7AQK: Actin-related protein 2, Arp2

Model of the actin filament Arp2/3 complex branch junction in cells. Determined by electron microscopy at 9.0 Å resolution. Released 2 Dec 2020.

Method: Electron microscopy
Resolution: 9.0 Å
Organism: Mus musculus
Chains: 18
Atoms: 24,018
Mol. weight: 687.3 kDa
Released: 2 Dec 2020

Explore 7AQK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7AQK contains 344 α-helices and 311 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 25 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	7-9	3	6
β-strand	10-11	2	7
β-strand	16-19	4	7
β-strand	29-32	4	7
β-strand	35-38	4	8
β-strand	44	1	9
α-helix	53	1
α-helix	55	1
β-strand	60-62	3	8
α-helix	64-68	5
β-strand	72-75	4	8
β-strand	80	1	10
β-strand	82	1	10
α-helix	86-95	10
α-helix	96-101	6
β-strand	109-114	6	6
α-helix	121-128	8
α-helix	129-133	5
β-strand	138-143	6	6
α-helix	145-152	8
β-strand	164	1	11
β-strand	166-170	5	12
β-strand	175-178	4	12
β-strand	181	1	11
β-strand	184	1	11
β-strand	191	1	12
α-helix	197-211	15
α-helix	219-228	10
α-helix	238-247	10
β-strand	255-260	6	13
β-strand	265-270	6	13
α-helix	274-277	4
α-helix	280-282	3
α-helix	285-287	3
α-helix	296-304	9
α-helix	309-311	3
α-helix	312-317	6
β-strand	319-322	4	12
α-helix	324-326	3
α-helix	331-347	17
α-helix	348-350	3
α-helix	351-354	4
α-helix	371-373	3
α-helix	376-386	11
α-helix	388-390	3
β-strand	395-396	2	6
α-helix	397-401	5

Chain b: 19 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	1
β-strand	17-22	6	1
β-strand	30-33	4	1
β-strand	36-39	4	2
β-strand	56-57	2	2
α-helix	58-60	3
α-helix	62-67	6
β-strand	68-70	3	2
β-strand	74-75	2	3
β-strand	78-79	2	3
α-helix	84-92	9
β-strand	106-111	6	1
α-helix	118-127	10
β-strand	135-140	6	1
α-helix	143-147	5
β-strand	154-158	5	4
β-strand	164-170	7	4
β-strand	173-174	2	4
β-strand	180-182	3	4
α-helix	186-199	14
α-helix	206-209	4
α-helix	212-219	8
α-helix	227-237	11
β-strand	242-245	4	5
β-strand	251-254	4	5
α-helix	257-260	4
α-helix	263-266	4
α-helix	268-271	4
α-helix	277-288	12
α-helix	291-296	6
β-strand	302-304	3	4
α-helix	306-308	3
α-helix	313-328	16
α-helix	348-351	4
α-helix	353-365	13
β-strand	373	1	1
α-helix	375-379	5

Chain c: 5 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	14
β-strand	13-15	3	15
β-strand	22-23	2	16
β-strand	24-26	3	15
β-strand	32-38	7	16
β-strand	41-48	8	16
β-strand	58-61	4	17
β-strand	66-69	4	17
β-strand	77	1	18
β-strand	78-81	4	17
β-strand	86-87	2	17
β-strand	90	1	18
β-strand	99-104	6	19
β-strand	111-115	5	19
β-strand	121-126	6	19
β-strand	131-136	6	19
β-strand	145-151	7	20
β-strand	156-161	6	20
β-strand	166-170	5	20
β-strand	193-198	6	20
β-strand	205-210	6	21
β-strand	216-221	6	21
β-strand	225-230	6	21
β-strand	236-241	6	21
α-helix	246	1
β-strand	247-252	6	22
β-strand	257-262	6	22
β-strand	267-271	5	22
β-strand	280-284	5	22
α-helix	297-302	6
α-helix	314-318	5
β-strand	329-336	8	14
α-helix	338-341	4
β-strand	344-349	6	14
β-strand	354-357	4	14
α-helix	360-362	3

Chain d: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	9-24	16
β-strand	32-35	4	23
α-helix	38-40	3
β-strand	43-46	4	23
β-strand	54-59	6	23
α-helix	64-67	4
α-helix	73-79	7
α-helix	87-88	2
β-strand	93-98	6	23
α-helix	108-133	26
β-strand	142-144	3	24
β-strand	150-157	8	24
β-strand	160-167	8	24
β-strand	168	1	25
α-helix	172-181	10
α-helix	182-184	3
β-strand	197-199	3	24
β-strand	220	1	25
β-strand	224-227	4	24
α-helix	229-232	4
α-helix	236-244	9
α-helix	247-261	15
α-helix	263-276	14
α-helix	277-280	4

Chain e: 12 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	14-16	3	26
β-strand	19-21	3	26
α-helix	41-45	5
α-helix	49-52	4
α-helix	63-82	20
α-helix	88-90	3
α-helix	91-97	7
α-helix	102-104	3
α-helix	113-115	3
α-helix	118-119	2
α-helix	124-148	25
α-helix	158-161	4
α-helix	162-165	4
α-helix	168-170	3

