The mitochondrial SAM-Mdm10 supercomplex in GDN micelle from S.cere. Determined by electron microscopy at 2.8 Å resolution. Released 20 Jan 2021.
Explore 7BTX in 3D Show helices and sheets RCSB PDB PDBe
7BTX contains 46 α-helices and 70 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 126-129 | 4 | 1 |
| β-strand | 139-146 | 8 | 1 |
| β-strand | 156-166 | 11 | 1 |
| β-strand | 169-181 | 13 | 1 |
| β-strand | 184-196 | 13 | 1 |
| α-helix | 198-201 | 4 | |
| β-strand | 203-216 | 14 | 1 |
| β-strand | 235-251 | 17 | 1 |
| α-helix | 264-267 | 4 | |
| β-strand | 271-285 | 15 | 1 |
| β-strand | 296-306 | 11 | 1 |
| β-strand | 310-322 | 13 | 1 |
| β-strand | 330-342 | 13 | 1 |
| α-helix | 350-352 | 3 | |
| α-helix | 353-355 | 3 | |
| β-strand | 357 | 1 | 2 |
| β-strand | 359 | 1 | 3 |
| β-strand | 373 | 1 | 3 |
| β-strand | 376 | 1 | 4 |
| β-strand | 381 | 1 | 4 |
| β-strand | 384 | 1 | 2 |
| β-strand | 386-395 | 10 | 1 |
| β-strand | 408-420 | 13 | 1 |
| α-helix | 428-433 | 6 | |
| β-strand | 440-449 | 10 | 1 |
| β-strand | 454-466 | 13 | 1 |
| β-strand | 474-480 | 7 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 21-23 | 3 | 1 |
| α-helix | 31-40 | 10 | |
| β-strand | 41-42 | 2 | 5 |
| β-strand | 45 | 1 | 6 |
| β-strand | 60-64 | 5 | 5 |
| β-strand | 67-69 | 3 | 7 |
| β-strand | 75 | 1 | 8 |
| β-strand | 76-78 | 3 | 7 |
| α-helix | 81-94 | 14 | |
| β-strand | 97 | 1 | 6 |
| β-strand | 100 | 1 | 8 |
| β-strand | 115-117 | 3 | 5 |
| α-helix | 120-122 | 3 | |
| β-strand | 130-133 | 4 | 5 |
| β-strand | 139-141 | 3 | 5 |
| α-helix | 143-152 | 10 | |
| α-helix | 158-166 | 9 | |
| α-helix | 167-171 | 5 | |
| α-helix | 172-177 | 6 | |
| α-helix | 178-182 | 5 | |
| α-helix | 185-191 | 7 | |
| α-helix | 204-215 | 12 | |
| α-helix | 217-224 | 8 | |
| α-helix | 230-233 | 4 | |
| α-helix | 235-241 | 7 | |
| α-helix | 248-271 | 24 | |
| α-helix | 272-274 | 3 | |
| α-helix | 282-283 | 2 | |
| α-helix | 284-296 | 13 | |
| α-helix | 305-311 | 7 | |
| α-helix | 314-324 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-7 | 3 | 9 |
| β-strand | 11 | 1 | 10 |
| β-strand | 14 | 1 | 10 |
| α-helix | 20-30 | 11 | |
| α-helix | 35-38 | 4 | |
| β-strand | 46 | 1 | 11 |
| β-strand | 47 | 1 | 9 |
| α-helix | 52-54 | 3 | |
| β-strand | 62-65 | 4 | 9 |
| β-strand | 69-72 | 4 | 9 |
| α-helix | 74-83 | 10 | |
| α-helix | 105-107 | 3 | |
| α-helix | 108-117 | 10 | |
| α-helix | 118-122 | 5 | |
| α-helix | 123-131 | 9 | |
| α-helix | 134-136 | 3 | |
| α-helix | 137-141 | 5 | |
| α-helix | 157-168 | 12 | |
| α-helix | 187-193 | 7 | |
| α-helix | 205-240 | 36 | |
| α-helix | 250-262 | 13 | |
| α-helix | 268-278 | 11 | |
| α-helix | 281-295 | 15 | |
| β-strand | 304 | 1 | 11 |
| α-helix | 316-318 | 3 | |
| α-helix | 320-325 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-16 | 12 | |
| α-helix | 20-22 | 3 | |
| α-helix | 30-33 | 4 | |
| β-strand | 44-48 | 5 | 12 |
| β-strand | 55-62 | 8 | 12 |
| β-strand | 68-76 | 9 | 12 |
| α-helix | 81-83 | 3 | |
| β-strand | 140-147 | 8 | 12 |
| β-strand | 152-162 | 11 | 12 |
| β-strand | 165-174 | 10 | 12 |
| β-strand | 179-189 | 11 | 12 |
| β-strand | 194-199 | 6 | 12 |
| β-strand | 206 | 1 | 12 |
| β-strand | 209-211 | 3 | 12 |
