7BQ0: Peroxisome proliferator-activated receptor alpha

X-ray structure of human PPARalpha ligand binding domain-fenofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization. Determined by X-ray diffraction at 1.77 Å resolution. Released 11 Nov 2020.

Method
X-ray diffraction
Resolution
1.77 Å
Organism
Homo sapiens
Chains
4
Atoms
4,839
Mol. weight
66.68 kDa
Ligands
F5A
Released
11 Nov 2020

Explore 7BQ0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7BQ0 contains 34 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix201-21717
α-helix222-2309
α-helix237-2382
β-strand239-24131
α-helix244-25310
α-helix255-2606
α-helix268-29225
α-helix302-32120
α-helix322-3243
β-strand325-32621
β-strand329-33241
β-strand337-34041
α-helix341-3455
α-helix3481
α-helix351-3533
α-helix356-36611
α-helix372-38312
α-helix394-41522
α-helix422-45029
α-helix458-4647
Chains B and D: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix688-6958
Chain C: 16 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix201-21717
α-helix222-2309
α-helix237-2382
β-strand239-24132
α-helix244-25310
α-helix255-2606
α-helix268-29225
α-helix302-32120
α-helix322-3243
β-strand325-32622
β-strand329-33242
β-strand337-34042
α-helix341-3466
α-helix3481
α-helix351-3533
α-helix356-36611
α-helix372-38312
α-helix394-41522
α-helix422-45029
α-helix458-4647

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Peroxisome proliferator-activated receptor alphaA, Cprotein273Homo sapiensQ07869 (AlphaFold model)
15-meric peptide from Nuclear receptor coactivator 1B, Dprotein15Homo sapiensQ15788 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>7BQ0_1 Peroxisome proliferator-activated receptor alpha (chains A, C)
GSHMTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLV
AKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYE
AIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDI
SLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQ
LVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Sequence of entity 2 (B, D), FASTA
>7BQ0_2 15-meric peptide from Nuclear receptor coactivator 1 (chains B, D)
LTERHKILHRLLQEG

Ligands and cofactors

IDNameFormulaCopies
F5A2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acidC17 H15 Cl O44

Primary citation

PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Kamata, S., Oyama, T., Saito, K. et al. iScience (2020) 23:101727-101727. DOI 10.1016/j.isci.2020.101727 · PubMed

Other PDB entries of the same protein (UniProt Q07869 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 7BQ0 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.