7CEC: Alpha6beta1 integrin

Structure of alpha6beta1 integrin in complex with laminin-511. Determined by electron microscopy at 3.9 Å resolution. Released 23 Jun 2021.

Method: Electron microscopy
Resolution: 3.9 Å
Organisms: Homo sapiens, Mus musculus
Chains: 9
Atoms: 17,561
Mol. weight: 289.01 kDa
Ligands: CA, NAG, MN
Released: 23 Jun 2021

Explore 7CEC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CEC contains 56 α-helices and 178 β-strands across 9 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 53 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
β-strand	11-14	4	2
β-strand	24-30	7	3
β-strand	36-42	7	3
β-strand	47	1	4
α-helix	48-49	2
β-strand	56	1	4
β-strand	58	1	5
β-strand	61-63	3	3
β-strand	72-73	2	3
β-strand	85	1	6
β-strand	92	1	5
β-strand	96-98	3	7
β-strand	105-107	3	7
β-strand	113-116	4	6
β-strand	124-127	4	6
β-strand	132-134	3	7
α-helix	162-164	3
β-strand	172-173	2	8
β-strand	180-184	5	8
α-helix	187-190	4
β-strand	192	1	9
β-strand	193-197	5	8
β-strand	214-215	2	8
β-strand	235	1	9
β-strand	239-242	4	10
β-strand	252-257	6	10
α-helix	260-262	3
β-strand	265-271	7	10
β-strand	278-285	8	10
β-strand	297-300	4	11
β-strand	309-318	10	11
β-strand	325-331	7	11
α-helix	341-343	3
β-strand	344-347	4	11
β-strand	358	1	12
β-strand	362	1	12
β-strand	371-376	6	12
β-strand	383-388	6	12
β-strand	400-403	4	12
β-strand	409-417	9	2
β-strand	426-431	6	2
β-strand	435-438	4	2
β-strand	441	1	1
β-strand	445	1	13
β-strand	446-447	2	14
β-strand	452-453	2	15
β-strand	458	1	16
β-strand	473-480	8	15
β-strand	482-483	2	14
β-strand	493-501	9	17
β-strand	514-515	2	15
β-strand	525-531	7	17
β-strand	538-546	9	15
α-helix	556	1
β-strand	557-565	9	17
α-helix	582-583	2
β-strand	584	1	13
α-helix	585	1
β-strand	592-596	5	17
β-strand	598	1	16

Chain B: 21 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
α-helix	15-19	5
β-strand	25	1	18
β-strand	27	1	19
β-strand	46	1	18
α-helix	47-52	6
α-helix	57-59	3
β-strand	61	1	19
β-strand	67-71	5	20
α-helix	73-75	3
β-strand	94-95	2	21
β-strand	98-104	7	20
β-strand	108-111	4	21
β-strand	114-115	2	21
α-helix	117-119	3
β-strand	123-127	5	22
β-strand	130	1	22
α-helix	136-156	21
β-strand	161-167	7	22
α-helix	180-184	5
α-helix	194-196	3
β-strand	199-206	8	22
α-helix	209-215	7
α-helix	216-218	3
β-strand	229	1	23
α-helix	232-240	9
α-helix	242-245	4
β-strand	251-257	7	22
β-strand	262	1	23
α-helix	268-271	4
β-strand	284	1	22
β-strand	287	1	22
α-helix	290-292	3
α-helix	295-298	4
α-helix	299-309	11
β-strand	311-316	6	22
α-helix	322-331	10
β-strand	335-337	3	22
α-helix	345-354	10
β-strand	361-363	3	24
β-strand	364-366	3	20
β-strand	373-380	8	21
α-helix	382-384	3
β-strand	386-388	3	21
α-helix	390-393	4
β-strand	394-396	3	24
β-strand	404-412	9	21
β-strand	421-427	7	20
β-strand	434-441	8	20

