6WG3: Human Cohesin-NIPBL-DNA complex
Cryo-EM structure of human Cohesin-NIPBL-DNA complex. Determined by electron microscopy at 5.3 Å resolution. Released 20 May 2020.
- Method
- Electron microscopy
- Resolution
- 5.3 Å
- Organism
- Homo sapiens
- Chains
- 7
- Atoms
- 31,683
- Mol. weight
- 723.45 kDa
- Ligands
- ANP
- Released
- 20 May 2020
Explore 6WG3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6WG3 contains 185 α-helices and 63 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 22 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-10 | 8 | 1 |
| β-strand | 12 | 1 | 2 |
| β-strand | 18-20 | 3 | 1 |
| α-helix | 21-24 | 4 | |
| β-strand | 27-31 | 5 | 3 |
| α-helix | 39-48 | 10 | |
| α-helix | 53-56 | 4 | |
| β-strand | 65 | 1 | 2 |
| β-strand | 79-80 | 2 | 4 |
| β-strand | 81-86 | 6 | 1 |
| β-strand | 90-93 | 4 | 1 |
| β-strand | 94-99 | 6 | 4 |
| β-strand | 102-107 | 6 | 4 |
| β-strand | 111-112 | 2 | 4 |
| α-helix | 114-124 | 11 | |
| β-strand | 134 | 1 | 3 |
| α-helix | 141-143 | 3 | |
| α-helix | 148-158 | 11 | |
| α-helix | 165-201 | 37 | |
| α-helix | 492-510 | 19 | |
| β-strand | 517 | 1 | 5 |
| α-helix | 519-522 | 4 | |
| β-strand | 523-525 | 3 | 6 |
| α-helix | 531-538 | 8 | |
| α-helix | 539-543 | 5 | |
| β-strand | 545-547 | 3 | 5 |
| α-helix | 550-563 | 14 | |
| α-helix | 565-567 | 3 | |
| β-strand | 568-572 | 5 | 5 |
| α-helix | 579-581 | 3 | |
| α-helix | 584-587 | 4 | |
| β-strand | 591-593 | 3 | 7 |
| α-helix | 594-597 | 4 | |
| β-strand | 598-600 | 3 | 6 |
| α-helix | 605-613 | 9 | |
| β-strand | 617-619 | 3 | 7 |
| α-helix | 622-630 | 9 | |
| β-strand | 638-639 | 2 | 7 |
| β-strand | 645-646 | 2 | 7 |
| β-strand | 652-653 | 2 | 7 |
| α-helix | 1032-1088 | 57 | |
| β-strand | 1096-1100 | 5 | 8 |
| β-strand | 1111-1115 | 5 | 8 |
| α-helix | 1130-1147 | 18 | |
| β-strand | 1152-1156 | 5 | 3 |
| α-helix | 1164-1178 | 15 | |
| β-strand | 1183-1187 | 5 | 3 |
| α-helix | 1191-1194 | 4 | |
| β-strand | 1199-1204 | 6 | 3 |
| β-strand | 1214-1219 | 6 | 3 |
Chain B: 31 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 9 |
| β-strand | 16-17 | 2 | 9 |
| α-helix | 21-23 | 3 | |
| β-strand | 28-29 | 2 | 10 |
| α-helix | 39-49 | 11 | |
| α-helix | 52-55 | 4 | |
| α-helix | 58-64 | 7 | |
| β-strand | 76-82 | 7 | 9 |
| β-strand | 96-102 | 7 | 9 |
| β-strand | 107-111 | 5 | 9 |
| β-strand | 114 | 1 | 9 |
| α-helix | 120-128 | 9 | |
| β-strand | 139 | 1 | 10 |
| α-helix | 145-147 | 3 | |
| α-helix | 152-163 | 12 | |
| α-helix | 167-241 | 75 | |
| α-helix | 495-499 | 5 | |
| α-helix | 503-522 | 20 | |
| α-helix | 526-530 | 5 | |
| β-strand | 532-535 | 4 | 11 |
| α-helix | 536-538 | 3 | |
| β-strand | 540-542 | 3 | 12 |
| α-helix | 544-546 | 3 | |
| α-helix | 547-554 | 8 | |
| α-helix | 557-559 | 3 | |
| β-strand | 560-563 | 4 | 11 |
| α-helix | 566-578 | 13 | |
| α-helix | 581-582 | 2 | |
| β-strand | 586-589 | 4 | 11 |
| α-helix | 599-601 | 3 | |
| β-strand | 606-608 | 3 | 13 |
| α-helix | 609-612 | 4 | |
| β-strand | 613-615 | 3 | 12 |
| α-helix | 617-619 | 3 | |
| α-helix | 620-627 | 8 | |
| β-strand | 630-633 | 4 | 13 |
| α-helix | 636-645 | 10 | |
| β-strand | 649-651 | 3 | 13 |
| β-strand | 657-658 | 2 | 13 |
| β-strand | 664-666 | 3 | 5 |
| α-helix | 676-682 | 7 | |
| α-helix | 928-946 | 19 | |
| α-helix | 964-978 | 15 | |
| α-helix | 986-1047 | 62 | |
| β-strand | 1052-1057 | 6 | 14 |
| β-strand | 1096-1101 | 6 | 14 |
| α-helix | 1117-1134 | 18 | |
| β-strand | 1139-1142 | 4 | 10 |
| α-helix | 1145-1147 | 3 | |
| α-helix | 1151-1164 | 14 | |
| β-strand | 1169-1172 | 4 | 10 |
| α-helix | 1178-1181 | 4 | |
| β-strand | 1188-1192 | 5 | 15 |
| β-strand | 1195-1199 | 5 | 15 |
| α-helix | 1203-1211 | 9 | |
Chain C: 15 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-22 | 8 | |
| α-helix | 29-34 | 6 | |
| α-helix | 38-45 | 8 | |
| α-helix | 53-85 | 33 | |
| β-strand | 158 | 1 | 16 |
| α-helix | 167-170 | 4 | |
| α-helix | 325-326 | 2 | |
| α-helix | 334-342 | 9 | |
| α-helix | 345-347 | 3 | |
| β-strand | 348 | 1 | 17 |
| β-strand | 353 | 1 | 18 |
| α-helix | 354-355 | 2 | |
| α-helix | 358-365 | 8 | |
| α-helix | 369-374 | 6 | |
| α-helix | 383-391 | 9 | |
