7ENA: CDK-activating kinase assembly factor MAT1
TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED). Determined by electron microscopy at 4.07 Å resolution. Released 26 May 2021.
- Method
- Electron microscopy
- Resolution
- 4.07 Å
- Organisms
- Homo sapiens, Sus scrofa
- Chains
- 76
- Atoms
- 173,965
- Mol. weight
- 3882.08 kDa
- Ligands
- SF4, MG, ZN
- Released
- 26 May 2021
Explore 7ENA in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ENA contains 934 α-helices and 740 β-strands across 74 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 12 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-15 | 4 | |
| β-strand | 21-23 | 3 | 1 |
| β-strand | 31 | 1 | 1 |
| α-helix | 32-40 | 9 | |
| β-strand | 45 | 1 | 2 |
| β-strand | 52 | 1 | 2 |
| β-strand | 59-61 | 3 | 1 |
| α-helix | 69-86 | 18 | |
| α-helix | 90-92 | 3 | |
| α-helix | 97-110 | 14 | |
| α-helix | 117-120 | 4 | |
| α-helix | 129-187 | 59 | |
| α-helix | 198-210 | 13 | |
| α-helix | 215-218 | 4 | |
| α-helix | 267-271 | 5 | |
| α-helix | 281-285 | 5 | |
| α-helix | 289-301 | 13 | |
Chain 1: 22 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 115-120 | 6 | |
| α-helix | 122-133 | 12 | |
| α-helix | 139-145 | 7 | |
| α-helix | 150-153 | 4 | |
| α-helix | 154-156 | 3 | |
| α-helix | 194-197 | 4 | |
| α-helix | 202-210 | 9 | |
| α-helix | 217-230 | 14 | |
| α-helix | 237-260 | 24 | |
| α-helix | 265-270 | 6 | |
| α-helix | 296-322 | 27 | |
| α-helix | 352-365 | 14 | |
| α-helix | 375-383 | 9 | |
| α-helix | 391-409 | 19 | |
| α-helix | 421-434 | 14 | |
| α-helix | 449-452 | 4 | |
| α-helix | 454-476 | 23 | |
| α-helix | 479-481 | 3 | |
| α-helix | 487-501 | 15 | |
| α-helix | 505-509 | 5 | |
| α-helix | 516-519 | 4 | |
| α-helix | 522-539 | 18 | |
Chain 2: 16 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-14 | 4 | |
| α-helix | 17-23 | 7 | |
| α-helix | 34-41 | 8 | |
| β-strand | 60-67 | 8 | 156 |
| α-helix | 69-72 | 4 | |
| β-strand | 75 | 1 | 157 |
| β-strand | 77 | 1 | 157 |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 156 |
| β-strand | 115-121 | 7 | 156 |
| α-helix | 124-133 | 10 | |
| α-helix | 134-136 | 3 | |
| α-helix | 145-157 | 13 | |
| β-strand | 168-171 | 4 | 156 |
| α-helix | 185-192 | 8 | |
| β-strand | 197-200 | 4 | 156 |
| α-helix | 206-213 | 8 | |
| β-strand | 220-221 | 2 | 156 |
| α-helix | 225-236 | 12 | |
| β-strand | 249-253 | 5 | 158 |
| β-strand | 256-257 | 2 | 159 |
| β-strand | 278 | 1 | 160 |
| β-strand | 289-290 | 2 | 159 |
| β-strand | 297 | 1 | 160 |
| β-strand | 311 | 1 | 158 |
| α-helix | 315-318 | 4 | |
| α-helix | 322-324 | 3 | |
| β-strand | 331-334 | 4 | 161 |
| α-helix | 340-343 | 4 | |
| β-strand | 357-360 | 4 | 161 |
| β-strand | 366-367 | 2 | 161 |
| α-helix | 369-373 | 5 | |
| α-helix | 374-379 | 6 | |
Chain 3: 8 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10 | 1 | 163 |
| β-strand | 12-14 | 3 | 164 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-49 | 16 | |
| β-strand | 56 | 1 | 163 |
| β-strand | 59-60 | 2 | 164 |
| β-strand | 69-71 | 3 | 164 |
| α-helix | 102-118 | 17 | |
| α-helix | 133-148 | 16 | |
| β-strand | 160-164 | 5 | 164 |
| α-helix | 174-187 | 14 | |
| β-strand | 190-195 | 6 | 164 |
| α-helix | 201-210 | 10 | |
| β-strand | 213-216 | 4 | 164 |
| α-helix | 226-229 | 4 | |
| β-strand | 264-267 | 4 | 158 |
| β-strand | 274 | 1 | 158 |
| α-helix | 288-290 | 3 | |
Chain 4: 23 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-33 | 6 | |
| α-helix | 39-46 | 8 | |
| α-helix | 52-55 | 4 | |
| α-helix | 68-72 | 5 | |
| α-helix | 80-92 | 13 | |
| β-strand | 96-97 | 2 | 170 |
| β-strand | 109-110 | 2 | 170 |
| α-helix | 112-120 | 9 | |
| α-helix | 145-164 | 20 | |
| α-helix | 176-179 | 4 | |
| α-helix | 199-204 | 6 | |
| α-helix | 210-217 | 8 | |
| α-helix | 228-238 | 11 | |
| α-helix | 249-252 | 4 | |
| α-helix | 256-267 | 12 | |
| α-helix | 275-277 | 3 | |
| α-helix | 288-292 | 5 | |
| α-helix | 310-312 | 3 | |
| α-helix | 322-329 | 8 | |
| α-helix | 349-352 | 4 | |
| α-helix | 361-368 | 8 | |
| α-helix | 387-401 | 15 | |
| α-helix | 415-428 | 14 | |
| β-strand | 435 | 1 | 171 |
| β-strand | 440 | 1 | 171 |
| α-helix | 445-447 | 3 | |
| α-helix | 448-461 | 14 | |
Chain 5: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8 | 1 | 173 |
