6WNL: Protein artemis

human Artemis/SNM1C catalytic domain, crystal form 2. Determined by X-ray diffraction at 2.37 Å resolution. Released 1 Jul 2020.

Method: X-ray diffraction
Resolution: 2.37 Å
Organism: Homo sapiens
Chains: 2
Atoms: 5,995
Mol. weight: 86.85 kDa
Ligands: ZN
Released: 1 Jul 2020

Explore 6WNL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6WNL contains 36 α-helices and 48 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	1
α-helix	21-25	5
β-strand	29-30	2	1
α-helix	36-38	3
α-helix	45-52	8
β-strand	59-61	3	1
α-helix	63-71	9
α-helix	73-81	9
β-strand	82-84	3	1
β-strand	91-96	6	2
β-strand	103-112	10	2
β-strand	120-125	6	2
β-strand	131-133	3	2
α-helix	144-146	3
α-helix	148-150	3
β-strand	151-152	2	3
β-strand	155-156	2	3
β-strand	161-164	4	2
α-helix	171-173	3
β-strand	175	1	4
α-helix	179-194	16
β-strand	200-204	5	5
α-helix	213-223	11
α-helix	226	1
β-strand	227-228	2	5
α-helix	233-235	3
α-helix	239-242	4
β-strand	245-246	2	5
β-strand	253-254	2	5
α-helix	261-266	6
β-strand	276-277	2	6
β-strand	280-281	2	6
α-helix	282	1
β-strand	283-290	8	5
β-strand	294	1	4
β-strand	304-308	5	5
β-strand	311-315	5	5
α-helix	322-332	11
β-strand	336-339	4	2
α-helix	348-355	8
α-helix	356-358	3

Chain B: 18 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	8	1	7
β-strand	11	1	7
β-strand	14-16	3	8
α-helix	21-25	5
β-strand	28-30	3	8
α-helix	36-38	3
α-helix	45-52	8
β-strand	59-61	3	8
α-helix	63-71	9
α-helix	73-81	9
β-strand	82-84	3	8
β-strand	91-96	6	9
β-strand	103-112	10	9
β-strand	120-125	6	9
β-strand	131-133	3	9
α-helix	144-146	3
α-helix	148-150	3
β-strand	151-152	2	10
β-strand	155-156	2	10
β-strand	161-164	4	9
α-helix	171-173	3
β-strand	175	1	11
α-helix	179-194	16
β-strand	200-204	5	12
α-helix	213-223	11
α-helix	226	1
β-strand	227-228	2	12
α-helix	233-235	3
α-helix	239-242	4
β-strand	245-246	2	12
β-strand	253-254	2	12
α-helix	261-266	6
β-strand	276-277	2	13
β-strand	280-281	2	13
α-helix	282	1
β-strand	283-290	8	12
β-strand	294	1	11
β-strand	304-306	3	12
β-strand	311-315	5	12
α-helix	322-332	11
β-strand	336-339	4	9
α-helix	348-355	8
α-helix	356-358	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein artemis	A, B	protein	375	Homo sapiens	Q96SD1 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6WNL_1 Protein artemis (chains A, B)
SSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYC
SPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVM
FLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREE
CLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEI
LHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKT
NVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRS
SQSTEPKKGENLYFQ

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Primary citation

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features. Karim, M.F., Liu, S., Laciak, A.R. et al. J Biol Chem (2020) 295:12368-12377. DOI 10.1074/jbc.RA120.014136 · PubMed

Other PDB entries of the same protein (UniProt Q96SD1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6TT5 1.5 Å, Crystal structure of DCLRE1C/Artemis
7AFU 1.56 Å, The structure of Artemis variant H33A
7AF1 1.7 Å, The structure of Artemis/SNM1C/DCLRE1C with 2 Zinc ions
7AFS 1.7 Å, The structure of Artemis variant D37A
7AGI 1.7 Å, The structure of Artemis variant H35D
7APV 1.95 Å, Structure of Artemis/DCLRE1C/SNM1C in complex with Ceftriaxone
6WO0 1.97 Å, human Artemis/SNM1C catalytic domain, crystal form 1
7ABS 1.97 Å, Structure of human DCLRE1C/Artemis in complex with DNA - re-evaluation of 6WO0
4HTP 2.25 Å, Crystal structure of the DBD domain of human DNA ligase IV bound to Artemis peptide
3W1B 2.4 Å, Crystal Structure of Human DNA ligase IV-Artemis Complex (Mercury Derivative)
3W1G 2.55 Å, Crystal Structure of Human DNA ligase IV-Artemis Complex (Native)
7SGL 3.0 Å, DNA-PK complex of DNA end processing

Browse structure collections

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