Human COX-1 Crystal Structure. Determined by X-ray diffraction at 3.36 Å resolution. Released 26 Feb 2020.
Explore 6Y3C in 3D Show helices and sheets RCSB PDB PDBe
6Y3C contains 48 α-helices and 31 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 32-34 | 3 | |
| α-helix | 35-38 | 4 | |
| α-helix | 45 | 1 | |
| β-strand | 46-50 | 5 | 1 |
| β-strand | 54-58 | 5 | 1 |
| β-strand | 64-65 | 2 | 2 |
| β-strand | 71-72 | 2 | 2 |
| α-helix | 74-80 | 7 | |
| α-helix | 83-85 | 3 | |
| α-helix | 86-92 | 7 | |
| α-helix | 97-104 | 8 | |
| α-helix | 108-121 | 14 | |
| β-strand | 130-131 | 2 | 3 |
| α-helix | 139-143 | 5 | |
| β-strand | 147 | 1 | 4 |
| β-strand | 149-150 | 2 | 3 |
| α-helix | 153-156 | 4 | |
| β-strand | 161 | 1 | 5 |
| β-strand | 164 | 1 | 5 |
| α-helix | 171-173 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-182 | 5 | |
| β-strand | 183 | 1 | 6 |
| β-strand | 189 | 1 | 7 |
| β-strand | 194 | 1 | 8 |
| β-strand | 195 | 1 | 9 |
| α-helix | 196-206 | 11 | |
| β-strand | 212 | 1 | 10 |
| β-strand | 220 | 1 | 4 |
| β-strand | 221 | 1 | 10 |
| α-helix | 231-234 | 4 | |
| α-helix | 239-244 | 6 | |
| β-strand | 245 | 1 | 11 |
| α-helix | 251 | 1 | |
| β-strand | 252 | 1 | 11 |
| α-helix | 253 | 1 | |
| β-strand | 255-257 | 3 | 12 |
| β-strand | 260-262 | 3 | 12 |
| α-helix | 263-264 | 2 | |
| β-strand | 265 | 1 | 13 |
| α-helix | 275-276 | 2 | |
| β-strand | 285 | 1 | 13 |
| α-helix | 292-294 | 3 | |
| α-helix | 296-319 | 24 | |
| α-helix | 325-343 | 19 | |
| α-helix | 344-348 | 5 | |
| α-helix | 349-353 | 5 | |
| α-helix | 358-359 | 2 | |
| α-helix | 363-366 | 4 | |
| β-strand | 378 | 1 | 3 |
| α-helix | 379-384 | 6 | |
| α-helix | 388-390 | 3 | |
| β-strand | 395 | 1 | 14 |
| β-strand | 402 | 1 | 14 |
| α-helix | 404-407 | 4 | |
| α-helix | 413-426 | 14 | |
| β-strand | 430 | 1 | 9 |
| α-helix | 431 | 1 | |
| β-strand | 432 | 1 | 7 |
| α-helix | 433 | 1 | |
| β-strand | 440 | 1 | 6 |
| α-helix | 442-444 | 3 | |
| α-helix | 445-457 | 13 | |
| α-helix | 460-462 | 3 | |
| α-helix | 463-469 | 7 | |
| α-helix | 473-475 | 3 | |
| α-helix | 479-482 | 4 | |
| α-helix | 485-495 | 11 | |
| α-helix | 498-500 | 3 | |
| α-helix | 503-508 | 6 | |
| α-helix | 511 | 1 | |
| β-strand | 512 | 1 | 15 |
| α-helix | 513 | 1 | |
| β-strand | 519 | 1 | 15 |
| α-helix | 520-534 | 15 | |
| α-helix | 538-540 | 3 | |
| α-helix | 553-559 | 7 | |
| α-helix | 565-568 | 4 | |
| β-strand | 581 | 1 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | A | protein | 576 | Homo sapiens | P23219 (AlphaFold model) |
>6Y3C_1 Prostaglandin G/H synthase 1 (chains A) ADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRP SPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSN VSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQH FTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPP SVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWG DEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHL YHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHI LHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFY PGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATL KKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
| ID | Name | Formula | Copies |
|---|---|---|---|
| FLC | Citrate anion | C6 H5 O7 | 3 |
Three-dimensional structure of human cyclooxygenase (hCOX)-1. Miciaccia, M., Belviso, B.D., Iaselli, M. et al. Sci Rep (2021) 11:4312-4312. DOI 10.1038/s41598-021-83438-z · PubMed
MolViewer shows 6Y3C directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.