| α-helix | 14-17 | 4 | |
| α-helix | 19-25 | 7 | |
| β-strand | 45 | 1 | 173 |
| α-helix | 50-56 | 7 | |
| α-helix | 58-66 | 9 | |
Chain 6: 29 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 53-64 | 12 | |
| α-helix | 94-97 | 4 | |
| α-helix | 133-142 | 10 | |
| α-helix | 154-156 | 3 | |
| β-strand | 161 | 1 | 178 |
| β-strand | 164-165 | 2 | 179 |
| α-helix | 185-188 | 4 | |
| α-helix | 191-194 | 4 | |
| α-helix | 247-258 | 12 | |
| α-helix | 278-285 | 8 | |
| β-strand | 290 | 1 | 178 |
| β-strand | 293-294 | 2 | 179 |
| α-helix | 318-327 | 10 | |
| β-strand | 338-339 | 2 | 180 |
| α-helix | 346-356 | 11 | |
| β-strand | 362-365 | 4 | 181 |
| α-helix | 368-381 | 14 | |
| β-strand | 390-391 | 2 | 181 |
| β-strand | 406-409 | 4 | 181 |
| α-helix | 422-433 | 12 | |
| β-strand | 438-441 | 4 | 181 |
| α-helix | 448-457 | 10 | |
| β-strand | 463-466 | 4 | 181 |
| α-helix | 481-484 | 4 | |
| β-strand | 489-490 | 2 | 180 |
| α-helix | 494-497 | 4 | |
| α-helix | 502-504 | 3 | |
| β-strand | 505-507 | 3 | 182 |
| β-strand | 509-512 | 4 | 182 |
| α-helix | 516-518 | 3 | |
| α-helix | 519-524 | 6 | |
| α-helix | 529-535 | 7 | |
| α-helix | 538-552 | 15 | |
| β-strand | 558-561 | 4 | 182 |
| α-helix | 565-574 | 10 | |
| α-helix | 586-593 | 8 | |
| α-helix | 594-598 | 5 | |
| β-strand | 606-607 | 2 | 182 |
| α-helix | 609-610 | 2 | |
| α-helix | 611-615 | 5 | |
| β-strand | 620 | 1 | 183 |
| β-strand | 622-625 | 4 | 182 |
| α-helix | 633-643 | 11 | |
| β-strand | 644 | 1 | 183 |
| β-strand | 657-664 | 8 | 182 |
| α-helix | 668-683 | 16 | |
| β-strand | 686-687 | 2 | 182 |
| α-helix | 706-717 | 12 | |
| α-helix | 721-723 | 3 | |
Chain 7: 31 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-28 | 8 | |
| α-helix | 29-33 | 5 | |
| β-strand | 39-40 | 2 | 207 |
| α-helix | 52-61 | 10 | |
| β-strand | 71-74 | 4 | 207 |
| α-helix | 77-97 | 21 | |
| β-strand | 107-108 | 2 | 207 |
| α-helix | 128-136 | 9 | |
| α-helix | 137-141 | 5 | |
| α-helix | 156-166 | 11 | |
| α-helix | 179-182 | 4 | |
| α-helix | 191-199 | 9 | |
| β-strand | 205-208 | 4 | 207 |
| α-helix | 209-212 | 4 | |
| β-strand | 231-234 | 4 | 207 |
| α-helix | 239-247 | 9 | |
| β-strand | 249-250 | 2 | 208 |
| α-helix | 253-272 | 20 | |
| α-helix | 278-290 | 13 | |
| α-helix | 325-341 | 17 | |
| α-helix | 344-348 | 5 | |
| α-helix | 354-364 | 11 | |
| α-helix | 376-384 | 9 | |
| α-helix | 391-409 | 19 | |
| β-strand | 415-418 | 4 | 208 |
| β-strand | 433-436 | 4 | 208 |
| α-helix | 441-450 | 10 | |
| β-strand | 455-457 | 3 | 207 |
| α-helix | 464-466 | 3 | |
| β-strand | 477 | 1 | 207 |
| β-strand | 491-494 | 4 | 209 |
| α-helix | 517-519 | 3 | |
| α-helix | 520-530 | 11 | |
| β-strand | 536-539 | 4 | 210 |
| α-helix | 542-548 | 7 | |
| α-helix | 550-554 | 5 | |
| α-helix | 558-564 | 7 | |
| β-strand | 568 | 1 | 210 |
| α-helix | 574-589 | 16 | |
| β-strand | 596-599 | 4 | 210 |
| β-strand | 611 | 1 | 211 |
| β-strand | 614 | 1 | 211 |
| β-strand | 617-619 | 3 | 209 |
| α-helix | 632-641 | 10 | |
| α-helix | 648-663 | 16 | |
| β-strand | 676-679 | 4 | 209 |
| α-helix | 687-691 | 5 | |
| α-helix | 694-699 | 6 | |
| α-helix | 710-724 | 15 | |
66 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| CDK-activating kinase assembly factor MAT1 | 0 | protein | 309 | Homo sapiens | P51948 (AlphaFold model) |
| Cyclin-dependent kinase 7 | 8 | protein | 346 | Homo sapiens | P50613 (AlphaFold model) |
| Cyclin-H | 9 | protein | 323 | Homo sapiens | P51946 (AlphaFold model) |
| Transcription initiation factor IIA subunit 2 | DO | protein | 109 | Homo sapiens | P52657 (AlphaFold model) |
| TATA-box-binding protein | DP | protein | 339 | Homo sapiens | P20226 |
| TFIIA-a | DQ | protein | 307 | Homo sapiens | |
| Transcription initiation factor IIB | BA | protein | 316 | Homo sapiens | Q00403 |
| General transcription factor IIF subunit 1 | FA | protein | 517 | Homo sapiens | P35269 |
| General transcription factor IIF subunit 2 | FB | protein | 249 | Homo sapiens | P13984 |
| RPB1 | PA | protein | 1970 | Sus scrofa | |
| DNA-directed RNA polymerase subunit beta | PB | protein | 1174 | Sus scrofa | A0A4X1TVZ5 |
| DNA-directed RNA polymerase II subunit RPB3 | PC | protein | 275 | Sus scrofa | I3LCH3 |
58 more molecules are not listed.
