6V8O: RSC core
RSC core. Determined by electron microscopy at 3.07 Å resolution. Released 15 Jan 2020.
- Method
- Electron microscopy
- Resolution
- 3.07 Å
- Organism
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
- Chains
- 22
- Atoms
- 25,103
- Mol. weight
- 1105.46 kDa
- Ligands
- ZN
- Released
- 15 Jan 2020
Explore 6V8O in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6V8O contains 155 α-helices and 85 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 348 | 1 | 4 |
Chain 3: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-19 | 17 | |
Chain 4: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1-17 | 17 | |
Chain 5: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-15 | 12 | |
Chain 6: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 421-433 | 13 | |
Chain 7: 0 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 24-31 | 8 | 18 |
| β-strand | 37-40 | 4 | 18 |
| β-strand | 52-56 | 5 | 19 |
| β-strand | 61-65 | 5 | 19 |
Chain C: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-39 | 19 | |
| α-helix | 46-53 | 8 | |
| α-helix | 55-74 | 20 | |
Chain D: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-17 | 10 | |
| α-helix | 28-34 | 7 | |
| α-helix | 69-72 | 4 | |
| α-helix | 73-78 | 6 | |
| α-helix | 80-81 | 2 | |
| α-helix | 94-98 | 5 | |
| α-helix | 102-109 | 8 | |
| α-helix | 110-114 | 5 | |
| α-helix | 116-124 | 9 | |
14 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| High temperature lethal protein 1 | C | protein | 78 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q9URQ5 (AlphaFold model) |
| Chromatin structure-remodeling complex protein RSC14 | D | protein | 180 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P38210 (AlphaFold model) |
| Chromatin structure-remodeling complex subunit RSC7 | E | protein | 435 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32832 (AlphaFold model) |
| Chromatin structure-remodeling complex subunit RSC2 | F | protein | 889 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q06488 (AlphaFold model) |
| Chromatin structure-remodeling complex protein RSC3 | G | protein | 885 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q06639 |
| Chromatin structure-remodeling complex subunit RSC4 | H | protein | 625 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q02206 |
| Chromatin structure-remodeling complex protein RSC8 | I, J, K, L | protein | 557 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P43609 |
