7AEA: Human RNA Polymerase III elongation complex 2

Cryo-EM structure of human RNA Polymerase III elongation complex 2. Determined by electron microscopy at 3.4 Å resolution. Released 3 Feb 2021.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Homo sapiens, synthetic construct
Chains: 20
Atoms: 42,422
Mol. weight: 743.6 kDa
Ligands: ZN, SF4, MG
Released: 3 Feb 2021

Explore 7AEA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7AEA contains 238 α-helices and 297 β-strands across 17 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 66 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	1
β-strand	12	1	2
β-strand	14-19	6	3
α-helix	28-31	4
β-strand	34-35	2	4
β-strand	38	1	5
α-helix	49-51	3
β-strand	54	1	5
β-strand	84-93	10	4
α-helix	98-105	8
β-strand	108	1	6
β-strand	115	1	6
α-helix	119-128	10
α-helix	137-150	14
β-strand	155	1	7
β-strand	162	1	7
β-strand	166-168	3	8
β-strand	174-176	3	8
α-helix	185-187	3
α-helix	188-195	8
α-helix	198-203	6
α-helix	207-210	4
β-strand	218	1	8
α-helix	220-227	8
α-helix	236-238	3
α-helix	247-249	3
β-strand	251-257	7	4
α-helix	278-298	21
α-helix	303-321	19
α-helix	351	1
α-helix	352-356	5
β-strand	360	1	9
β-strand	364-368	5	10
β-strand	369-371	3	11
β-strand	379-380	2	10
β-strand	381	1	11
β-strand	383	1	12
α-helix	384-387	4
β-strand	391-395	5	13
α-helix	401-410	10
β-strand	418-422	5	13
β-strand	430-431	2	13
α-helix	437-440	4
β-strand	449-453	5	13
α-helix	454	1
β-strand	459-463	5	10
α-helix	470-472	3
β-strand	473-478	6	10
β-strand	481	1	12
β-strand	486-488	3	11
α-helix	490-492	3
α-helix	493-496	4
β-strand	504-508	5	10
α-helix	513-520	8
β-strand	524	1	10
β-strand	530	1	14
β-strand	537	1	14
β-strand	541	1	15
α-helix	547-552	6
β-strand	558-559	2	16
α-helix	561-568	8
α-helix	569-571	3
α-helix	583-586	4
β-strand	588	1	17
β-strand	592	1	18
β-strand	594	1	17
β-strand	595-596	2	16
α-helix	597-605	9
β-strand	616-620	5	19
β-strand	637-641	5	19
β-strand	645-647	3	19
α-helix	652-655	4
β-strand	656	1	15
α-helix	663-670	8
α-helix	673-694	22
β-strand	697	1	20
α-helix	700-702	3
α-helix	712-732	21
α-helix	738-739	2
α-helix	744-764	21
α-helix	771-772	2
α-helix	776-782	7
α-helix	789-795	7
β-strand	801	1	21
β-strand	804	1	22
β-strand	807	1	22
α-helix	829-831	3
β-strand	833	1	21
α-helix	844-863	20
α-helix	865-879	15
β-strand	883-884	2	23
β-strand	890-891	2	23
β-strand	897-899	3	23
α-helix	902-904	3
β-strand	907	1	24
α-helix	909-911	3
α-helix	921-931	11
α-helix	938-940	3
α-helix	942-952	11
α-helix	957-960	4
α-helix	963-986	24
α-helix	998-1002	5
α-helix	1008-1023	16
β-strand	1026	1	24
α-helix	1033-1047	15
α-helix	1067-1075	9
β-strand	1085-1089	5	25
α-helix	1095-1105	11
β-strand	1108-1109	2	26
α-helix	1110-1112	3
β-strand	1114-1121	8	27
β-strand	1126-1132	7	27
α-helix	1134-1140	7
α-helix	1146-1152	7
α-helix	1162-1164	3
β-strand	1165-1166	2	27
β-strand	1172-1175	4	27
α-helix	1189-1195	7
α-helix	1196-1198	3
β-strand	1200-1202	3	26
β-strand	1209-1214	6	25
β-strand	1223-1228	6	25
α-helix	1232-1235	4
β-strand	1241-1242	2	25
α-helix	1243-1245	3
α-helix	1251-1257	7
α-helix	1260-1276	17
α-helix	1284-1294	11
β-strand	1297	1	28
α-helix	1308-1311	4
α-helix	1315-1319	5
α-helix	1324-1333	10
β-strand	1337-1339	3	3
α-helix	1344-1349	6
α-helix	1351-1353	3
α-helix	1356-1358	3
β-strand	1361-1364	4	1
α-helix	1375-1377	3

