The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein. Determined by X-ray diffraction at 1.8 Å resolution. Released 20 Apr 2022.
Explore 7AL7 in 3D Show helices and sheets RCSB PDB PDBe
7AL7 contains 10 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 66-70 | 5 | 1 |
| α-helix | 75-77 | 3 | |
| β-strand | 82-90 | 9 | 1 |
| β-strand | 97-102 | 6 | 2 |
| β-strand | 105-106 | 2 | 2 |
| α-helix | 107-109 | 3 | |
| β-strand | 114-116 | 3 | 1 |
| β-strand | 120-123 | 4 | 1 |
| β-strand | 128-136 | 9 | 1 |
| α-helix | 141-144 | 4 | |
| β-strand | 147-153 | 7 | 2 |
| β-strand | 158-164 | 7 | 2 |
| α-helix | 165-169 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 38-49 | 12 | 3 |
| α-helix | 54 | 1 | |
| β-strand | 55-58 | 4 | 3 |
| β-strand | 64-67 | 4 | 3 |
| α-helix | 74-76 | 3 | |
| α-helix | 79-81 | 3 | |
| β-strand | 83-90 | 8 | 3 |
| β-strand | 96-103 | 8 | 3 |
| β-strand | 107-111 | 5 | 3 |
| α-helix | 113-115 | 3 | |
| β-strand | 118-121 | 4 | 3 |
| α-helix | 123-125 | 3 | |
| β-strand | 127-128 | 2 | 3 |
| β-strand | 137-141 | 5 | 3 |
| β-strand | 149-153 | 5 | 3 |
| β-strand | 159-166 | 8 | 3 |
| β-strand | 169-176 | 8 | 3 |
| α-helix | 183-185 | 3 | |
| β-strand | 187-191 | 5 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Interleukin-18-binding protein | A | protein | 172 | Homo sapiens | O95998 (AlphaFold model) |
| Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18 | B | protein | 390 | Schistosoma japonicum, Homo sapiens | P08515 (AlphaFold model), Q14116 (AlphaFold model) |
>7AL7_1 Interleukin-18-binding protein (chains A) TGQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTS RERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQ EALPSSHSSPQQQGGTSDEVDGGSGGSGLNDIFEAQKIEWHEGRTKHHHHHH
>7AL7_2 Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18 (chains B) MHHHHHHSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPN LPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKD FETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFP KLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDREFDEVDYFGKLES KLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVK CEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLAC EKERDLFKLILKKEDELGDRSIMFTVQNED
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 3 |
Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. Detry, S., Andries, J., Bloch, Y. et al. J Biol Chem (2022) 298:101908-101908. DOI 10.1016/j.jbc.2022.101908 · PubMed
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