7EGC: P53-bound TFIID-based holo PIC on HDM2 promoter
p53-bound TFIID-based holo PIC on HDM2 promoter. Determined by electron microscopy at 3.9 Å resolution. Released 12 May 2021.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organisms
- Homo sapiens, Sus scrofa
- Chains
- 51
- Atoms
- 113,129
- Mol. weight
- 2592.32 kDa
- Ligands
- ZN, SF4, MG
- Released
- 12 May 2021
Explore 7EGC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7EGC contains 619 α-helices and 570 β-strands across 49 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 8 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-15 | 4 | |
| β-strand | 21-23 | 3 | 1 |
| β-strand | 31 | 1 | 1 |
| α-helix | 32-39 | 8 | |
| β-strand | 45 | 1 | 2 |
| β-strand | 52 | 1 | 2 |
| β-strand | 59-61 | 3 | 1 |
| α-helix | 66-79 | 14 | |
| α-helix | 92-111 | 20 | |
| α-helix | 114-129 | 16 | |
| α-helix | 132-170 | 39 | |
| α-helix | 268-272 | 5 | |
| α-helix | 289-301 | 13 | |
Chain 1: 19 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 111-119 | 9 | |
| α-helix | 122-128 | 7 | |
| α-helix | 129-133 | 5 | |
| α-helix | 139-144 | 6 | |
| α-helix | 191-199 | 9 | |
| α-helix | 201-210 | 10 | |
| α-helix | 217-222 | 6 | |
| α-helix | 241-252 | 12 | |
| α-helix | 253-257 | 5 | |
| α-helix | 269-274 | 6 | |
| α-helix | 296-317 | 22 | |
| α-helix | 349-357 | 9 | |
| α-helix | 361-364 | 4 | |
| α-helix | 380-383 | 4 | |
| α-helix | 398-410 | 13 | |
| α-helix | 420-434 | 15 | |
| α-helix | 455-478 | 24 | |
| α-helix | 486-514 | 29 | |
| α-helix | 523-545 | 23 | |
Chain 2: 15 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 55 | 1 | 8 |
| β-strand | 60 | 1 | 9 |
| β-strand | 61-66 | 6 | 10 |
| α-helix | 70-72 | 3 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103 | 1 | 9 |
| β-strand | 104-110 | 7 | 10 |
| β-strand | 113-121 | 9 | 10 |
| α-helix | 124-134 | 11 | |
| α-helix | 142-144 | 3 | |
| α-helix | 147-155 | 9 | |
| β-strand | 166-171 | 6 | 10 |
| α-helix | 182-191 | 10 | |
| β-strand | 195-200 | 6 | 10 |
| α-helix | 206-214 | 9 | |
| β-strand | 220-221 | 2 | 10 |
| α-helix | 225-234 | 10 | |
| α-helix | 238-239 | 2 | |
| β-strand | 240 | 1 | 8 |
| α-helix | 241 | 1 | |
| β-strand | 251 | 1 | 11 |
| β-strand | 252-253 | 2 | 12 |
| α-helix | 255-256 | 2 | |
| β-strand | 257-258 | 2 | 13 |
| β-strand | 270 | 1 | 14 |
| β-strand | 285 | 1 | 14 |
| β-strand | 288-289 | 2 | 13 |
| β-strand | 298 | 1 | 13 |
| β-strand | 311-312 | 2 | 12 |
| α-helix | 315-319 | 5 | |
| β-strand | 332-334 | 3 | 15 |
| β-strand | 344 | 1 | 16 |
| β-strand | 351 | 1 | 16 |
| β-strand | 357-359 | 3 | 15 |
| β-strand | 366-367 | 2 | 15 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain 3: 13 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-16 | 7 | 17 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 17 |
| β-strand | 67-69 | 3 | 17 |
| α-helix | 102-119 | 18 | |
| α-helix | 134-149 | 16 | |
| β-strand | 159-165 | 7 | 17 |
| α-helix | 168-170 | 3 | |
| α-helix | 171-173 | 3 | |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 17 |
| α-helix | 201-209 | 9 | |
| β-strand | 213-216 | 4 | 17 |
| α-helix | 220-222 | 3 | |
| α-helix | 224-226 | 3 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-238 | 4 | |
| β-strand | 241 | 1 | 18 |
| α-helix | 244-250 | 7 | |
| β-strand | 254 | 1 | 19 |
| β-strand | 261 | 1 | 19 |
| β-strand | 266-267 | 2 | 11 |
| β-strand | 274-275 | 2 | 11 |
| β-strand | 282 | 1 | 20 |