| Chromatin structure-remodeling complex protein RSC6 | M | protein | 483 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P25632 |
| Chromatin structure-remodeling complex subunit RSC9 | N | protein | 581 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q03124 |
| Chromatin structure-remodeling complex protein RSC58 | O | protein | 502 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q07979 |
| Chromatin structure-remodeling complex subunit SFH1 | Q | protein | 426 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q06168 |
| Nuclear protein STH1/NPS1 | R | protein | 1359 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32597 |
6 more molecules are not listed.
Sequence of entity 1 (C), FASTA
>6V8O_1 High temperature lethal protein 1 (chains C)
MSQNNTISSMNPERAYNNVTLKNLTAFQLLSQRENICELLNLVESTERHNSIINPERQRM
SLEEMKKMLDALKNERKK
Sequence of entity 2 (D), FASTA
>6V8O_2 Chromatin structure-remodeling complex protein RSC14 (chains D)
MSGSNMGYYDVLAGLSALEKSSQVVFSATELQQLTQQSHATDKGIEGSENSKAKVSKPKR
VAVHGYLGGKVSLADAAQVEYEVGHSLLGSYVPRQQLEALSSVDFSHHFHRTLECKAALE
THDVFLAGAGQLSLPFQSHIESPRNSEAKRKRKVIICKRCQSRFIGSHRRSQLREHACVD
Sequence of entity 3 (E), FASTA
>6V8O_3 Chromatin structure-remodeling complex subunit RSC7 (chains E)
MSDSEGGLASEVEHEKRSRSTSNRPNYAIDTEDLDIDENDENEDDDYREEEANEGVNEEE
ISDEEEQINKSGRNKRRHVDEEEDLSEDKGVTRSRNRSKFKKPVFPGIDDAEENLNPLKV
VNEEYVLPDDPEGETKITADGDLLGGREFLVRTFTLTEKGNRKFMLATEPARIVGFRDSY
LFFQTHPNLYKFILNQTQKNDLIDRGVLPYSYRNRQIALVTARGVFKEFGAKIIRGGKHI
TDDYYASELRTKGNVIEGKLAGDPIDKSARALETMMYPASENGINPAKNQVEFFEHRPHG
HMSNSNIIASGSKLSSTNWLYQHSAACSRFNSDLFYDRVKVLLVDQQGLRDAYTNILHIP
ESTQSTTVLGWRRSKNDSPSDTSIVYETVIHDNDLNKPKTGLSEIPKEIYEDVVDEDVLR
AITEQQNFEKCNEYI
Sequence of entity 4 (F), FASTA
>6V8O_4 Chromatin structure-remodeling complex subunit RSC2 (chains F)
MMPDDNSNSSTQNSSALYKDLRKEYESLFTLKEDSGLEISPIFNVLPPKKDYPDYYAVIK
NPVSFNTLKKRIPHYTDAQQFMNDVVQIPWNAKTYNTRDSGIYKYALVLEKYLKDTIYPN
LKEKYPQLVYPDLGPLPDEPGYEEFQQKLREKAEEVARANAARAESSSSMNSTEAARRLR
KTRTSVKRESEPGTDTNNDEDYEATDMDIDNPKDADFPDLIRKPLININPYTRKPLRDNR
STTPSHSGTPQPLGPRHRQVSRTQVKRGRPPIIDLPYIQRMKNVMKVLKKEVLDSGIGLT
DLFERLPDRHRDANYYIMIANPISLQDINKKVKTRRYKTFQEFQNDFNLMLTNFRISHRG
DPESIKISNILEKTFTSLARFELSKPDRSFIPEGELRYPLDEVIVNNISYHVGDWALLRN
QNDPQKPIVGQIFRLWKTPDGKQWLNACWYYRPEQTVHRVDRLFYKNEVMKTGQYRDHLV
SNLVGKCYVIHFTRYQRGNPDMKLEGPLFVCEFRYNESDKIFNKIRTWKACLPEEIRDLD
EATIPVNGRKFFKYPSPIRHLLPANATPHDRVPEPTMGSPDAPPLVGAVYMRPKMQRDDL
GEYATSDDCPRYIIRPNDSPEEGQVDIETGTITTNTPTANALPKTGYSSSKLSSLRYNRS
SMSLENQNAIGQQQIPLSRVGSPGAGGPLTVQGLKQHQLQRLQQQQHQYQQQKRSQASRY
