7ENC: PDB entry 7ENC

TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED). Determined by electron microscopy at 4.13 Å resolution. Released 26 May 2021.

Method
Electron microscopy
Resolution
4.13 Å
Organisms
Homo sapiens, Sus scrofa
Chains
76
Atoms
171,177
Mol. weight
3882.04 kDa
Ligands
MG, SF4, ZN
Released
26 May 2021

Explore 7ENC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ENC contains 941 α-helices and 720 β-strands across 74 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 14 helices, 3 β-strands

ElementResiduesLengthSheet
β-strand22-243196
β-strand29-302196
α-helix32-398
α-helix43-453
β-strand58-592196
α-helix69-779
α-helix78-825
α-helix83-919
α-helix97-11014
α-helix116-12611
α-helix129-18759
α-helix196-21116
α-helix215-2184
α-helix229-2324
α-helix267-2715
α-helix280-2856
α-helix289-30113
Chain 1: 16 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix108-12013
α-helix122-13413
α-helix139-1468
α-helix191-1999
α-helix201-21010
α-helix217-2248
α-helix241-25414
α-helix296-31823
α-helix347-35711
α-helix361-3644
β-strand3731210
α-helix379-3835
α-helix397-41216
α-helix420-43415
α-helix454-47825
α-helix486-51227
α-helix523-54624
Chain 2: 14 helices, 21 β-strands
ElementResiduesLengthSheet
β-strand531210
β-strand5517
β-strand59-6688
α-helix69-724
α-helix80-9819
β-strand103-11088
β-strand113-12198
α-helix124-13613
α-helix145-15814
β-strand164-17188
α-helix182-19110
β-strand195-20068
α-helix206-21510
β-strand220-22128
α-helix225-23612
α-helix238-2392
β-strand24017
α-helix241-2422
β-strand250-25349
β-strand257-258210
β-strand270111
β-strand285111
β-strand288-290310
β-strand297-298210
β-strand31219
α-helix315-32511
α-helix327-3304
β-strand332-334312
β-strand344-345213
β-strand350-351213
β-strand357-359312
β-strand366-367212
α-helix369-3746
α-helix375-3795
α-helix383-3864
Chain 3: 14 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand10-16714
α-helix19-2810
α-helix34-5118
β-strand56-62714
β-strand67-69314
α-helix102-12019
α-helix133-15018
β-strand159-165714
α-helix168-1692
α-helix173-18614
β-strand190-195614
α-helix201-21010
β-strand214-216314
α-helix220-2223
α-helix223-2264
α-helix227-2315
α-helix235-2406
β-strand241115
α-helix244-2485
β-strand254-255216
β-strand260-261216
β-strand264-26749
β-strand274-27529
β-strand281117
α-helix2871
β-strand288117
α-helix289-2902
Chain 4: 20 helices, 15 β-strands
ElementResiduesLengthSheet
α-helix28-358
α-helix38-4710
α-helix50-6011
β-strand66-67219
α-helix68-747
β-strand75115
α-helix77-9317
β-strand96-99419
β-strand107-110419
α-helix112-12211
α-helix142-1443
α-helix145-16117
α-helix174-1829
β-strand185-187320
β-strand194-196320
α-helix198-2058
α-helix208-22619
α-helix230-24112
β-strand249-250221
α-helix256-26813
β-strand271-272222
β-strand280-281221
β-strand282-283222
α-helix285-2895
β-strand307-308223
β-strand314-317423
α-helix322-33110
β-strand333-337523
β-strand342-345423
α-helix348-35710
α-helix361-37010
β-strand372123
α-helix387-40014
α-helix415-42814
α-helix448-46114
Chain 5: 2 helices, 3 β-strands
ElementResiduesLengthSheet
β-strand9-11328
α-helix14-2613
β-strand34-36328
β-strand42-45428
α-helix50-5910
Chain 6: 30 helices, 24 β-strands
ElementResiduesLengthSheet
β-strand59-60223
β-strand76-77229
β-strand83-87529
α-helix93-10311
β-strand104-108529
β-strand113-118629
α-helix120-12910
α-helix133-14311
β-strand144129
α-helix147-1493
α-helix150-16011
β-strand166-171630
β-strand174-179630
α-helix182-1909
α-helix192-1976
β-strand198130
β-strand268-272530
α-helix274-28613
β-strand291-295530
α-helix304-3052
α-helix318-32811
β-strand336-339431
α-helix346-35712
β-strand363-364231
α-helix368-38114
α-helix384-3874
α-helix393-3953
α-helix400-4034
β-strand407-408231
α-helix421-43313
α-helix4371
β-strand438-441431
α-helix4471
α-helix450-4578
β-strand463-466431
α-helix481-4844
β-strand487-490431
α-helix493-4997
β-strand506-513832
α-helix514-5152
α-helix516-5249
α-helix528-5358
α-helix538-55417
β-strand558-561432
α-helix565-57511
β-strand579-580232
α-helix586-59712
β-strand604-607432
β-strand623-625332
α-helix633-64311
β-strand658-665832
α-helix670-68314
β-strand686-690532
α-helix706-71813
Chain 7: 40 helices, 20 β-strands
ElementResiduesLengthSheet
β-strand3-4234
β-strand9-10234
α-helix19-3315
β-strand39135
β-strand40-41236
α-helix48-6215
β-strand70-74535
α-helix77-9721
β-strand106-108335
α-helix127-13711
α-helix140-1489
α-helix158-1603
α-helix161-1655
α-helix177-18711
α-helix191-1977
β-strand204-207435
α-helix209-2135
α-helix223-2286
β-strand230-234535
α-helix236-2383
α-helix239-2479
β-strand250-252337
α-helix253-27624
α-helix279-29012
α-helix294-2985
α-helix312-3143
α-helix326-34520
β-strand350-352337
α-helix354-36411
α-helix369-3735
α-helix375-38612
α-helix391-40919
β-strand415-419537
β-strand432-436537
α-helix440-4434
α-helix445-4506
β-strand453-456435
α-helix466-4716
β-strand479-480236
β-strand490-494538
α-helix506-5083
α-helix514-53017
β-strand535-539538
α-helix542-55413
α-helix558-5647
β-strand566-567238
α-helix574-59017
β-strand594-599638
α-helix603-6075
α-helix609-6113
β-strand617-620438
α-helix631-64313
α-helix648-66417
β-strand675-679538
α-helix682-6865
α-helix688-6925
α-helix695-7006
α-helix710-72516
α-helix727-7282
α-helix730-7334

