7ALO: B*27:09/photoRL9

Structure of B*27:09/photoRL9. Determined by X-ray diffraction at 1.8 Å resolution. Released 16 Jun 2021.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 6
Atoms: 7,344
Mol. weight: 96.25 kDa
Released: 16 Jun 2021

Explore 7ALO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ALO contains 27 α-helices and 60 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-14	12	1
β-strand	18-28	11	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	225-227	3
β-strand	229-230	2	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chains B and E: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chains C and F: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3

Chain D: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-14	12	8
β-strand	18-28	11	8
β-strand	31-37	7	8
β-strand	46-47	2	8
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	8
β-strand	109-118	10	8
β-strand	121-126	6	8
β-strand	133-135	3	8
α-helix	138-149	12
α-helix	152-159	8
α-helix	160-164	5
α-helix	165-174	10
α-helix	176-179	4
β-strand	183	1	9
α-helix	184-185	2
β-strand	186-193	8	10
β-strand	198-208	11	10
β-strand	209	1	9
β-strand	214-219	6	11
β-strand	222-223	2	11
α-helix	225-227	3
β-strand	229-230	2	10
α-helix	231-233	3
β-strand	234-235	2	10
β-strand	241-250	10	10
α-helix	254-256	3
β-strand	257-262	6	11
β-strand	270-272	3	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Lymphocyte antigen HLA-B27	A, D	protein	292	Homo sapiens	A0A2R7Z5J3 (AlphaFold model)
Beta-2-microglobulin	B, E	protein	100	Homo sapiens	P61769 (AlphaFold model)
Vasoactive intestinal polypeptide receptor 1	C, F	protein	9	Homo sapiens	P32241 (AlphaFold model)

Sequence of entity 1 (A, D), FASTA

>7ALO_1 Lymphocyte antigen HLA-B27 (chains A, D)
MAHHHHHHVDDDDKIGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPRE
EPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGP
DGRLLRGYHQHAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECV
EWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQT
QDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPS

Sequence of entity 2 (B, E), FASTA

>7ALO_2 Beta-2-microglobulin (chains B, E)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, F), FASTA

>7ALO_3 Vasoactive intestinal polypeptide receptor 1 (chains C, F)
RRKWRRWXL

Primary citation

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules. Lan, H., Abualrous, E.T., Sticht, J. et al. Nat Commun (2021) 12:4236-4236. DOI 10.1038/s41467-021-24401-4 · PubMed

Other PDB entries of the same protein (UniProt A0A2R7Z5J3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Y29 1.28 Å, Crystal structure of HLA-B2709 complexed with the nona-peptide mE
6Y2B 1.37 Å, Crystal structure of HLA-B2709 complexed with the nona-peptide mQ
6Y27 1.38 Å, Crystal structure of HLA-B2709 complexed with the nona-peptide mA

Browse structure collections

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