| α-helix | 559-571 | 13 | |
| β-strand | 579 | 1 | 19 |
| α-helix | 581-584 | 4 | |
| α-helix | 590-605 | 16 | |
| β-strand | 609-612 | 4 | 19 |
| β-strand | 621-624 | 4 | 19 |
Chain D: 50 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 87-92 | 6 | |
| α-helix | 98-111 | 14 | |
| α-helix | 113-126 | 14 | |
| α-helix | 136-141 | 6 | |
| α-helix | 144-153 | 10 | |
| α-helix | 169-187 | 19 | |
| α-helix | 193-195 | 3 | |
| α-helix | 199-212 | 14 | |
| α-helix | 216-256 | 41 | |
| α-helix | 261-291 | 31 | |
| α-helix | 292-296 | 5 | |
| α-helix | 297-299 | 3 | |
| α-helix | 305-321 | 17 | |
| α-helix | 323-326 | 4 | |
| α-helix | 329-338 | 10 | |
| α-helix | 344-359 | 16 | |
| α-helix | 368-381 | 14 | |
| β-strand | 384 | 1 | 17 |
| α-helix | 387-403 | 17 | |
| α-helix | 410-419 | 10 | |
| β-strand | 422 | 1 | 18 |
| α-helix | 425-439 | 15 | |
| α-helix | 459-474 | 16 | |
| α-helix | 482-488 | 7 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-505 | 7 | |
| α-helix | 519-537 | 19 | |
| α-helix | 541-542 | 2 | |
| α-helix | 554-582 | 29 | |
| α-helix | 586-592 | 7 | |
| α-helix | 595-598 | 4 | |
| α-helix | 603-606 | 4 | |
| α-helix | 610-626 | 17 | |
| α-helix | 630-643 | 14 | |
| α-helix | 651-677 | 27 | |
| α-helix | 685-704 | 20 | |
| α-helix | 713-726 | 14 | |
| α-helix | 731-750 | 20 | |
| α-helix | 760-779 | 20 | |
| α-helix | 785-801 | 17 | |
| α-helix | 804-806 | 3 | |
| α-helix | 823-837 | 15 | |
| α-helix | 855-881 | 27 | |
| α-helix | 887-891 | 5 | |
| α-helix | 897-912 | 16 | |
| α-helix | 916-938 | 23 | |
| α-helix | 947-962 | 16 | |
| α-helix | 968-985 | 18 | |
| α-helix | 1003-1008 | 6 | |
| α-helix | 1016-1026 | 11 | |
| α-helix | 1032-1036 | 5 | |
| α-helix | 1043-1051 | 9 | |
Chain E: 67 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1199-1215 | 17 | |
| α-helix | 1235-1246 | 12 | |
| α-helix | 1248-1250 | 3 | |
| α-helix | 1258-1272 | 15 | |
| α-helix | 1273-1275 | 3 | |
| α-helix | 1295-1318 | 24 | |
| α-helix | 1330-1343 | 14 | |
| α-helix | 1344-1348 | 5 | |
| α-helix | 1349-1352 | 4 | |
| α-helix | 1381-1403 | 23 | |
| α-helix | 1408-1419 | 12 | |
| α-helix | 1420-1423 | 4 | |
| α-helix | 1428-1444 | 17 | |
| α-helix | 1449-1457 | 9 | |
| β-strand | 1473 | 1 | 20 |
| β-strand | 1487 | 1 | 20 |
| α-helix | 1490-1500 | 11 | |
| α-helix | 1525-1550 | 26 | |
| α-helix | 1559-1571 | 13 | |
| α-helix | 1581-1596 | 16 | |
| α-helix | 1604-1627 | 24 | |
| α-helix | 1647-1665 | 19 | |
| α-helix | 1669-1689 | 21 | |
| α-helix | 1709-1727 | 19 | |
| α-helix | 1750-1763 | 14 | |
| α-helix | 1767-1769 | 3 | |
| α-helix | 1770-1780 | 11 | |
| α-helix | 1786-1802 | 17 | |
| α-helix | 1810-1820 | 11 | |
| β-strand | 1822 | 1 | 16 |
| α-helix | 1825-1841 | 17 | |
| α-helix | 1850-1854 | 5 | |
| α-helix | 1855-1857 | 3 | |
| α-helix | 1863-1878 | 16 | |
| α-helix | 1885-1894 | 10 | |
| α-helix | 1901-1913 | 13 | |
| α-helix | 1923-1940 | 18 | |
| α-helix | 1946-1957 | 12 | |
| α-helix | 1966-1985 | 20 | |
| α-helix | 1999-2015 | 17 | |
| α-helix | 2018-2020 | 3 | |
| α-helix | 2024-2032 | 9 | |
| α-helix | 2038-2054 | 17 | |
| α-helix | 2055-2057 | 3 | |
| α-helix | 2063-2077 | 15 | |
| α-helix | 2082-2098 | 17 | |
| α-helix | 2103-2125 | 23 | |
| α-helix | 2133-2153 | 21 | |
| α-helix | 2169-2181 | 13 | |
| α-helix | 2187-2202 | 16 | |
| α-helix | 2204-2208 | 5 | |
| α-helix | 2210-2219 | 10 | |
| α-helix | 2228-2253 | 26 | |
| α-helix | 2259-2261 | 3 | |
| α-helix | 2274-2279 | 6 | |
| α-helix | 2283-2288 | 6 | |
| α-helix | 2296-2309 | 14 | |
| α-helix | 2320-2325 | 6 | |
| α-helix | 2332-2348 | 17 | |
| α-helix | 2352-2355 | 4 | |
| α-helix | 2358-2371 | 14 | |
| α-helix | 2393-2398 | 6 | |
| α-helix | 2403-2419 | 17 | |
| α-helix | 2425-2437 | 13 | |
| α-helix | 2444-2470 | 27 | |
| α-helix | 2534-2557 | 24 | |
| α-helix | 2561-2566 | 6 | |
| α-helix | 2578-2581 | 4 | |
| α-helix | 2589-2600 | 12 | |
| α-helix | 2609-2626 | 18 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Structural maintenance of chromosomes protein 1A | A | protein | 1233 | Homo sapiens | Q14683 (AlphaFold model) |
| Structural maintenance of chromosomes protein 3 | B | protein | 1217 | Homo sapiens | Q9UQE7 (AlphaFold model) |