66 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Mediator of RNA polymerase II transcription subunit 1aprotein1581Homo sapiensQ15648 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 31mprotein131Homo sapiensQ9Y3C7 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 4dprotein270Homo sapiensQ9NPJ6 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 6fprotein246Homo sapiensO75586 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 7gprotein233Homo sapiensO43513
Isoform 2 of Mediator of RNA polymerase II transcription subunit 8hprotein268Homo sapiensQ96G25
Mediator of RNA polymerase II transcription subunit 18rprotein208Homo sapiensQ9BUE0
Mediator of RNA polymerase II transcription subunit 20tprotein212Homo sapiensQ9H944
Mediator of RNA polymerase II transcription subunit 10jprotein135Homo sapiensQ9BTT4
Mediator of RNA polymerase II transcription subunit 11kprotein117Homo sapiensQ9P086
Mediator of RNA polymerase II transcription subunit 14nprotein1454Homo sapiensO60244
Mediator of RNA polymerase II transcription subunit 17qprotein651Homo sapiensQ9NVC6

58 more molecules are not listed.

Sequence of entity 1 (a), FASTA
>7ENC_1 Mediator of RNA polymerase II transcription subunit 1 (chains a)
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SPDFMIGEEDDDLMDVALIGN
Sequence of entity 2 (m), FASTA
>7ENC_2 Mediator of RNA polymerase II transcription subunit 31 (chains m)
MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKD
PEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALA
EQQQQNNTSGK
Sequence of entity 3 (d), FASTA
>7ENC_3 Mediator of RNA polymerase II transcription subunit 4 (chains d)
MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAG
EENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQI
LATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDL
EMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDF
LLEPPGHNKENEDDVEIMSTDSSSSSSESD
Sequence of entity 4 (f), FASTA
>7ENC_4 Mediator of RNA polymerase II transcription subunit 6 (chains f)
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHL
NQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVL
TAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDAL
LLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPE
KRMRLQ
Sequence of entity 5 (g), FASTA
>7ENC_5 Mediator of RNA polymerase II transcription subunit 7 (chains g)
MGEPQQVSAALPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLE
SQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVH
HLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEA
GMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP
Sequence of entity 6 (h), FASTA
>7ENC_6 Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 (chains h)
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLN
KVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQ
EKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNA
LVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQ
MAQAGQPGKMPSGIKTNIKSASMHPYQR
Sequence of entity 7 (r), FASTA
>7ENC_7 Mediator of RNA polymerase II transcription subunit 18 (chains r)
MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLL
KGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLME
MGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQD
MVSDDMKNFAEQLKPLVHLEKIDPKRLM
Sequence of entity 8 (t), FASTA
>7ENC_8 Mediator of RNA polymerase II transcription subunit 20 (chains t)
MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTG
KLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYC
DFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRH
DAVYGPADTMVQYMELFNKIRKQQQVPVAGIR
Sequence of entity 9 (j), FASTA
>7ENC_9 Mediator of RNA polymerase II transcription subunit 10 (chains j)
MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHD
ITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPED
MAKYRSIRGEDHPPS
Sequence of entity 10 (k), FASTA
>7ENC_10 Mediator of RNA polymerase II transcription subunit 11 (chains k)
MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVE
AELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN
Sequence of entity 11 (n), FASTA
>7ENC_11 Mediator of RNA polymerase II transcription subunit 14 (chains n)
MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLH
RAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISS
FLDQQAILFVDTLDRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPP
DPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDD
PDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFC
LSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIK
IDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAIL
RGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEK
SVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFI
KLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVF
RTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLE
LSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTW
VAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECV
LEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGP
NSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTA
YQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLK
TFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYP
LTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGP
GASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPD
ASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAG
SYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQT
LQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIM
KLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEP
VSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVR
DLMANLTLPPGGRP
Sequence of entity 12 (q), FASTA
>7ENC_12 Mediator of RNA polymerase II transcription subunit 17 (chains q)
MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEA
AGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVR
DKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQ
RDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDY
CPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQN
VLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATE
KQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINS
LQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLIT
SQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQL
AKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQ
CKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg1
SF4Iron/sulfur clusterFe4 S41
ZNZinc ionZn16

Primary citation

Structures of the human Mediator and Mediator-bound preinitiation complex. Chen, X., Yin, X., Li, J. et al. Science (2021) 372. DOI 10.1126/science.abg0635 · PubMed

Other PDB entries of the same protein (UniProt Q15648 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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