | Saccharomyces cerevisiae S288C | |
| Unknown protein | K | protein | 28 | Saccharomyces cerevisiae S288C | |
| Unknown protein | L, O | protein | 18 | Saccharomyces cerevisiae S288C | |
| SWI/SNF global transcription activator complex subunit SWP82 | M | protein | 83 | Saccharomyces cerevisiae S288C | |
| Unknown protein | N | protein | 30 | Saccharomyces cerevisiae S288C | |
Sequence of entity 1 (A), FASTA
>6UXV_1 Transcription regulatory protein SNF2 (chains A)
MNIPQRQFSNEEVNRCYLRWQHLRNEHGMNAPSVPEFIYLTKVLQFAAKQRQELQMQRQQ
QGISGSQQNIVPNSSDQAELPNNASSHISASASPHLAPNMQLNGNETFSTSAHQSPIMQT
QMPLNSNGGNNMLPQRQSSVGSLNATNFSPTPANNGENAAEKPDNSNHNNLNLNNSELQP
QNRSLQEHNIQDSNVMPGSQINSPMPQQAQMQQAQFQAQQAQQAQQAQQAQQAQARLQQG
RRLPMTMFTAEQSELLKAQITSLKCLVNRKPIPFEFQAVIQKSINHPPDFKRMLLSLSEF
ARRRQPTDQNNQSNLNGGNNTQQPGTNSHYNNTNTDNVSGLTRNAPLDSKDENFASVSPA
GPSSVHNAKNGTLDKNSQTVSGTPITQTESKKEENETISNVAKTAPNSNKTHTEQNNPPK
PQKPVPLNVLQDQYKEGIKVVDIDDPDMMVDSFTMPNISHSNIDYQTLLANSDHAKFTIE
PGVLPVGIDTHTATDIYQTLIALNLDTTVNDCLDKLLNDECTESTRENALYDYYALQLLP
LQKAVRGHVLQFEWHQNSLLTNTHPNFLSKIRNINVQDALLTNQLYKNHELLKLERKKTE
AVARLKSMNKSAINQYNRRQDKKNKRLKFGHRLIATHTNLERDEQKRAEKKAKERLQALK
ANDEEAYIKLLDQTKDTRITHLLRQTNAFLDSLTRAVKDQQKYTKEMIDSHIKEASEEVD
DLSMVPKMKDEEYDDDDDNSNVDYYNVAHRIKEDIKKQPSILVGGTLKDYQIKGLQWMVS
LFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIRGPYLVIVPLSTLSNWSSEFAKWAP
TLRTISFKGSPNERKAKQAKIRAGEFDVVLTTFEYIIKERALLSKVKWVHMIIDEGHRMK
NAQSKLSLTLNTHYHADYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPF
ANTGGQDKIELSEEETLLVIRRLHKVLRPFLLRRLKKDVEKELPDKVEKVVKCKMSALQQ
IMYQQMLKYRRLFIGDQNNKKMVGLRGFNNQIMQLKKICNHPFVFEEVEDQINPTRETND
DIWRVAGKFELLDRILPKLKATGHRVLIFFQMTQIMDIMEDFLRYINIKYLRLDGHTKSD
ERSELLRLFNAPDSEYLCFILSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRI
GQKNEVRILRLITTNSVEEVILERAYKKLDIDGKVIQAGKFDNKSTSEEQEALLRSLLDA
EEERRKKRESGVEEEEELKDSEINEILARNDEEMAVLTRMDEDRSKKEEELGVKSRLLEK
SELPDIYSRDIGAELKREESESAAVYNGRGARERKTATYNDNMSEEQWLRQFEVSDDEKN
DKQARKQRTKKEDKSEAIDGNGEIKGENIDADNDGPRINNISAEDRADTDLAMNDDDFLS
KKRKAGRPRGRPKKVKLEGSENSEPPALESSPVTGDNSPSEDFMDIPKPRTAGKTSVKSA
RTSTRGRGRGRGRGRGRGRGRGRPPKARNGLDYVRTPAAATSPIDIREKVAKQALDLYHF
ALNYENEAGRKLSDIFLSKPSKALYPDYYMIIKYPVAFDNINTHIETLAYNSLKETLQDF