Chain f: 6 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	5-18	14
α-helix	48-49	2
β-strand	50-54	5	27
β-strand	60-65	6	27
β-strand	69-75	7	27
α-helix	81-98	18
β-strand	104	1	27
β-strand	115-119	5	27
α-helix	121-125	5
α-helix	130-157	28
α-helix	160-164	5

Chain g: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	39-47	9
α-helix	51-58	8
α-helix	69-85	17
α-helix	88-97	10
α-helix	100-114	15
α-helix	121-136	16
α-helix	139-146	8

Chain h: 25 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	10-11	2	28
β-strand	16-19	4	28
β-strand	29-32	4	28
β-strand	35-37	3	29
β-strand	53-54	2	29
α-helix	55-59	5
α-helix	62-64	3
β-strand	66-67	2	29
β-strand	72	1	30
β-strand	76	1	30
α-helix	82-88	7
α-helix	89-94	6
α-helix	98-100	3
β-strand	102-104	3	31
β-strand	107	1	32
α-helix	113-120	8
α-helix	121-126	6
β-strand	131-133	3	31
β-strand	136	1	32
α-helix	138-145	8
β-strand	149-151	3	33
β-strand	154-155	2	34
β-strand	160-161	2	34
β-strand	164-166	3	33
β-strand	170	1	33
β-strand	178	1	34
α-helix	182-190	9
α-helix	203-215	13
α-helix	223-230	8
β-strand	240-241	2	35
β-strand	247-248	2	35
α-helix	257-259	3
α-helix	264-267	4
α-helix	272-273	2
α-helix	274-284	11
α-helix	292-295	4
β-strand	297-298	2	36
α-helix	302-305	4
α-helix	309-320	12
α-helix	321-322	2
β-strand	329-330	2	36
α-helix	335-337	3
α-helix	338-346	9
α-helix	350-354	5
α-helix	356	1
β-strand	357-358	2	31
α-helix	361-364	4
β-strand	365	1	37
β-strand	367	1	37
α-helix	370-372	3

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Actin-related protein 2, Arp2	b	protein	394	Mus musculus	P61161 (AlphaFold model)
Actin-related protein 3, Arp3	a	protein	418	Mus musculus	Q99JY9 (AlphaFold model)
Actin-related protein 2/3 complex subunit 1b, ArpC1b	c	protein	372	Mus musculus	Q9WV32 (AlphaFold model)
Actin-related protein 2/3 complex subunit 2, ArpC2	d	protein	300	Mus musculus	Q9CVB6 (AlphaFold model)
Actin-related protein 2/3 complex subunit 3, ArpC3	e	protein	178	Mus musculus	Q9JM76
Actin-related protein 2/3 complex subunit 4, ArpC4	f	protein	168	Mus musculus	P59999
Actin-related protein 2/3 complex subunit 5, ArpC5	g	protein	151	Mus musculus	Q9CPW4
Actin, alpha skeletal muscle, ACTA1	h, i, j, k, l, m, n, o, p, q, r	protein	377	Mus musculus	P68134

Sequence of entity 1 (b), FASTA

>7AQK_1 Actin-related protein 2, Arp2 (chains b)
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE
ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR
EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR
RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL
VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH
IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV
LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR

Sequence of entity 2 (a), FASTA

>7AQK_2 Actin-related protein 3, Arp3 (chains a)
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDF
FIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTP
ENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPV
AEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVK
EFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVV
DEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKP
KPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS

Sequence of entity 3 (c), FASTA

>7AQK_3 Actin-related protein 2/3 complex subunit 1b, ArpC1b (chains c)
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDW
APDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVI
SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERP
APTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATL
ASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARE
RFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVR
SLESALKDLKIV

Sequence of entity 4 (d), FASTA

>7AQK_4 Actin-related protein 2/3 complex subunit 2, ArpC2 (chains d)
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSIS
LKFYKELQAHGADELLKRVYGSYLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNC
FASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKV
FMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNT
INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR

Sequence of entity 5 (e), FASTA

>7AQK_5 Actin-related protein 2/3 complex subunit 3, ArpC3 (chains e)
MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEI
KNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKP
ANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ

Sequence of entity 6 (f), FASTA

>7AQK_6 Actin-related protein 2/3 complex subunit 4, ArpC4 (chains f)
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEK
VLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITN
FHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF

Sequence of entity 7 (g), FASTA

>7AQK_7 Actin-related protein 2/3 complex subunit 5, ArpC5 (chains g)
MSKNTVSSARFRKVDVDEYDENKFVDEDDGGDGQAGPDEGEVDSCLRQGNMTAALQAALK
NPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDN
SSAVLLQWHEKALAAGGVGSIVRVLTARKTV

Sequence of entity 8 (h, i, j, k, l, m, n, o, p, q, r), FASTA

>7AQK_8 Actin, alpha skeletal muscle, ACTA1 (chains h, i, j, k, l, m, n, o, p, q, r)
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
MSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIT
KQEYDEAGPSIVHRKCF

Primary citation

Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Fassler, F., Dimchev, G., Hodirnau, V.V. et al. Nat Commun (2020) 11:6437-6437. DOI 10.1038/s41467-020-20286-x · PubMed

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