NIPTIIDDLTSQASRGNLGNIMIDAASSFVLPISITKNVDVLQRTDLHSQTKRSGREEMF
PWKKTKGEILWFRGPSVIVNERIINSGDPHLSLPLNRWFTTNKKRKLEYEEVEETMEDVT
GKDKDDDGLEPDVENEKESLPGPFVLGLRPSAKFTAHRLSMLRPPSSSS
Sequence of entity 5 (G), FASTA
>6V8O_5 Chromatin structure-remodeling complex protein RSC3 (chains G)
MDIRGRKMKKPPACVQCRKRKIGCDRVKPICGNCMKHNKMDCFYPDVPGQYVPSSSSSSN
TRQVANGPYLNSYYASRRVSKETAALLQKNPELASLEQIREYNTRLQLLNAQNQLNNRSS
AANATLNQQHTQYIPKSVPSLESKPVTSANESSTPLNWVQGPAIFHMLTSPYTQDEIINH
EMNFLKGRLLELQEITGKKITGVNLDLKQDSSAQMQSSHSNRNQEEFLTIKKRKLSEDGV
TDGDGKPIPESERRPHLNEFKDLDPQFLDTNKVFNVFNSAISEEGRNRLWLLPKNINKSS
IFQIQYLIERDPFLFKFFNDLNILIETQFNGPLHDLVASRNSIERNSGISQILKFPSQSI
TQTLINKYLSTITETNSILPILKPKRLLPIVEQLFPSNTINKPNSKDFETIFQVFSVTND
QLLNLGFITLCLLILFESLNSTVLIPLRDDEHLQLFNVLFNYLPLLKSNLTTLRFEIEKR
SMCNIETLRFISLWKYYQFVMDTSSSSSFVIDYDEDMHMACLLSLNHETQNQSHILTWNF
IFKNYCWRHLFLGQLPLLMSEPFTNSTPIIDPLLNNDFELIDFEVNLMKYLQSKDQQLSI
DKIIQLIKLLKNKNIEVSQGCLTTPSIINNIMDSLIYRNSMLYLNFYLLLQFETLKNYAK
FNEILEDFLELSRETLFFVFSNLANIKFAGHEFTFINKSIVVLQTLVLMLLALYQRSFDS
SKRTNDANEISEQTDIHSNNDNSKRIKNKNVIHLIINKIAMLLSDYSKNCKKQNKLIENL
IIKIKTISKYIKNLEENKVTTSADSNYSINNGFSGISAEQLIKLNHELSKISESLIKTDF
YEQRKNSTVSNGVLGAAAPVDSDANSDTFGLTKENFNEVFEAIRS
Sequence of entity 6 (H), FASTA
>6V8O_6 Chromatin structure-remodeling complex subunit RSC4 (chains H)
MVVKKRKLATEAGGSDERPKYLPGKHPKNQEKTPHVDYNAPLNPKSELFLDDWHIPKFNR
FISFTLDVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIKSRDYEYEDGPSNFL
LDVELLTKNCQAYNEYDSLIVKNSMQVVMLIEFEVLKAKNLKRNYLINSEVKAKLLHYLN
KLVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIVHSPMALSIVKQ
NLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLTNYFNYLIQKEFFPELQDL
NERGEINLEFDKFEFENYLAIGGGGPAAAGALAISALDNDIEPESNREDLIDQADYDFNH
FEGLGNGYNRSLLTEDYLLNPNNFKKLIAKPETVQSEVKNERSTTSDIEKTNSLESEHLK
IPKYNVIKSMQKEMQSLSEQHTMEYKPYKLIQQIYIFSSKNLYSQATKPLLGSRPSCNQN
WVEYIFNGNELSQNENAFSFMLQPMQTFLTLQSHLTSSLKDTETLLTINKEPVKSRTSNV
NSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDNDKRNNITEIFDIRLSEGLN
HLMFRCEDKISHETEFMNFWINVLP
Sequence of entity 7 (I, J, K, L), FASTA
>6V8O_7 Chromatin structure-remodeling complex protein RSC8 (chains I, J, K, L)
MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQ
EAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFFNDSSRFKTPKAYKD
TRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFLEKWGLINYQIDPRTKPSLIG
PSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEPQVKKEFPVNLTIKKNVYDSAQD
FNALQDESRNSRQIHKVYICHTCGNESINVRYHNLRARDTNLCSRCFQEGHFGANFQSSD
FIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIE
