Human VKOR with phenindione. Determined by X-ray diffraction at 2.7 Å resolution. Released 11 Nov 2020.
Explore 6WV6 in 3D Show helices and sheets RCSB PDB PDBe
6WV6 contains 15 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-6 | 4 | |
| β-strand | 11-22 | 12 | 1 |
| β-strand | 25-36 | 12 | 1 |
| β-strand | 41-48 | 8 | 1 |
| α-helix | 57-59 | 3 | |
| α-helix | 69-71 | 3 | |
| β-strand | 73 | 1 | 1 |
| α-helix | 76-81 | 6 | |
| α-helix | 83-86 | 4 | |
| β-strand | 92-100 | 9 | 1 |
| β-strand | 105-115 | 11 | 1 |
| β-strand | 118-128 | 11 | 1 |
| β-strand | 141 | 1 | 2 |
| β-strand | 147 | 1 | 3 |
| α-helix | 152-177 | 26 | |
| β-strand | 187 | 1 | 4 |
| β-strand | 191 | 1 | 4 |
| α-helix | 194-197 | 4 | |
| α-helix | 200-202 | 3 | |
| β-strand | 203 | 1 | 5 |
| α-helix | 204-206 | 3 | |
| α-helix | 208-211 | 4 | |
| β-strand | 221 | 1 | 5 |
| α-helix | 222-237 | 16 | |
| β-strand | 239 | 1 | 3 |
| α-helix | 242-265 | 24 | |
| α-helix | 266-270 | 5 | |
| β-strand | 273 | 1 | 4 |
| α-helix | 275-295 | 21 | |
| β-strand | 300-307 | 8 | 1 |
| β-strand | 312-322 | 11 | 1 |
| β-strand | 323 | 1 | 2 |
| β-strand | 328-339 | 12 | 1 |
| α-helix | 348-349 | 2 | |
| β-strand | 351-360 | 10 | 1 |
| β-strand | 369-379 | 11 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Vitamin K epoxide reductase, termini restrained by green fluorescent protein | A | protein | 390 | Aequorea victoria, Homo sapiens | Q9BQB6 (AlphaFold model) |
>6WV6_1 Vitamin K epoxide reductase, termini restrained by green fluorescent protein (chains A) MSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTL VTTLXVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNR IELKGIDFKEDGNILGHKLEYNSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYR ALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTR WASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQENSHNV YITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKD PNEKRDHMVLLEFVTAAGITHHHHHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| OLC | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | C21 H40 O4 | 2 |
| UAS | Phenindione | C15 H10 O2 | 1 |
Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Liu, S., Li, S., Shen, G. et al. Science (2021) 371. DOI 10.1126/science.abc5667 · PubMed
Other PDB entries of the same protein (UniProt Q9BQB6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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