| β-strand | 230-231 | 2 | 13 |
| β-strand | 234-240 | 7 | 12 |
| β-strand | 245-251 | 7 | 12 |
| β-strand | 252-258 | 7 | 13 |
| β-strand | 263-269 | 7 | 13 |
| β-strand | 280-284 | 5 | 13 |
| β-strand | 292-295 | 4 | 13 |
| β-strand | 296-297 | 2 | 14 |
| β-strand | 306-307 | 2 | 14 |
| β-strand | 313-316 | 4 | 15 |
| β-strand | 413-420 | 8 | 15 |
| β-strand | 426-434 | 9 | 15 |
| β-strand | 438 | 1 | 12 |
| β-strand | 439-447 | 9 | 15 |
| β-strand | 481 | 1 | 15 |
| β-strand | 486 | 1 | 15 |
| β-strand | 488 | 1 | 12 |
| β-strand | 491-492 | 2 | 12 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Mitochondrial outer membrane beta-barrel protein | A | protein | 363 | Saccharomyces cerevisiae | E9P977 (AlphaFold model) |
| Sorting assembly machinery 35 kDa subunit | B | protein | 329 | Saccharomyces cerevisiae | P14693 (AlphaFold model) |
| Sorting assembly machinery 37 kDa subunit | C | protein | 327 | Saccharomyces cerevisiae | P50110 (AlphaFold model) |
| MDM10 isoform 1 | L | protein | 493 | Saccharomyces cerevisiae | A0A6A5PXD8 |
>7BTX_1 Mitochondrial outer membrane beta-barrel protein (chains A) TFTAKTGTNFGNDNDAEAYLQFEKLIDKKYLKLPTRVNLEILRGTKIHSSFLFNSYSSLS PQSILNLKVFSQFYNWNTNKGLDIGQRGARLSLRYEPLFLHKLLHNPHSNESPTLFHEWF LETCWRSTKICSQGTSAPYMYSGTMLSQAGDQLRTILGHTFVLDKRDHIMCPTKGSMLKW SNELSPGKHLKTQLELNSVKSWMNDDFITFSTTIKTGYLKNLSSQQSLPVHICDKFQSGG PSDIRGFQTFGLGPRDLYDAVGGDAFVSYGLSVFSRLPWKKVEKSNFRLHWFFNGGKLVN HDNTSLGNCIGQLSKEHSTSTGIGLVLRHPMARFELNFTLPITAHENDLIRKGFQFGLGL AFL
>7BTX_2 Sorting assembly machinery 35 kDa subunit (chains B) MVSSFSVPMPVKRIFDTFPLQTYAAQTDKDEAVALEIQRRSYTFTERGGGSSELTVEGTY KLGVYNVFLEANTGAALATDPWCLFVQLALCQKNGLVLPTHSQEQTPSHTCNHEMLVLSR LSNPDEALPILVEGYKKRIIRSTVAISEIMRSRILDDAEQLMYYTLLDTVLYDCWITQII FCASDAQFMELYSCQKLSGSIVTPLDVENSLLQKLSAKSLKISLTKRNKFQFRHREIVKS MQGVYHNHHNSVNQEQVLNVLFENSKQVLLGLKDMLKSDGQPTYLHLKIASYILCITNVK EPIKLKTFVENECKELVQFAQDTLKNFVQ
>7BTX_3 Sorting assembly machinery 37 kDa subunit (chains C) MVKGSVHLWGKDGKASLISVDSIALVWFIKLCTSEEAKSMVAGLQIVFSNNTDLSSDGKL PVLILDNGTKVSGYVNIVQFLHKNICTSKYEKGTDYEEDLAIVRKKDRLLEYSLLNYVDV EISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEEIIGSLTLED DEEFVESKAMESASQLAQSKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAAR KKLDDSVILSSDLLFLANLYVQLGLPDGNRIRSKLEQTFGSELLNSMSNKIDDFVHRPSN NLEQRDPQFREQGNVVMSLYNLACKYI
>7BTX_4 MDM10 isoform 1 (chains L) MLPYMDQVLRAFYQSTHWSTQNSYEDITATSRTLLDFRIPSAIHLQISNKSTPNTFNSLD FSTRSRINGSLSYLYSDAQQLEKFMRNSTDIPLQDATETYRQLQPNLNFSVSSANTLSSD NTTVDNDKKLLHDSKFVKKSLYYGRMYYPSSDLEAMIIKRLSPQTQFMLKGVSSFKESLN VLTCYFQRDSHRNLQEWIFSTSDLLCGYRVLHNFLTTPSKFNTSLYNNSSLSLGAEFWLG LVSLSPGCSTTLRYYTHSTNTGRPLTLTLSWNPLFGHISSTYSAKTGTNSTFCAKYDFNL YSIESNLSFGCEFWQKKHHLLETNKNNNDKLEPISDELVDINPNSRATKLLHENVPDLNS AVNDIPSTLDIPVHKQKLLNDLTYAFSSSLRKIDEERSTIEKFDNKINSSIFTSVWKLST SLRDKTLKLLWEGKWRGFLISAGTELVFTRGFQESLSDDEKNDNAISISATDTENGNIPV FPAKFGIQFQYST
Mitochondrial sorting and assembly machinery operates by beta-barrel switching. Takeda, H., Tsutsumi, A., Nishizawa, T. et al. Nature (2021) 590:163-169. DOI 10.1038/s41586-020-03113-7 · PubMed
Other PDB entries of the same protein (UniProt E9P977 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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