HLIFSNARIYNTEGSVVYEDSLELEKVVTKKYCEIMGDNSQLDFTEFDEQYGTRPLVLPP
VVTSSVAESFTDEADSSMTEASV
Sequence of entity 2 (B), FASTA
>6UXV_2 SWI/SNF chromatin-remodeling complex subunit SWI1 (chains B)
MDFFNLNNNNNNNNTTTTTTTTNNNNTNNNNTNNNNNPANNTNNNNSTGHSSNTNNNTNN
NNTNTGASGVDDFQNFFDPKPFDQNLDSNNNNSNSNNNDNNNSNTVASSTNFTSPTAVVN
NAAPANVTGGKAANFIQNQSPQFNSPYDSNNSNTNLNSLSPQAILAKNSIIDSSNLPLQA
QQQLYGGNNNNNSTGIANDNVITPHFITNVQSISQNSSSSTPNTNSNSTPNANQQFLPFN
NSASNNGNLTSNQLISNYAASNSMDRSSSASNEFVPNTSDNNNNSNNHNMRNNSNNKTSN
NNNVTAVPAATPANTNNSTSNANTVFSERAAMFAALQQKQQQRFQALQQQQQQQQNQQQQ
NQQPQQQQQQQQNPKFLQSQRQQQQRSILQSLNPALQEKISTELNNKQYELFMKSLIENC
KKRNMPLQSIPEIGNRKINLFYLYMLVQKFGGADQVTRTQQWSMVAQRLQISDYQQLESI
YFRILLPYERHMISQEGIKETQAKRIFLQQFLQELLKKVQQQQQAAALANANNNINSASS
APTPAAPGASVPATAAPGTEAGIVPVSANTPKSLNSNININVNNNNIGQQQVKKPRKQRV
KKKTKKELELERKEREDFQKRQQKLLEDQQRQQKLLLETKLRQQYEIELKKLPKVYKRSI
VRNYKPLINRLKHYNGYDINYISKIGEKIDSNKPIFLFAPELGAINLHALSMSLQSKNLG
EINTALNTLLVTSADSNLKISLVKYPELLDSLAILGMNLLSNLSQNVVPYHRNTSDYYYE
DAGSNQYYVTQHDKMVDKIFEKVNNNATLTPNDSNDEKVTILVDSLTGNQLPTPTPTEME
PDLDTECFISMQSTSPAVKQWDLLPEPIRFLPNQFPLKIHRTPYLTSLKKIKDEIDDPFT
KINTRGAEDPKVLINDQLSTISMILRNISFSDNNSRIMSRNFYLKRFISDLLWLVLIHPE
NFTCNRKILNFKKDLVIVLSNISHLLEIASSIDCLLILILVISFGQPKLNPMASSSSFGS
ESLTFNEFQLQWGKYQTFGVDILAKLFSLEKPNLNYFKSILLNKNTGNNLYDRNSNNNHK
DKKLLRRLLNLYNDNNKNNNNRHNLLNDVVSFLFSAIPLQQVLSQSADPSLLIDQFSPVI
SQSLTSILVIVQKILPLSNEVFEISENNSDSNSNNNGNKDSSFNFNKNLPFVWLSSEENI
GSGLLKLSEIILNINNSTSKNTLLQQQNYSKVLLPSINISCVQLIKCLVEKSICFENCLN
NDPEILKKIASIPNLFPTDLEIFQLFTNPSVDIQIINQYQLLYNLKNDILTNLE
Sequence of entity 3 (C), FASTA
>6UXV_3 SWI/SNF chromatin-remodeling complex subunit SNF5 (chains C)
MNNQPQGTNSVPNSIGNIFSNIGTPSFNMAQIPQQLYQSLTPQQLQMIQQRHQQLLRSRL
QQQQQQQQQTSPPPQTHQSPPPPPQQSQPIANQSATSTPPPPPAPHNLHPQIGQVPLAPA
PINLPPQIAQLPLATQQQVLNKLRQQAIAKNNPQVVNAITVAQQQVQRQIEQQKGQQTAQ
TQLEQQRQLLVQQQQQQQLRNQIQRQQQQQFRHHVQIQQQQQKQQQQQQQHQQQQQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQGQIPQSQQVPQVRSMSGQPPTNVQPTIGQLPQ
LPKLNLPKYQTIQYDPPETKLPYPTYWSDKKADTDTLLYEQIIQRDKINKYSLIRETNGY
DPFSIYGFSNKEYISRLWHTLKYYQDLKNTRMKSITSTSQKIPSASIWGNGYSGYGNGIT
NTTTRVIPQVEVGNRKHYLEDKLKVYKQAMNETSEQLVPIRLEFDQDRDRFFLRDTLLWN
