6Z90: MINDY1 mutant-P138A

Crystal structure of MINDY1 mutant-P138A. Determined by X-ray diffraction at 3.59 Å resolution. Released 30 Jun 2021.

Method: X-ray diffraction
Resolution: 3.59 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,946
Mol. weight: 32.01 kDa
Released: 30 Jun 2021

Explore 6Z90 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6Z90 contains 9 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	113-121	9	1
β-strand	124-130	7	1
β-strand	131	1	2
α-helix	138-148	11
β-strand	160-162	3	1
α-helix	163-174	12
α-helix	189-200	12
α-helix	202-205	4
β-strand	212	1	3
β-strand	213	1	4
β-strand	220	1	3
α-helix	226-232	7
β-strand	236-238	3	5
β-strand	239	1	6
α-helix	247-253	7
β-strand	257	1	4
α-helix	260-268	9
α-helix	274-288	15
β-strand	294	1	6
α-helix	296-305	10
β-strand	312-316	5	5
β-strand	319-325	7	5
β-strand	330-333	4	5
β-strand	336	1	2
β-strand	347-349	3	5
β-strand	360	1	5
β-strand	366	1	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin carboxyl-terminal hydrolase MINDY-1	A	protein	289	Homo sapiens	Q8N5J2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6Z90_1 Ubiquitin carboxyl-terminal hydrolase MINDY-1 (chains A)
GPLGSPEFPGRLEMEPDFYCVKWIPWKGEQTPIITQSTNGPCALLAIMNILFLQWKVKLP
PQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFT
GVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTN
LVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVT
DQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPE

Primary citation

Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Abdul Rehman, S.A., Armstrong, L.A., Lange, S.M. et al. Mol Cell (2021) 81:4176-4190.e6. DOI 10.1016/j.molcel.2021.08.024 · PubMed

Other PDB entries of the same protein (UniProt Q8N5J2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5MN9 2.05 Å, Crystal structure of MINDY-1 tMIU in complex with K48-diUb
6TUV 2.16 Å, Crystal structure of Mindy1 in complex with Lys48 linked di-ubiquitin
6TXB 2.18 Å, Crystal structure of Mindy1 mutant (P138A) in complex with Lys48 linked di-ubiquitin
5JQS 2.65 Å, Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin
5JKN 3.0 Å, Crystal structure of deubiquitinase MINDY-1
6YJG 3.28 Å, Crystal structure of MINDY1 mutant-Y114F
6Y6R 3.32 Å, Crystal structure of MINDY1 T335D mutant

Browse structure collections

About this viewer

MolViewer shows 6Z90 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.