6XTE: Human karyopherin RanBP5

Human karyopherin RanBP5 (isoform-1). Determined by X-ray diffraction at 2.27 Å resolution. Released 22 Apr 2020.

Method
X-ray diffraction
Resolution
2.27 Å
Organisms
Homo sapiens, Actinomycetia
Chains
2
Atoms
8,565
Mol. weight
124.46 kDa
Ligands
NI
Released
22 Apr 2020

Explore 6XTE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XTE contains 74 α-helices and 5 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 74 helices, 5 β-strands

ElementResiduesLengthSheet
α-helix22-3615
α-helix41-5212
α-helix56-6813
α-helix74-9017
α-helix92-954
α-helix101-11717
α-helix121-13616
β-strand13911
β-strand14511
α-helix148-15912
α-helix163-17513
α-helix188-20013
α-helix206-22015
α-helix226-2316
α-helix233-2353
α-helix236-24712
α-helix253-26412
α-helix266-2727
α-helix273-28412
α-helix291-30717
α-helix309-3124
α-helix316-33116
α-helix353-36816
α-helix370-38516
α-helix390-40213
α-helix404-4074
α-helix415-42410
α-helix425-4273
α-helix431-44717
α-helix451-46919
α-helix474-48916
α-helix493-4964
α-helix497-4993
α-helix500-52021
α-helix525-54117
α-helix542-5487
α-helix549-56214
α-helix566-5683
α-helix569-58618
α-helix588-60720
α-helix619-63315
α-helix634-6407
α-helix641-65212
α-helix654-6563
β-strand658-65922
β-strand676-67832
α-helix681-6833
β-strand686-68832
α-helix690-6923
α-helix693-70917
α-helix711-7144
α-helix715-7173
α-helix718-7258
α-helix727-7304
α-helix735-75521
α-helix757-77519
α-helix781-79818
α-helix805-83228
α-helix840-87132
α-helix872-8754
α-helix876-8794
α-helix883-8897
α-helix896-91217
α-helix916-9238
α-helix925-9317
α-helix937-95317
α-helix956-9583
α-helix959-97416
α-helix984-100017
α-helix1002-10043
α-helix1007-101711
α-helix1018-10203
α-helix1024-103916
α-helix1044-10463
α-helix1048-10503
α-helix1053-10619
α-helix1075-108612
α-helix1090-10989
α-helix1102-111413

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin-5Aprotein1096Homo sapiensO00410 (AlphaFold model)
AntipainCprotein4Actinomycetia
Sequence of entity 1 (A), FASTA
>6XTE_1 Importin-5 (chains A)
AMAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQM
AAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLI
DEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCM
QDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLV
EIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIV
AQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKE
HIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACN
AVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPY
LDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHI
VENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQI
SYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVN
LGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRV
AAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMG
DGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTK
VSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFK
YAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSK
TKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIE
SNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQ
LSPEQQAAIQELLNSA
Sequence of entity 2 (C), FASTA
>6XTE_2 Antipain (chains C)
FRVR

Ligands and cofactors

IDNameFormulaCopies
NINickel (II) ionNi2

Water and common crystallization additives (CL) are not listed.

Primary citation

X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. Swale, C., Da Costa, B., Sedano, L. et al. J Mol Biol (2020) 432:3353-3359. DOI 10.1016/j.jmb.2020.03.021 · PubMed

Other PDB entries of the same protein (UniProt O00410 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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