KNDKLIKIEDFVDDMLRDYRFEDATREQHIDTICQSIQEQIQEFQGNPYIELNQDRLGGD
DLRIRIKLDIVVGQNQLIDQFEWDISNSDNCPEEFAESMCQELELPGEFVTAIAHSIREQ
VHMYHKSLALLGYNFDGSAIEDDDIRSRMLPTITLDDVYRPAAESKIFTPNLLQISAAEL
ERLDKDKDRDTRRKRRQGRSNRRGMLALSGTSASNTSMNGVHNTVAAGNASSLPPGEILL
PDIADIPRTFRTPVPSTLMPGGVDVGPSVESYELRNTTTYKSRPDRPKPVSPPCYIIDHI
PGHSLLLSIKLPGKVNTKEEFAAAPNDTSSGTNAMLPSPESLKTKLNSNIRAGVTIPSIP
NPIANHTVTNSPNPTLQPVIPGGAASKSVPTPSLPIAPPVAPHDSEATLLTNSNNGSSNN
NTQNT
Sequence of entity 4 (D, E, F, G), FASTA
>6UXV_4 SWI/SNF complex subunit SWI3 (chains D, E, F, G)
MENTLGEGSTVNASVDVDQHGNDNNSDSNANAAVAGVANTDTAGEESQQQDESLKDEATV
PNTRDAESEAITVTAKQQPTMQANKLDSQETPSTEESRAQNVFGQDNEDSDNLFGETESS
VSNNEANTPSIPTNPVDNENNKPAIKEDSTIQDSNGDVKNMEDVKIQKEEEPENNTVIEG
VKEESQPDENTKEMDEVEEDDEDDDQPMISPDNSIFGDTKSESKQLGNTSSVANTPSEIP
DAHKAEQEDIIEKTESVDKKVDSGEERNEQEREIMNDHSKSANPKKTTITRVEPETFEIP
QAHEIVIPSYSKWFNLEKIHSIEVQSLPEFFTNRIPSKTPEVYMRYRNFMVNSYRLNPNE
YFSVTTARRNVSGDAAALFRLHKFLTKWGLINYQVDSKLLPKNIEPPLTSQYSTRHDAPR
GLFPFESYKPSVQLPDMAKLKKMMNTSDSESTLYKYLKESKRKYDEITHPPSTTDDENGD
KNDNGGKMNNEVSTSTSMTGDANLLEEGETSRPLKKVKILEQIDENWSKEDLQKLLKGIQ
EFGADWYKVAKNVGNKSPEQCILRFLQLPIEDKFLYGDGNGKGDNDNGLGPLKYAPHLPF
SKSENPVLSTIAFLVGLVNPKTVQSMTQRAIQSAESIKSQKEEISDQKPIEHIKEGSEIA
ISSLGYRSHIFATNEERQMNFLTNELIRLQMEKLDAKLNHLKKLEKFMELERKTLERQQE
NLLIQRLNFNQNSSKIVNVLSKCLNLISDSNINNSSVAEKEEIRSQIDHFKSMLSKPETL
SIGKNPFNKPNIETGENHNGQSISNENDVKPISIEAPQFYRYWSA
Sequence of entity 5 (H), FASTA
>6UXV_5 Transcription regulatory protein SNF12 (chains H)
MSKVMKPSNGKGSRKSSKAATPDTKNFFHAKKKDPVNQDKANNASQITPTVPHSHPSDMV
IPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLHMKRMVAQWERSKLSQEFLYPHLNFP
NVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRIEGRLLDNVQANDPAREKFSS
FIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKKLNLNLPLQFSLPNGDNSTTTNT
DQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPVDFDGLDIKRVGSENVECTISILRK
SSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYKYIHLNELLTNDESAFENLMGNRNNHN
SNTSTSKMLDAASSQVSIVKLDTQLITLLPSSLKESSPDTMKLTDLLSLINSTHLLPLQP
IEIDYTVRVDKASTYGELVLDIEVPDVNALKFNNTQRESQIGAAELNENARELEQIKPKI
ALQDKEITSVLSNLHESNKRYRFFKKISEDPVKALNECIASTSNALKVLSGDEGYNEDMV
