7ENC: PDB entry 7ENC
TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED). Determined by electron microscopy at 4.13 Å resolution. Released 26 May 2021.
- Method
- Electron microscopy
- Resolution
- 4.13 Å
- Organisms
- Homo sapiens, Sus scrofa
- Chains
- 76
- Atoms
- 171,177
- Mol. weight
- 3882.04 kDa
- Ligands
- MG, SF4, ZN
- Released
- 26 May 2021
Explore 7ENC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ENC contains 941 α-helices and 720 β-strands across 74 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 14 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-24 | 3 | 196 |
| β-strand | 29-30 | 2 | 196 |
| α-helix | 32-39 | 8 | |
| α-helix | 43-45 | 3 | |
| β-strand | 58-59 | 2 | 196 |
| α-helix | 69-77 | 9 | |
| α-helix | 78-82 | 5 | |
| α-helix | 83-91 | 9 | |
| α-helix | 97-110 | 14 | |
| α-helix | 116-126 | 11 | |
| α-helix | 129-187 | 59 | |
| α-helix | 196-211 | 16 | |
| α-helix | 215-218 | 4 | |
| α-helix | 229-232 | 4 | |
| α-helix | 267-271 | 5 | |
| α-helix | 280-285 | 6 | |
| α-helix | 289-301 | 13 | |
Chain 1: 16 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 108-120 | 13 | |
| α-helix | 122-134 | 13 | |
| α-helix | 139-146 | 8 | |
| α-helix | 191-199 | 9 | |
| α-helix | 201-210 | 10 | |
| α-helix | 217-224 | 8 | |
| α-helix | 241-254 | 14 | |
| α-helix | 296-318 | 23 | |
| α-helix | 347-357 | 11 | |
| α-helix | 361-364 | 4 | |
| β-strand | 373 | 1 | 210 |
| α-helix | 379-383 | 5 | |
| α-helix | 397-412 | 16 | |
| α-helix | 420-434 | 15 | |
| α-helix | 454-478 | 25 | |
| α-helix | 486-512 | 27 | |
| α-helix | 523-546 | 24 | |
Chain 2: 14 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 53 | 1 | 210 |
| β-strand | 55 | 1 | 7 |
| β-strand | 59-66 | 8 | 8 |
| α-helix | 69-72 | 4 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 8 |
| β-strand | 113-121 | 9 | 8 |
| α-helix | 124-136 | 13 | |
| α-helix | 145-158 | 14 | |
| β-strand | 164-171 | 8 | 8 |
| α-helix | 182-191 | 10 | |
| β-strand | 195-200 | 6 | 8 |
| α-helix | 206-215 | 10 | |
| β-strand | 220-221 | 2 | 8 |
| α-helix | 225-236 | 12 | |
| α-helix | 238-239 | 2 | |
| β-strand | 240 | 1 | 7 |
| α-helix | 241-242 | 2 | |
| β-strand | 250-253 | 4 | 9 |
| β-strand | 257-258 | 2 | 10 |
| β-strand | 270 | 1 | 11 |
| β-strand | 285 | 1 | 11 |
| β-strand | 288-290 | 3 | 10 |
| β-strand | 297-298 | 2 | 10 |
| β-strand | 312 | 1 | 9 |
| α-helix | 315-325 | 11 | |
| α-helix | 327-330 | 4 | |
| β-strand | 332-334 | 3 | 12 |
| β-strand | 344-345 | 2 | 13 |
| β-strand | 350-351 | 2 | 13 |
| β-strand | 357-359 | 3 | 12 |
| β-strand | 366-367 | 2 | 12 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain 3: 14 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-16 | 7 | 14 |
| α-helix | 19-28 | 10 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 14 |
| β-strand | 67-69 | 3 | 14 |
| α-helix | 102-120 | 19 | |
| α-helix | 133-150 | 18 | |
| β-strand | 159-165 | 7 | 14 |