Chain B: 50 helices, 97 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
α-helix	25-28	4
α-helix	29-33	5
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-60	6
β-strand	64-66	3	29
β-strand	74-80	7	29
β-strand	86-88	3	30
β-strand	94-96	3	30
α-helix	99-104	6
β-strand	110-121	12	29
β-strand	123-127	5	29
β-strand	131-137	7	29
α-helix	138-139	2
β-strand	169-171	3	31
β-strand	174-178	5	31
α-helix	179	1
β-strand	180	1	32
β-strand	181-184	4	33
α-helix	185	1
β-strand	190-193	4	34
β-strand	199-204	6	34
β-strand	213-216	4	34
β-strand	217	1	35
β-strand	224-225	2	35
β-strand	230	1	36
α-helix	233	1
β-strand	234-235	2	35
α-helix	236-242	7
α-helix	248-255	8
α-helix	259-272	14
α-helix	280-288	9
β-strand	291	1	36
α-helix	292-293	2
α-helix	307-315	9
α-helix	329-347	19
α-helix	351-353	3
β-strand	360-363	4	33
α-helix	365-391	27
α-helix	402-405	4
α-helix	408-410	3
α-helix	412-421	10
β-strand	423	1	37
β-strand	426	1	38
β-strand	431	1	38
β-strand	434	1	37
β-strand	437-439	3	31
α-helix	440-441	2
α-helix	445-451	7
β-strand	454-456	3	32
α-helix	473-475	3
β-strand	479	1	39
β-strand	490	1	32
β-strand	493-495	3	32
β-strand	496	1	39
β-strand	501-502	2	40
α-helix	509-515	7
β-strand	521	1	41
α-helix	528-532	5
β-strand	537-541	5	41
β-strand	544-549	6	41
α-helix	552-564	13
β-strand	573-574	2	41
β-strand	577	1	41
β-strand	582-586	5	41
β-strand	592-598	7	40
β-strand	599	1	42
β-strand	604	1	42
α-helix	608-616	9
α-helix	621-626	6
β-strand	630-634	5	40
α-helix	637-639	3
β-strand	643-644	2	40
α-helix	647-649	3
β-strand	656-657	2	40
α-helix	661-663	3
α-helix	668-670	3
α-helix	680-689	10
β-strand	693	1	43
β-strand	695	1	44
β-strand	708-712	5	44
β-strand	716	1	45
β-strand	721	1	46
α-helix	723-727	5
α-helix	730-732	3
β-strand	737-741	5	47
β-strand	743	1	48
β-strand	744	1	20
β-strand	755-758	4	49
α-helix	759-762	4
β-strand	769-773	5	44
β-strand	774-779	6	50
β-strand	781	1	51
β-strand	787	1	51
β-strand	789-790	2	52
β-strand	795	1	53
β-strand	802	1	53
α-helix	804-806	3
β-strand	809	1	54
β-strand	814	1	55
β-strand	815	1	54
α-helix	816	1
β-strand	821	1	56
β-strand	826-828	3	55
β-strand	830-833	4	52
β-strand	851-853	3	52
β-strand	856-857	2	55
β-strand	864	1	56
β-strand	865-873	9	50
β-strand	879-886	8	50
β-strand	887-889	3	44
β-strand	896-897	2	57
β-strand	905-906	2	57
β-strand	907-911	5	49
β-strand	918	1	58
β-strand	928	1	49
β-strand	929	1	48
α-helix	941-953	13
β-strand	960	1	46
α-helix	973-978	6
β-strand	986-987	2	59
β-strand	990	1	58
β-strand	997	1	58
β-strand	1002-1003	2	59
β-strand	1005-1009	5	47
β-strand	1011	1	57
β-strand	1012	1	43
β-strand	1021-1023	3	10
β-strand	1028	1	60
β-strand	1035	1	60
α-helix	1039-1041	3
β-strand	1046	1	9
α-helix	1052-1057	6
α-helix	1062-1065	4
α-helix	1066-1070	5
α-helix	1071-1073	3
β-strand	1074-1080	7	2
β-strand	1086-1087	2	2
β-strand	1088	1	61
β-strand	1091	1	61
β-strand	1092	1	62
β-strand	1097	1	62
β-strand	1101-1107	7	2
α-helix	1108-1111	4
α-helix	1113-1119	7
β-strand	1125-1129	5	3

Chain C: 10 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	3-10	8
β-strand	13	1	63
β-strand	16	1	64
β-strand	21	1	64
β-strand	33	1	18
α-helix	42-48	7
β-strand	50-57	8	63
β-strand	60-66	7	63
α-helix	70-82	13
β-strand	86-94	9	65
α-helix	103-111	9
β-strand	115	1	66
α-helix	124-126	3
β-strand	140-142	3	65
β-strand	143-145	3	67
β-strand	147-148	2	68
α-helix	159-162	4
β-strand	163-164	2	68
β-strand	167-168	2	69
α-helix	170-172	3
β-strand	173-175	3	65
α-helix	181-184	4
β-strand	192	1	66
β-strand	200-201	2	69
β-strand	207-209	3	67
β-strand	212-217	6	65
β-strand	228-237	10	63
β-strand	240-241	2	70
β-strand	246	1	71
β-strand	262-266	5	71
β-strand	271-275	5	71
α-helix	278-280	3
β-strand	297-298	2	70
β-strand	301-312	12	63
α-helix	318-337	20

