7CUJ: Fission yeast Ccq1 and Tpz1

Crystal structure of fission yeast Ccq1 and Tpz1. Determined by X-ray diffraction at 2.4 Å resolution. Released 25 Aug 2021.

Method
X-ray diffraction
Resolution
2.4 Å
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Chains
4
Atoms
4,806
Mol. weight
81.67 kDa
Released
25 Aug 2021

Explore 7CUJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CUJ contains 38 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 7 β-strands

ElementResiduesLengthSheet
β-strand133-13861
α-helix139-1413
α-helix142-15413
α-helix156-1638
α-helix169-18719
α-helix189-1924
α-helix219-2213
α-helix224-23411
β-strand243-24861
α-helix251-26313
β-strand268-27031
β-strand284-28851
α-helix289-2913
α-helix292-2954
α-helix296-2994
β-strand306-31051
α-helix313-32210
α-helix324-3263
β-strand330-33561
α-helix339-3457
α-helix354-36512
α-helix397-41620
α-helix421-4233
α-helix427-4315
α-helix433-4353
β-strand43812
Chain B: 17 helices, 7 β-strands
ElementResiduesLengthSheet
β-strand133-13864
α-helix139-1413
α-helix142-15413
α-helix156-1649
α-helix169-18719
α-helix189-1924
α-helix224-23613
β-strand243-24864
α-helix251-26111
β-strand268-27034
β-strand284-28854
α-helix289-2913
α-helix292-2987
β-strand306-31054
α-helix313-32210
β-strand330-33564
α-helix339-3468
α-helix347-3493
α-helix354-36512
α-helix397-41620
α-helix421-4233
α-helix427-4315
α-helix433-4353
β-strand43813
Chain C: 1 helix, 1 β-strand
ElementResiduesLengthSheet
β-strand43113
α-helix441-46525
Chain D: 1 helix, 1 β-strand
ElementResiduesLengthSheet
β-strand43112
α-helix441-46121

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Coiled-coil quantitatively-enriched protein 1A, Bprotein317Schizosaccharomyces pombe (strain 972 / ATCC 24843)Q10432 (AlphaFold model)
Protection of telomeres protein tpz1C, Dprotein45Schizosaccharomyces pombe (strain 972 / ATCC 24843)O14246 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>7CUJ_1 Coiled-coil quantitatively-enriched protein 1 (chains A, B)
ITKSSKSSFSVLDIGLPMSALQRKMMHRLVQYFAFCIDHFCTGPSDSRIQEKIRLFIQSA
HNIAKHPSLYDTEVRNPSAAESTNSHVSLDASNFSSYAENSSKFLFLQELFKNLSPSYSK
TFFLFISNQFLANTLTQWLKSQNIDAELWAEEDAKTSQHPAIWICVSKKAPSASHFLQSC
PDLSATIFYDIEAYMSVTSSLPSIQSLVLRLIHLGSIEHAIKCFQSSYNASFLVNIVGVV
ATLSSSSEENSEASNLSTLFEKSGNFEEILGSESHSSITEKTRDIAKNVATWLKNGENFS
SWPLPPLMDLASLSVAE
Sequence of entity 2 (C, D), FASTA
>7CUJ_2 Protection of telomeres protein tpz1 (chains C, D)
QIELEYKRKPIPDYDFMKGLETTLQELYVEHQSKKRRLELFQLTN

Primary citation

Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. Sun, H., Wu, Z., Zhou, Y. et al. PLoS Genet (2022) 18:e1010308-e1010308. DOI 10.1371/journal.pgen.1010308 · PubMed

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