6W9S: OTU deubiquitinase from Escherichia albertii

Crystal structure of an OTU deubiquitinase from Escherichia albertii bound to ubiquitin. Determined by X-ray diffraction at 2.1 Å resolution. Released 1 Jul 2020.

Method: X-ray diffraction
Resolution: 2.1 Å
Organisms: Escherichia albertii (strain TW07627), Homo sapiens
Chains: 2
Atoms: 2,036
Mol. weight: 29.35 kDa
Released: 1 Jul 2020

Explore 6W9S in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6W9S contains 13 α-helices and 11 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	196-209	14
α-helix	217-232	16
β-strand	237-241	5	1
β-strand	254-258	5	1
β-strand	263-267	5	1
β-strand	275-277	3	1
α-helix	278	1
α-helix	285-297	13
α-helix	306-308	3
α-helix	313-327	15
α-helix	329-332	4
α-helix	333-343	11
α-helix	346-358	13

Chain B: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	1-7	7	2
β-strand	12-17	6	2
β-strand	22	1	3
α-helix	23-34	12
α-helix	38-40	3
β-strand	42-45	4	2
β-strand	48-49	2	2
α-helix	50-51	2
β-strand	55	1	3
α-helix	56-59	4
β-strand	66-70	5	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
OTU domain-containing protein EschOTU	A	protein	179	Escherichia albertii (strain TW07627)	B1EF49
Ubiquitin	B	protein	78	Homo sapiens	F5H388 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6W9S_1 OTU domain-containing protein EschOTU (chains A)
SSPQSVFSDSVSSSRLELKKQIIKALDLDYWQGSGGEIMPLVLIDFYKRHNININIYLNH
CKVNNFDKKAINLINAGNHYNALTMNSRGNIERIDVPGDGNCLYHAVVKSHQITRKPKPY
GNELQKDKPEWCILKESLKTHFDKDFDQFVEQVKCILISENTHEANKILDKVAQYSGVK

Sequence of entity 2 (B), FASTA

>6W9S_2 Ubiquitin (chains B)
GPMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSD
YNIQKESTLHLVLRLRGX

Primary citation

Identification and characterization of diverse OTU deubiquitinases in bacteria. Schubert, A.F., Nguyen, J.V., Franklin, T.G. et al. EMBO J (2020) 39:e105127-e105127. DOI 10.15252/embj.2020105127 · PubMed

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