Chain D: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	1
β-strand	11	1	1
α-helix	15-26	12
α-helix	40-53	14
α-helix	63-72	10
α-helix	73-76	4
α-helix	80-88	9
α-helix	97-100	4
α-helix	104-107	4
α-helix	110-121	12

Chain E: 9 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-24	20
β-strand	26	1	72
α-helix	30-32	3
α-helix	37-40	4
β-strand	58	1	73
β-strand	62	1	74
β-strand	63	1	72
β-strand	71	1	74
β-strand	72-75	4	73
β-strand	81-82	2	75
α-helix	84-97	14
β-strand	101-106	6	73
β-strand	109-110	2	75
α-helix	112-119	8
β-strand	126-131	6	73
β-strand	147-150	4	28
α-helix	151-152	2
α-helix	153-162	10
α-helix	167-169	3
β-strand	172-173	2	28
α-helix	178-183	6
β-strand	190-196	7	28
β-strand	202-209	8	28

Chain F: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	76
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-98	10
β-strand	104-109	6	1
β-strand	115-119	5	1
β-strand	124	1	76

Chain G: 4 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	1
α-helix	15-17	3
α-helix	23-34	12
β-strand	37-39	3	1
β-strand	43-59	17	1
β-strand	66-77	12	1
α-helix	79-80	2
β-strand	84-93	10	77
β-strand	96-101	6	77
β-strand	104-109	6	77
α-helix	111-113	3
β-strand	128-129	2	78
β-strand	139-140	2	78
β-strand	148-157	10	77
β-strand	184-189	6	77
β-strand	196-197	2	77

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	79
β-strand	25-32	8	79
β-strand	38-44	7	79
β-strand	55-61	7	79
α-helix	84-87	4
β-strand	90-101	12	79
β-strand	111-117	7	79
β-strand	122-128	7	79
β-strand	139-147	9	79

9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1390	Homo sapiens	O14802 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1133	Homo sapiens	Q9NW08 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC9	D	protein	148	Homo sapiens	O75575 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase III subunit RPC8	G	protein	204	Homo sapiens	Q9Y535
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase III subunit RPC10	I	protein	108	Homo sapiens	Q9Y2Y1
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7AEA_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM
GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE
EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK
TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM
NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG
AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR
VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF
IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV
KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA
AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI
FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK
NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG
YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM
ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS
GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF
IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC
CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD
KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI
STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL
RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV
VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI
EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD
TNEFHIPLVT

Sequence of entity 2 (B), FASTA

>7AEA_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
ANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYT
RGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILI
QEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIF
KAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG
PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNK
RLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAIS
TGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLC
PSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVF
LNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK
KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIE
PFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMV
KTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLK
RYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPL
EGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSR
HGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHY
GTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKM
HARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVC
GQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE

Sequence of entity 3 (C), FASTA

>7AEA_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (D), FASTA

>7AEA_4 DNA-directed RNA polymerase III subunit RPC9 (chains D)
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRH
QSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTV
TSILPAEPEAEQKKNTNSNVAMDEEDPA

Sequence of entity 5 (E), FASTA

>7AEA_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>7AEA_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>7AEA_7 DNA-directed RNA polymerase III subunit RPC8 (chains G)
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

Sequence of entity 8 (H), FASTA

>7AEA_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>7AEA_9 DNA-directed RNA polymerase III subunit RPC10 (chains I)
MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Sequence of entity 10 (J), FASTA

>7AEA_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>7AEA_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 12 (L), FASTA

>7AEA_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7
SF4	Iron/sulfur cluster	Fe4 S4	1
MG	Magnesium ion	Mg	1

Primary citation

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Girbig, M., Misiaszek, A.D., Vorlander, M.K. et al. Nat Struct Mol Biol (2021) 28:210-219. DOI 10.1038/s41594-020-00555-5 · PubMed

Other PDB entries of the same protein (UniProt O14802 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AE1 2.8 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 1
9K39 2.8 Å, Human RNA Polymerase III de novo transcribing complex 8 (TC8)
7D58 2.9 Å, cryo-EM structure of human RNA polymerase III in elongating state
9K36 2.9 Å, Human RNA Polymerase III de novo transcribing complex 12 (TC12)
9K2G 3.0 Å, Human RNA Polymerase III de novo transcribing complex 13 (TC13)
9K3U 3.0 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)
7AE3 3.1 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 3
7D59 3.1 Å, cryo-EM structure of human RNA polymerase III in apo state
9K38 3.1 Å, Human RNA Polymerase III de novo transcribing complex 6 (TC6)
9FSO 3.28 Å, Human RNA Polymerase III Class III Open Pre-initiation Complex 1 (OC1)
7A6H 3.3 Å, Cryo-EM structure of human apo RNA Polymerase III
9LXN 3.3 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)(without 3'dATP)

Browse structure collections

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