RRANFYKENEAMLRENIEVILSNGRM
Sequence of entity 6 (I), FASTA
>6UXV_6 Transcription regulatory protein SNF6 (chains I)
MGVIKKKRSHHGKASRQQYYSGVQVGGVGSMGAINNNIPSLTSFAEENNYQYGYSGSSAG
MNGRSLTYAQQQLNKQRQDFERVRLRPEQLSNIIHDESDTISFRSNLLKNFISSNDAFNM
LSLTTVPCDRIEKSRLFSEKTIRYLMQKQHXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 7 (J), FASTA
>6UXV_7 Unknown protein (chains J)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX
Sequence of entity 8 (K), FASTA
>6UXV_8 Unknown protein (chains K)
XXXXXXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 9 (L, O), FASTA
>6UXV_9 Unknown protein (chains L, O)
XXXXXXXXXXXXXXXXXX
Sequence of entity 10 (M), FASTA
>6UXV_10 SWI/SNF global transcription activator complex subunit SWP82 (chains M)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 11 (N), FASTA
>6UXV_11 Unknown protein (chains N)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Primary citation
Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Han, Y., Reyes, A.A., Malik, S. et al. Nature (2020) 579:452-455. DOI 10.1038/s41586-020-2087-1 · PubMed
Other PDB entries of the same protein (UniProt P22082 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7VRC 2.15 Å, Structure of the Yeast SNF11/SNF2 complex
- 4I6M 2.8 Å, Structure of Arp7-Arp9-Snf2(HSA)-RTT102 subcomplex of SWI/SNF chromatin remodeler.
- 7C4J 2.89 Å, Cryo-EM structure of the yeast Swi/Snf complex in a nucleosome free state
- 6IY2 3.47 Å, Structure of Snf2-MMTV-A nucleosome complex at shl2 in ADP state
- 7EGM 3.6 Å, The SRM module of SWI/SNF-nucleosome complex
- 5Z3O 3.62 Å, Structure of Snf2-nucleosome complex in ADP state
- 6IY3 3.67 Å, Structure of Snf2-MMTV-A nucleosome complex at shl-2 in ADP state
- 5X0X 3.97 Å, Complex of Snf2-Nucleosome complex with Snf2 bound to position +6 of the nucleosome
- 9PB3 4.0 Å, ARP of SWI/SNF of PIC-Med-SWI/SNF
- 5Z3V 4.22 Å, Structure of Snf2-nucleosome complex at shl-2 in ADP BeFx state
- 5Z3L 4.31 Å, Structure of Snf2-nucleosome complex in apo state
- 5Z3U 4.31 Å, Structure of Snf2-nucleosome complex at shl2 in ADP BeFx state
Browse structure collections
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