| β-strand | 287 | 1 | 20 |
Chain 4: 23 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-34 | 7 | |
| α-helix | 38-45 | 8 | |
| α-helix | 50-59 | 10 | |
| β-strand | 66 | 1 | 21 |
| α-helix | 68-72 | 5 | |
| β-strand | 75 | 1 | 18 |
| α-helix | 77-79 | 3 | |
| α-helix | 84-92 | 9 | |
| β-strand | 96-100 | 5 | 21 |
| β-strand | 106-110 | 5 | 21 |
| α-helix | 112-122 | 11 | |
| α-helix | 142-144 | 3 | |
| α-helix | 145-164 | 20 | |
| α-helix | 175-181 | 7 | |
| β-strand | 187 | 1 | 22 |
| β-strand | 194 | 1 | 22 |
| α-helix | 198-204 | 7 | |
| α-helix | 208-220 | 13 | |
| α-helix | 230-240 | 11 | |
| α-helix | 256-268 | 13 | |
| β-strand | 271-273 | 3 | 23 |
| β-strand | 281-283 | 3 | 23 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-310 | 4 | 24 |
| β-strand | 314-317 | 4 | 24 |
| α-helix | 322-331 | 10 | |
| β-strand | 333-337 | 5 | 24 |
| β-strand | 342-345 | 4 | 24 |
| α-helix | 348-357 | 10 | |
| α-helix | 363-370 | 8 | |
| α-helix | 374-376 | 3 | |
| α-helix | 386-399 | 14 | |
| β-strand | 407-409 | 3 | 25 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-435 | 5 | 25 |
| β-strand | 440-443 | 4 | 25 |
| α-helix | 445-447 | 3 | |
| α-helix | 448-461 | 14 | |
Chain 5: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-11 | 2 | 28 |
| α-helix | 14-16 | 3 | |
| α-helix | 17-24 | 8 | |
| β-strand | 37-39 | 3 | 28 |
| β-strand | 42-43 | 2 | 28 |
| α-helix | 50-59 | 10 | |
Chain 6: 30 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 76-78 | 3 | 33 |
| β-strand | 83-87 | 5 | 33 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 33 |
| β-strand | 113-117 | 5 | 33 |
| α-helix | 120-129 | 10 | |
| α-helix | 133-141 | 9 | |
| β-strand | 144 | 1 | 33 |
| α-helix | 150-160 | 11 | |
| β-strand | 166-171 | 6 | 34 |
| β-strand | 174-179 | 6 | 34 |
| α-helix | 182-189 | 8 | |
| α-helix | 192-197 | 6 | |
| β-strand | 268-272 | 5 | 34 |
| α-helix | 274-276 | 3 | |
| α-helix | 277-286 | 10 | |
| β-strand | 291-295 | 5 | 34 |
| α-helix | 318-327 | 10 | |
| β-strand | 337 | 1 | 35 |
| β-strand | 338 | 1 | 36 |
| β-strand | 339 | 1 | 35 |
| α-helix | 346-357 | 12 | |
| β-strand | 363-364 | 2 | 36 |
| α-helix | 370-379 | 10 | |
| α-helix | 384-386 | 3 | |
| α-helix | 400-403 | 4 | |
| β-strand | 407-408 | 2 | 36 |
| α-helix | 421-424 | 4 | |
| α-helix | 425-427 | 3 | |
| α-helix | 430-433 | 4 | |
| β-strand | 437-441 | 5 | 36 |
| α-helix | 451-457 | 7 | |
| β-strand | 462-466 | 5 | 36 |
| α-helix | 481-484 | 4 | |
| β-strand | 487-490 | 4 | 35 |
| α-helix | 493-497 | 5 | |
| β-strand | 506 | 1 | 37 |
| β-strand | 507-512 | 6 | 38 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-524 | 9 | |
| α-helix | 529-535 | 7 | |
| α-helix | 538-552 | 15 | |
| β-strand | 560-561 | 2 | 39 |
| α-helix | 567-573 | 7 | |
| β-strand | 579 | 1 | 39 |
| α-helix | 586-594 | 9 | |
| β-strand | 606-607 | 2 | 39 |
| β-strand | 623 | 1 | 38 |
| α-helix | 636-643 | 8 | |
| β-strand | 659-664 | 6 | 38 |
| α-helix | 670-673 | 4 | |
| α-helix | 675-680 | 6 | |
| β-strand | 686 | 1 | 37 |
| β-strand | 689-690 | 2 | 38 |
| α-helix | 706-711 | 6 | |
| α-helix | 713-716 | 4 | |
Chain 7: 35 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-4 | 3 | 51 |
| β-strand | 9-11 | 3 | 51 |
| α-helix | 20-33 | 14 | |
| β-strand | 39-41 | 3 | 52 |
| α-helix | 48-62 | 15 | |
| β-strand | 69-73 | 5 | 52 |
| α-helix | 77-97 | 21 | |
| β-strand | 106-108 | 3 | 52 |