| Double-strand-break repair protein rad21 homolog | C | protein | 631 | Homo sapiens | O60216 (AlphaFold model) |
| Cohesin subunit SA-1 | D | protein | 1272 | Homo sapiens | Q8WVM7 (AlphaFold model) |
| Nipped-B-like protein | E | protein | 1652 | Homo sapiens | Q6KC79 |
| DNA (51-mer) | F | DNA | 51 | Homo sapiens | |
| DNA (51-mer) | G | DNA | 51 | Homo sapiens | |
Sequence of entity 1 (A), FASTA
>6WG3_1 Structural maintenance of chromosomes protein 1A (chains A)
MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT
LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE
LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE
DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK
ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK
AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS
QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK
IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV
MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK
NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY
EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK
AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE
QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF
CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ
TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG
ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE
DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI
AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN
IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL
LFAIHSYKPAPFFVLDQIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL
IGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ
Sequence of entity 2 (B), FASTA
>6WG3_2 Structural maintenance of chromosomes protein 3 (chains B)
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ
RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND
VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK
ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLD
ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIK
QRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER
GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL
EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ
QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF
ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY
PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH
RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ
IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE
LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL
DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKS
MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL
SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV
LELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERG
SGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFY
LFDQIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDV
ITAEMAKDFVEDDTTHG
Sequence of entity 3 (C), FASTA
>6WG3_3 Double-strand-break repair protein rad21 homolog (chains C)
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLL
LGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQP
LPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMAEGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGG
IFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPASVDPVEPMPTMTDQTTLVPNE
EEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEF
ENPEVPREDQQQQHQQRDVIDEPIIEEPSALQESVMEASRTNIDESAMPPPPPQGVKRKA
GQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE
DEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSF
LVLKKQQAIELTQEEPYSDIIATPGPRFHII
Sequence of entity 4 (D), FASTA
>6WG3_4 Cohesin subunit SA-1 (chains D)
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRI
EAGIRGAGRGRANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDL
INFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCE
FIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNL
SIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRY
RDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTN
RELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLV
YSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEH
AAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAH
PPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFD
LEIYSTGRMEKHLDALLKQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQ
LIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLL
KTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVKSFLAVCQQCL
SNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFID
QDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDY
GDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFA
LTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKK
TVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKG
RPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEH
GSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFED
VMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMFGA
PMRSGALEVLFQ
Sequence of entity 5 (E), FASTA
>6WG3_5 Nipped-B-like protein (chains E)
MSYYHHHHHHPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDN
LEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKN
IQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDV
IERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCD
IVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLI
LEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSN
AEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLST
VNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQG
SIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAM
KSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDD
ACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDM
QRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKIL
RDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILN
ITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADS
DNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILE
LVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNR
YYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDK
VLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQ
VLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFH
TQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGF
IHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLIS
LLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESM
VKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAP
LIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQ
TLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITS
LLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIA
ICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDII
YKKIALTSANKLTNKVVQTLRSLYAAKDGTSS
Sequence of entity 6 (F), FASTA
>6WG3_6 DNA (51-MER) (chains F)
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Sequence of entity 7 (G), FASTA
>6WG3_7 DNA (51-MER) (chains G)
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ANP | Phosphoaminophosphonic acid-adenylate ester | C10 H17 N6 O12 P3 | 2 |
Primary citation
Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Shi, Z., Gao, H., Bai, X.C. et al. Science (2020) 368:1454-1459. DOI 10.1126/science.abb0981 · PubMed
Other PDB entries of the same protein (UniProt Q14683 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8ROE 1.36 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-bound conformation
- 8ROD 1.5 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Open/closed P-loop conformation
- 8ROF 1.65 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-Mg-bound conformation
- 8RO9 1.77 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Open/closed P-loop conformation
- 8ROC 1.85 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Apo closed P-loop conformation
- 8RO8 1.9 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Apo closed P-loop conformation
- 8ROG 1.94 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation
- 8RO7 2.09 Å, Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Open/closed P-loop conformation
- 8RO6 2.2 Å, Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation
- 6WG4 2.31 Å, Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation
- 8ROA 2.44 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ADP-bound conformation
- 8ROB 2.5 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation
Browse structure collections
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