DNYIREVVGSTLNGKGGDSRDGSVSGSKLMECVNDAVQTLLQGDDKLGKVSDKSREISEK
YIEESQAIIQELVKLTMEKLESKFTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQIL
DLNKSLEELNVSKKLVLISEQVDSGIQLVEKDQEGDDEDGNTATGHGVKRVGKEGEEVGE
GDSIAKLQPQVYKPWSL
Sequence of entity 8 (M), FASTA
>6V8O_8 Chromatin structure-remodeling complex protein RSC6 (chains M)
MVTQTNPVPVTYPTDAYIPTYLPDDKVSNLADLKKLIEMDSRLDLYLTRRRLDTSINLPT
NTKTKDHPPNKEMLRIYVYNTTESSPRSDSGTPADSGKTTWTLRIEGKLLHESANGKHPF
SEFLEGVAVDFKRLKPLGMGKKRKRDSSLSLPLNLQQPEYNDQDSTMGDNDNGEDEDSAE
AESREEIVDALEWNYDENNVVEFDGIDIKRQGKDNLRCSITIQLRGVDGGKVQYSPNLAT
LIGMQTGSVNDAVYSIYKYILINNLFVTEQTEAQDGSNDAEDSSNENNNKNGAGDDDGVE
GSTPKDKPELGEVKLDSLLQKVLDTNAAHLPLMNVVQTVNKLVSPLPPIILDYTIDLSKD
TTYGATTLDVDVSHILHQPQPQPNLQKEEETDAEDTAKLREITKLALQLNSSAQKYQFFH
ELSLHPRETLTHYLWSSKQNELVLQGDQYFNEDAARTSDIYSNNNNDRSLMGNISLLYSQ
GRL
Sequence of entity 9 (N), FASTA
>6V8O_9 Chromatin structure-remodeling complex subunit RSC9 (chains N)
MNSLASNTPLNGTPVSEAPATSSEPVNMFETMVANPIKVSRLQSNGVLTGPAANTKSIHY
SLANFNVFQSLPKETARGVDDLTRMEMALLSGIPEEIKWSLKKYLTYSNKAPYMISLRTL
PDLLPLFKTFILPLERIVEGLNKSSICDSKAMDSLQMGLNALLILRNLAQDTDSVQILVK
DREIKSFILFILKKFQCVATGDNKWQLYEGNATFFNELTHYTLDLMEAISSYIAPAMKDD
HYFQTLVSILNYTKDRYMVISILRSLSRLLVRSKANEESAADNLDHKTLSLIVSFLLLEC
DSELIIASLDFLYQYILPGSQRITELFKSKECSLILEATLPNLLSYNIATPDYHLLQKHK
IRLIKRLKPPAPKEPPNLSEDLFQQLFKLNEPLRSTAWLRCCFEPVQEAEFTQISLWRSY
ESKFGQPVRESGRKLLPAVEFIKNVSNAFNNAAAIVITDPVTGKKRFVIKGIQPRFKALG
IADGERESQVPISALKSKFLNDSKEITPARQNSIPEVKFPQELSDVSKVACTFLCLLSND
TDDGAGSAFCQRIRPLVLHKLADIPPLTLALSEYMENTSGL
Sequence of entity 10 (O), FASTA
>6V8O_10 Chromatin structure-remodeling complex protein RSC58 (chains O)
MTESVGGNKLVDFLVNVQSILNAASVKCHVVDESFPAKFFEKNPDKIYESYCKFIKNRSN
SEGLIRNEDKLVLTTINKRFENGEYEPIQGGFYKLYHDIKLVCTILIHFYPQGTRNYQLV
DKFYKFSSELLLRECCRIGIALTQTNNIKSRSGKLLSGNEMDEYDDDDATELDKIISYDF
IKISMNYTVPISQTYQIRTKDMDLFSSIISKSNLDKRPHELPNTNFKINNVLPQTDIENE
APRLGFVGANTSNIPDPTLPPTEMMTRFLHPNWYALPTTVWLKYGNYNSWAPSFNENGTV
VDSTTRGLIWLERIGYMDLYEKNEKKVKQEELLNTNEEGINRKQNDENNKNVDGKSNGVQ
DDGGDNDNDATIASANSESTENKEQFIIKLQNLYNWTPSNYIGDDEIENFRNGTPDKLVS
DSLLKLKRLRKERILNKVLKPTTEERELYFKVKRILKEVILAKKVSKVPINNVRAFPVLQ
TNYNGSIPVVRAQPGRKRKHKK
Sequence of entity 11 (Q), FASTA
>6V8O_11 Chromatin structure-remodeling complex subunit SFH1 (chains Q)
MSHQNQLIPQAYISNFHNRLTNEDDGIPIFTMAQQTRQHKRAKVVNYAEYDNDLFDEFNM
NGSNFNNADTHYKDNAVSHENTPALTNGVTMDGSEYNVLENMNGADSIISNNKYDAGSNM
VVESLSGLNSNNNASNGPSNKAQAQDIGNAVLPDLQDQHHNPFNILRYPKIRDTFINGKV
VSPYRLNTDQETKANANSGEAIMIPITLDIEHMGHTIKDQFLWNYNDDSISPEEFASIYC