Chain C: 15 helices, 48 β-strands

Element	Residues	Length	Sheet
α-helix	2707-2731	25
β-strand	2737-2740	4	25
β-strand	2745-2747	3	26
α-helix	2755-2757	3
β-strand	2760-2767	8	25
β-strand	2780-2786	7	26
β-strand	2794-2800	7	26
β-strand	2803-2809	7	26
β-strand	2816-2819	4	26
β-strand	2829-2835	7	25
β-strand	2839-2846	8	25
β-strand	2853-2859	7	25
α-helix	2860-2861	2
α-helix	2871-2873	3
β-strand	2875-2878	4	26
α-helix	2886-2888	3
β-strand	2897-2905	9	25
β-strand	2915-2918	4	26
α-helix	2927-2930	4
β-strand	2931	1	27
α-helix	2938-2941	4
β-strand	2944	1	28
β-strand	2954-2955	2	29
β-strand	2965-2970	6	28
β-strand	2978-2980	3	30
β-strand	2982	1	29
β-strand	2983	1	31
β-strand	2988-2990	3	31
β-strand	2991-2992	2	30
β-strand	2993-2994	2	32
β-strand	2997-2998	2	32
β-strand	3001-3003	3	31
β-strand	3009	1	31
α-helix	3011-3013	3
α-helix	3017-3018	2
β-strand	3019	1	32
β-strand	3026-3032	7	28
β-strand	3038-3043	6	28
β-strand	3046-3052	7	28
α-helix	3057-3059	3
β-strand	3062-3063	2	29
α-helix	3075-3080	6
β-strand	3091-3092	2	28
β-strand	3095-3096	2	33
β-strand	3099-3100	2	33
β-strand	3113	1	28
α-helix	3118-3120	3
β-strand	3124-3131	8	34
β-strand	3134-3136	3	35
β-strand	3147-3154	8	34
β-strand	3161-3167	7	35
β-strand	3170-3177	8	35
β-strand	3180-3185	6	35
β-strand	3188-3191	4	35
β-strand	3202-3208	7	34
β-strand	3213-3217	5	34
β-strand	3220-3223	4	34
α-helix	3225-3229	5
β-strand	3243-3246	4	35
α-helix	3256-3257	2
β-strand	3258-3267	10	34
α-helix	3276-3278	3
β-strand	3288-3289	2	34

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1741-1784	44

Chain E: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
α-helix	1567-1595	29
β-strand	1602	1	27

Chain F: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	36
β-strand	11-12	2	37
β-strand	17-19	3	36
β-strand	21-25	5	36
α-helix	29-31	3
β-strand	33-39	7	38
β-strand	45-51	7	38
β-strand	57-58	2	38
β-strand	67-72	6	36
β-strand	77-82A	7	36
α-helix	84-86	3
β-strand	88-95	8	38
β-strand	100C-103	4	38
β-strand	108-109	2	38
β-strand	110-111	2	37
α-helix	117-121	5
α-helix	125-163	39

Chain G: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	39
β-strand	10-12	3	40
β-strand	19-25	7	39
β-strand	33-38	6	40
β-strand	44-49	6	40
β-strand	53-54	2	40
β-strand	62-67	6	39
β-strand	70-75	6	39
α-helix	80-82	3
β-strand	84-90	7	40
α-helix	96	1
β-strand	97-98	2	40
β-strand	102-105	4	40
α-helix	112-115	4
α-helix	120-158	39

Chain H: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	10-12	3	41
β-strand	18-23	6	42
β-strand	32-38	7	43
β-strand	46-51	6	43
β-strand	57-59	3	43
β-strand	67-72	6	42
β-strand	77-82	6	42
α-helix	84-86	3
β-strand	88-90	3	41
β-strand	91-96	6	43
β-strand	100D	1	43
β-strand	107-111	5	41

1 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Integrin alpha-6	A	protein	627	Homo sapiens	P23229 (AlphaFold model)
Integrin beta-1	B	protein	454	Homo sapiens	P05556 (AlphaFold model)
Laminin subunit alpha-5	C	protein	674	Homo sapiens	O15230 (AlphaFold model)
Laminin subunit beta-1	D	protein	74	Homo sapiens	P07942 (AlphaFold model)
Laminin subunit gamma-1	E	protein	83	Homo sapiens	P11047
TS2/16 VH(S112C)-SARAH,TS2/16 VH(S112C)-sarah	F	protein	172	Mus musculus, Homo sapiens	Q13043
TS2/16 vl-SARAH(S37C),TS2/16 vl-SARAH(S37C)	G	protein	164	Mus musculus, Homo sapiens	Q13043
Huts-4 VH(S112C)-sarah,huts-4 VH(S112C)-sarah	H	protein	174	Mus musculus, Homo sapiens	Q13043
Huts-4 VL(C87Y)-SARAH(S37C),HUTS-4 VL(C87Y)-SARAH(S37C)	I	protein	159	Mus musculus, Homo sapiens	Q13043