| α-helix | 127-137 | 11 | |
| α-helix | 142-147 | 6 | |
| α-helix | 157-160 | 4 | |
| α-helix | 161-165 | 5 | |
| β-strand | 175 | 1 | 52 |
| α-helix | 177-183 | 7 | |
| α-helix | 184-188 | 5 | |
| α-helix | 191-197 | 7 | |
| β-strand | 204-207 | 4 | 52 |
| α-helix | 223-226 | 4 | |
| β-strand | 229-234 | 6 | 52 |
| α-helix | 239-247 | 9 | |
| β-strand | 249-252 | 4 | 53 |
| α-helix | 253-276 | 24 | |
| α-helix | 279-289 | 11 | |
| α-helix | 326-344 | 19 | |
| β-strand | 350-352 | 3 | 53 |
| α-helix | 354-364 | 11 | |
| α-helix | 370-373 | 4 | |
| α-helix | 375-385 | 11 | |
| α-helix | 391-394 | 4 | |
| α-helix | 395-407 | 13 | |
| β-strand | 414-419 | 6 | 53 |
| β-strand | 432-437 | 6 | 53 |
| α-helix | 441-450 | 10 | |
| β-strand | 455-457 | 3 | 52 |
| α-helix | 466-470 | 5 | |
| β-strand | 478-480 | 3 | 52 |
| α-helix | 481 | 1 | |
| β-strand | 490-494 | 5 | 54 |
| α-helix | 514-530 | 17 | |
| β-strand | 536-539 | 4 | 54 |
| α-helix | 542-550 | 9 | |
| α-helix | 558-564 | 7 | |
| β-strand | 566-569 | 4 | 54 |
| α-helix | 576-590 | 15 | |
| β-strand | 594-599 | 6 | 54 |
| α-helix | 603-605 | 3 | |
| β-strand | 617-621 | 5 | 54 |
| α-helix | 632-642 | 11 | |
| α-helix | 648-663 | 16 | |
| β-strand | 675-680 | 6 | 54 |
| α-helix | 682-685 | 4 | |
| α-helix | 690-692 | 3 | |
| α-helix | 695-698 | 4 | |
| β-strand | 706 | 1 | 54 |
| α-helix | 710-723 | 14 | |
| α-helix | 730-732 | 3 | |
41 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| CDK-activating kinase assembly factor MAT1 | 0 | protein | 309 | Homo sapiens | P51948 (AlphaFold model) |
| General transcription factor IIH subunit 1 | 1 | protein | 548 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 2 | 2 | protein | 395 | Homo sapiens | Q13888 (AlphaFold model) |
| General transcription factor IIH subunit 3 | 3 | protein | 308 | Homo sapiens | Q13889 (AlphaFold model) |
| General transcription factor IIH subunit 4 | 4 | protein | 462 | Homo sapiens | Q92759 |
| General transcription factor IIH subunit 5 | 5 | protein | 71 | Homo sapiens | Q6ZYL4 |
| General transcription and DNA repair factor IIH helicase subunit XPB | 6 | protein | 782 | Homo sapiens | P19447 |
| General transcription and DNA repair factor IIH helicase subunit XPD | 7 | protein | 760 | Homo sapiens | P18074 |
| Cyclin-dependent kinase 7 | 8 | protein | 346 | Homo sapiens | P50613 |
| Cyclin-H | 9 | protein | 323 | Homo sapiens | P51946 |
| Transcription initiation factor TFIID subunit 1 | A | protein | 1872 | Homo sapiens | P21675 |
| Transcription initiation factor TFIID subunit 2 | B | protein | 1199 | Homo sapiens | Q6P1X5 |
33 more molecules are not listed.
Sequence of entity 1 (0), FASTA
>7EGC_1 CDK-activating kinase assembly factor MAT1 (chains 0)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 2 (1), FASTA
>7EGC_2 General transcription factor IIH subunit 1 (chains 1)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Sequence of entity 3 (2), FASTA
>7EGC_3 General transcription factor IIH subunit 2 (chains 2)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 4 (3), FASTA
>7EGC_4 General transcription factor IIH subunit 3 (chains 3)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 5 (4), FASTA
>7EGC_5 General transcription factor IIH subunit 4 (chains 4)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 6 (5), FASTA
>7EGC_6 General transcription factor IIH subunit 5 (chains 5)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 7 (6), FASTA