KDLDMTSATLQTQIANIIKEQLKDLENIAATEIMSDLHVIINLTCNLQDRFFEDNFQWNL
NDKSLTPERFATSIVQDLGLTREFIPLISQSLHETILKIKKDWVDGHLIQDHVPNDAAFG
YLSGIRLDIDELGSNWCPRVEILTKEEIQKREIEKERNLRRLKRETDRLSRRGRRRLDDL
ETTMRM
Sequence of entity 12 (R), FASTA
>6V8O_12 Nuclear protein STH1/NPS1 (chains R)
MLQEQSELMSTVMNNTPTTVAALAAVAAASETNGKLGSEEQPEITIPKPRSSAQLEQLLY
RYRAIQNHPKENKLEIKAIEDTFRNISRDQDIYETKLDTLRKSIDKGFQYDEDLLNKHLV
ALQLLEKDTDVPDYFLDLPDTKNDNTTAIEVDYSEKKPIKISADFNAKAKSLGLESKFSN
ATKTALGDPDTEIRISARISNRINELERLPANLGTYSLDDCLEFITKDDLSSRMDTFKIK
ALVELKSLKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPFTAAAQRSVQIRSKVIVPQT
VRLAEELERQQLLEKRKKERNLHLQKINSIIDFIKERQSEQWSRQERCFQFGRLGASLHN
QMEKDEQKRIERTAKQRLAALKSNDEEAYLKLLDQTKDTRITQLLRQTNSFLDSLSEAVR
AQQNEAKILHGEEVQPITDEEREKTDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEW
MVSLYNNHLNGILADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEK
WAPSLNTIIYKGTPNQRHSLQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGH
RMKNAQSKLSFTISHYYRTRNRLILTGTPLQNNLPELWALLNFVLPKIFNSAKTFEDWFN
TPFANTGTQEKLELTEEETLLIIRRLHKVLRPFLLRRLKKEVEKDLPDKVEKVIKCKLSG
LQQQLYQQMLKHNALFVGAGTEGATKGGIKGLNNKIMQLRKICNHPFVFDEVEGVVNPSR
GNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDIMEDFLRMKDLKYMRLDGS
TKTEERTEMLNAFNAPDSDYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDR
AHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKFDNKSTAEEQEAFLRR
LIESETNRDDDDKAELDDDELNDTLARSADEKILFDKIDKERMNQERADAKAQGLRVPPP
RLIQLDELPKVFREDIEEHFKKEDSEPLGRIRQKKRVYYDDGLTEEQFLEAVEDDNMSLE
DAIKKRREARERRRLRQNGTKENEIETLENTPEASETSLIENNSFTAAVDEETNADKETT
ASRSKRRSSRKKRTISIVTAEDKENTQEESTSQENGGAKVEEEVKSSSVEIINGSESKKK
KPKLTVKIKLNKTTVLENNDGKRAEEKPESKSPAKKTAAKKTKTKSKSLGIFPTVEKLVE
EMREQLDEVDSHPRTSIFEKLPSKRDYPDYFKVIEKPMAIDIILKNCKNGTYKTLEEVRQ
ALQTMFENARFYNEEGSWVYVDADKLNEFTDEWFKEHSS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
Primary citation
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. Patel, A.B., Moore, C.M., Greber, B.J. et al. Elife (2019) 8. DOI 10.7554/eLife.54449 · PubMed
Other PDB entries of the same protein (UniProt Q9URQ5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6K15 3.4 Å, RSC substrate-recruitment module
- 6KW3 7.13 Å, The ClassA RSC-Nucleosome Complex
- 6KW4 7.55 Å, The ClassB RSC-Nucleosome Complex
- 6KW5 10.13 Å, The ClassC RSC-Nucleosome Complex
- 6TDA 15.0 Å, Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome
- 6V92 20.0 Å, Rsc-ncp
Browse structure collections
About this viewer
MolViewer shows 6V8O directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.