Sequence of entity 1 (A), FASTA

>7CEC_1 Integrin alpha-6 (chains A)
FNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGL
YSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNT
KQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYI
VFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLD
SGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVV
DLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKN
IGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLD
RNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCF
EYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCM
EETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLK
EGCGDDNVCNSNLKLEYKGSLENLYFQ

Sequence of entity 2 (B), FASTA

>7CEC_2 Integrin beta-1 (chains B)
QTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDI
ENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAED
YPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP
AKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAV
CGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIA
HLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSS
EVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDS
DSFKIRPLGFTEEVEVILQYICECEGGLENLYFQ

Sequence of entity 3 (C), FASTA

>7CEC_3 Laminin subunit alpha-5 (chains C)
GENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALS
ASIGRVRELCAQARGAASKVKVPMKFNGRSGVQLRTPRDLADLAAYTALKFYLQGPEPEP
GQGTEDRFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDIGEQFAAVSL
DRTLQFGHMSVTVERQMIQETKGDTVAPGAEGLLNLRPDDFVFYVGGYPSTFTPPPLLRF
PGYRGCIEMDTLNEEVVSLYNFERTFQLDTAVDRPCARSKSTGDPWLTDGSYLDGTGFAR
ISFDSQISTTKRFEQELRLVSYSGVLFFLKQQSQFLCLAVQEGSLVLLYDFGAGLKKAVP
LQPPPPLTSASKAIQVFLLGGSRKRVLVRVERATVYSVEQDNDLELADAYYLGGVPPDQL
PPSLRRLFPTGGSVRGCVKGIKALGKYVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFL
RLALSNVAPLTGNVYSGFGFHSAQDSALLYYRASPDGLCQVSLQQGRVSLQLLRTEVKTQ
AGFADGAPHYVAFYSNATGVWLYVDDQLQQMKPHRGPPPELQPQPEGPPRLLLGGLPESG
TIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTGCAPALQAQTPGLGPRGLQATAR
KASRRSRQPARHPA

Sequence of entity 4 (D), FASTA

>7CEC_4 Laminin subunit beta-1 (chains D)
GDARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLL
KDISQKVAVYSTCL

Sequence of entity 5 (E), FASTA

>7CEC_5 Laminin subunit gamma-1 (chains E)
GDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKCI
RNLEDIRKTLPSGCFNTPSIEKP

Sequence of entity 6 (F), FASTA

>7CEC_6 TS2/16 VH(S112C)-SARAH,TS2/16 VH(S112C)-SARAH (chains F)
MDVKLVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVATISSGGSYTY
YPDSVKGRFTISRDKAKNTLYLQMGSLKSEDTAMYYCTRIGYDEDYAMDHWGQGTSVTVC
SGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK

Sequence of entity 7 (G), FASTA

>7CEC_7 TS2/16 VL-SARAH(S37C),TS2/16 VL-SARAH(S37C) (chains G)
GSHMQIVVTQRPTTMAASPGDKIIITCSVSSIISSNYLHWYSQKPGFSPKLLIYRTSNLA
SGVPPRFSGSGSGTSYSLTIGTMEAEDVATYYCQQGSDIPLTFGDGTKLDLKRGSDYEFL
KSWTVEDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAK

Sequence of entity 8 (H), FASTA

>7CEC_8 HUTS-4 VH(S112C)-SARAH,HUTS-4 VH(S112C)-SARAH (chains H)
MQVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVSWIRQPSGKGLEWLAHIYWDDDK
RYHPSLKSRLTISKDTSSNQVFLKITSVDTADTATYYCARSIYDGYYDYFDVWGAGTTVT
VCSGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK

Sequence of entity 9 (I), FASTA

>7CEC_9 HUTS-4 VL(C87Y)-SARAH(S37C),HUTS-4 VL(C87Y)-SARAH(S37C) (chains I)
MQIVLSQSPAILSASPGEKVTMTCRATSSVTYMHWYQQKPGSSPKPWIYATSNLASGVPA
RFSGSGSGTSYSLTISRVEAADAATYYCQQWTSNPPTFGGGTKLEIKRGSDYEFLKSWTV
EDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	6
MN	Manganese (II) ion	Mn	3

Primary citation

Structural mechanism of laminin recognition by integrin. Arimori, T., Miyazaki, N., Mihara, E. et al. Nat Commun (2021) 12:4012-4012. DOI 10.1038/s41467-021-24184-8 · PubMed

Other PDB entries of the same protein (UniProt P23229 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7CEB 2.89 Å, Crystal structure of alpha6beta1 integrin headpiece

Browse structure collections

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