Sequence of entity 1 (0), FASTA
>7ENA_1 CDK-activating kinase assembly factor MAT1 (chains 0)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 2 (8), FASTA
>7ENA_2 Cyclin-dependent kinase 7 (chains 8)
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Sequence of entity 3 (9), FASTA
>7ENA_3 Cyclin-H (chains 9)
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
Sequence of entity 4 (DO), FASTA
>7ENA_4 Transcription initiation factor IIA subunit 2 (chains DO)
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRG
SLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE
Sequence of entity 5 (DP), FASTA
>7ENA_5 TATA-box-binding protein (chains DP)
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQ
LFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDL
KTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV
VQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRI
VLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT
Sequence of entity 6 (DQ), FASTA
>7ENA_6 TFIIA-a (chains DQ)
MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFH
SEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIV
PDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQ
SVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTV
EEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSK
AIGDAEW
Sequence of entity 7 (BA), FASTA
>7ENA_7 Transcription initiation factor IIB (chains BA)
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKA
TKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKE
ITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEI
CAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAV
ELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLF
PTDFKFDTPVDKLPQL
Sequence of entity 8 (FA), FASTA
>7ENA_8 General transcription factor IIF subunit 1 (chains FA)
MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEE
EMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTE
NTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQR
RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL
AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG
VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA
LFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAA
KRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK
KTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE
Sequence of entity 9 (FB), FASTA
>7ENA_9 General transcription factor IIF subunit 2 (chains FB)
MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNE
DLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAA
SENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADK
QHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR
HYQGEEKSD
Sequence of entity 10 (PA), FASTA
>7ENA_10 RPB1 (chains PA)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 11 (PB), FASTA
>7ENA_11 DNA-directed RNA polymerase subunit beta (chains PB)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Sequence of entity 12 (PC), FASTA
>7ENA_12 DNA-directed RNA polymerase II subunit RPB3 (chains PC)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| MG | Magnesium ion | Mg | 1 |
| ZN | Zinc ion | Zn | 16 |
Primary citation
Structures of the human Mediator and Mediator-bound preinitiation complex. Chen, X., Yin, X., Li, J. et al. Science (2021) 372. DOI 10.1126/science.abg0635 · PubMed
Other PDB entries of the same protein (UniProt P51948 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8P79 1.7 Å, Cryo-EM structure of CAK with averaged inhibitor density
- 8P77 1.8 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0943
- 8ORM 1.9 Å, Cryo-EM structure of CAK-THZ1
- 8P6V 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0942
- 8P6W 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor BS-181
- 8P6X 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor BS-194
- 8P6Y 1.9 Å, Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
- 8P72 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0768
- 8P78 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor dinaciclib
- 8PLZ 1.9 Å, Cryo-EM structure of CAK in complex with inhibitor CT7030
- 8P70 2.0 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0510-S
- 8P71 2.0 Å, Cryo-EM structure of CAK in complex with inhibitor ICEC0574
Browse structure collections
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