6XWT: Drosophila melanogaster CENP-A/H4

drosophila melanogaster CENP-A/H4 bound to N-terminal CAL1 fragment. Determined by X-ray diffraction at 3.47 Å resolution. Released 1 Apr 2020.

Method
X-ray diffraction
Resolution
3.47 Å
Organism
Drosophila melanogaster
Chains
6
Atoms
2,803
Mol. weight
294.28 kDa
Released
1 Apr 2020

Explore 6XWT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XWT contains 16 α-helices and 4 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 1 β-strand

ElementResiduesLengthSheet
α-helix50-6415
α-helix74-10128
β-strand106-10721
α-helix109-11911
Chain B: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix32-4110
β-strand46-4721
α-helix51-7626
α-helix84-929
Chain C: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix50-6314
α-helix74-10128
β-strand106-10722
α-helix109-11911
Chain D: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix33-419
β-strand46-4722
α-helix51-7626
α-helix84-929
Chains E and F: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix18-2912
α-helix39-435

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Histone H3-like centromeric protein cidA, Cprotein225Drosophila melanogasterQ9V6Q2 (AlphaFold model)
Histone H4B, Dprotein103Drosophila melanogasterP84040 (AlphaFold model)
Chromosome alignment defect 1E, Fprotein979Drosophila melanogasterQ9VEN2 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>6XWT_1 Histone H3-like centromeric protein cid (chains A, C)
MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTL
RRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRR
RKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAM
QESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF
Sequence of entity 2 (B, D), FASTA
>6XWT_2 Histone H4 (chains B, D)
MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Sequence of entity 3 (E, F), FASTA
>6XWT_3 Chromosome alignment defect 1 (chains E, F)
MANAVVDEETLEAMVYERSKAWSSKMADFASLEDGMEIDVAEFDNLFHGEDEDPDLDDVA
KEAVEDNVPDEAKLEMGHINATSVTELTLILCANEDNEAKAEIEEILNQTVPVVEEHKRK
WREAGLDRILDTFDEKQIEHHVGRWMRRHNSVYLEASPPKYLPPHHNSISDESDESMHSI
DTARYIQQSRRRNAHMTNKNMTTIKMYRKHSHKRDELRAKYAYGDEQEHRHHMQAVLLRR
RERERQLAYLASTPMQCVYSSGHHMRRKNLRKRRINSWMFDSASSSEEDTSFGGCDCHSC
RRHYALSRSVYQSCPYGRGQREYHHRQMASRTMHTMRRQHTFDMEMDLRPRLPENECSCC
NSDRLCSNVIHIANSSTEEWVVENRSNHLTQETQEKTRKQKHQPMDARKVSHQPVCSKGH
EQKPLSSKATSVSKLVLSKEKYMQMFDSESSDEDNALAKKGLLCCSDKKKGMTFPTPNAA
GKITHPTSSAKKAIRKEARPNGLAQIQEEGPTATNSPIESTYLPVAHMKSVSIDGSSGTS
ATFESPAKKAPKRGIRETSPLNGNELQQLISTIPIADEKASSLMEKVDNCIGRESFDDRN
KDFMHMENSSTKTAVEKSTKQKRVSGKKSEIPKSIITNNEILEKNSTETLSEKQVAAKAK
KQSVRKTGATGKPSTSRLKKSEKTKTTSSVTSTSKLEQVREEESDVSSEVLAKPKPQCST
TASILKQGGDGASNSEDDLQIALAMSKATYKEEQQKRKKTKREPSNKQPQSPAEKSMTVF
NNQSVACNSTALANDTACYRVLPKRRGVKRAAAVSTTEEKTATNSSSSPTSSLEEMGSPT
GGDPDCTVVTSTTGCEPPASERQEIPATIKITKRGILLHSPSAPEGASFTLTEQGLGKII
GERWARKYLKYHIGSRSFDSRHSVYYQPTPQLAAALSAPQDAQNIGNISGSSASDDDIFE
QINRYGTVYSILENNSGDK

Primary citation

Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Medina-Pritchard, B., Lazou, V., Zou, J. et al. EMBO J (2020) 39:e103234-e103234. DOI 10.15252/embj.2019103234 · PubMed

Other PDB entries of the same protein (UniProt Q9V6Q2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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