>7EGC_7 General transcription and DNA repair factor IIH helicase subunit XPB (chains 6)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK
Sequence of entity 8 (7), FASTA
>7EGC_8 General transcription and DNA repair factor IIH helicase subunit XPD (chains 7)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
Sequence of entity 9 (8), FASTA
>7EGC_9 Cyclin-dependent kinase 7 (chains 8)
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Sequence of entity 10 (9), FASTA
>7EGC_10 Cyclin-H (chains 9)
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
Sequence of entity 11 (A), FASTA
>7EGC_11 Transcription initiation factor TFIID subunit 1 (chains A)
MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA
IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY
GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH
SIAGDSDLDSDE
Sequence of entity 12 (B), FASTA
>7EGC_12 Transcription initiation factor TFIID subunit 2 (chains B)
MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANL
NRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPD
AGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSC
GYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTI
PTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYP
YSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFIS
RMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGG
GKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLA
STASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRK
RNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNK
KKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVV
AQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMK
SLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIK
YNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNME
KLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKV
DRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSG
TSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEA
ANNPSSHPQLVGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPAS
SRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTA
SKHSDHHHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 16 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| MG | Magnesium ion | Mg | 1 |
Primary citation
Structural insights into preinitiation complex assembly on core promoters. Chen, X., Qi, Y., Wu, Z. et al. Science (2021) 372. DOI 10.1126/science.aba8490 · PubMed
Other PDB entries of the same protein (UniProt P51948 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8P79 1.7 Å, Cryo-EM structure of CAK with averaged inhibitor density
- 8P77 1.8 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0943
- 8ORM 1.9 Å, Cryo-EM structure of CAK-THZ1
- 8P6V 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0942
- 8P6W 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor BS-181
- 8P6X 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor BS-194
- 8P6Y 1.9 Å, Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
- 8P72 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0768
- 8P78 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor dinaciclib
- 8PLZ 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor CT7030
- 8P70 2.0 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0510-S
- 8P71 2.0 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0574
Browse structure collections
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