| α-helix | 168-169 | 2 | |
| α-helix | 173-186 | 14 | |
| β-strand | 190-195 | 6 | 14 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 14 |
| α-helix | 220-222 | 3 | |
| α-helix | 223-226 | 4 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-240 | 6 | |
| β-strand | 241 | 1 | 15 |
| α-helix | 244-248 | 5 | |
| β-strand | 254-255 | 2 | 16 |
| β-strand | 260-261 | 2 | 16 |
| β-strand | 264-267 | 4 | 9 |
| β-strand | 274-275 | 2 | 9 |
| β-strand | 281 | 1 | 17 |
| α-helix | 287 | 1 | |
| β-strand | 288 | 1 | 17 |
| α-helix | 289-290 | 2 | |
Chain 4: 20 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-35 | 8 | |
| α-helix | 38-47 | 10 | |
| α-helix | 50-60 | 11 | |
| β-strand | 66-67 | 2 | 19 |
| α-helix | 68-74 | 7 | |
| β-strand | 75 | 1 | 15 |
| α-helix | 77-93 | 17 | |
| β-strand | 96-99 | 4 | 19 |
| β-strand | 107-110 | 4 | 19 |
| α-helix | 112-122 | 11 | |
| α-helix | 142-144 | 3 | |
| α-helix | 145-161 | 17 | |
| α-helix | 174-182 | 9 | |
| β-strand | 185-187 | 3 | 20 |
| β-strand | 194-196 | 3 | 20 |
| α-helix | 198-205 | 8 | |
| α-helix | 208-226 | 19 | |
| α-helix | 230-241 | 12 | |
| β-strand | 249-250 | 2 | 21 |
| α-helix | 256-268 | 13 | |
| β-strand | 271-272 | 2 | 22 |
| β-strand | 280-281 | 2 | 21 |
| β-strand | 282-283 | 2 | 22 |
| α-helix | 285-289 | 5 | |
| β-strand | 307-308 | 2 | 23 |
| β-strand | 314-317 | 4 | 23 |
| α-helix | 322-331 | 10 | |
| β-strand | 333-337 | 5 | 23 |
| β-strand | 342-345 | 4 | 23 |
| α-helix | 348-357 | 10 | |
| α-helix | 361-370 | 10 | |
| β-strand | 372 | 1 | 23 |
| α-helix | 387-400 | 14 | |
| α-helix | 415-428 | 14 | |
| α-helix | 448-461 | 14 | |
Chain 5: 2 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-11 | 3 | 28 |
| α-helix | 14-26 | 13 | |
| β-strand | 34-36 | 3 | 28 |
| β-strand | 42-45 | 4 | 28 |
| α-helix | 50-59 | 10 | |
Chain 6: 30 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 59-60 | 2 | 23 |
| β-strand | 76-77 | 2 | 29 |
| β-strand | 83-87 | 5 | 29 |
| α-helix | 93-103 | 11 | |
| β-strand | 104-108 | 5 | 29 |
| β-strand | 113-118 | 6 | 29 |
| α-helix | 120-129 | 10 | |
| α-helix | 133-143 | 11 | |
| β-strand | 144 | 1 | 29 |
| α-helix | 147-149 | 3 | |
| α-helix | 150-160 | 11 | |
| β-strand | 166-171 | 6 | 30 |
| β-strand | 174-179 | 6 | 30 |
| α-helix | 182-190 | 9 | |
| α-helix | 192-197 | 6 | |
| β-strand | 198 | 1 | 30 |
| β-strand | 268-272 | 5 | 30 |
| α-helix | 274-286 | 13 | |
| β-strand | 291-295 | 5 | 30 |
| α-helix | 304-305 | 2 | |
| α-helix | 318-328 | 11 | |
| β-strand | 336-339 | 4 | 31 |
| α-helix | 346-357 | 12 | |
| β-strand | 363-364 | 2 | 31 |
| α-helix | 368-381 | 14 | |
| α-helix | 384-387 | 4 | |
| α-helix | 393-395 | 3 | |
| α-helix | 400-403 | 4 | |
| β-strand | 407-408 | 2 | 31 |
| α-helix | 421-433 | 13 | |
| α-helix | 437 | 1 | |
| β-strand | 438-441 | 4 | 31 |
| α-helix | 447 | 1 | |
| α-helix | 450-457 | 8 | |
| β-strand | 463-466 | 4 | 31 |
| α-helix | 481-484 | 4 | |
| β-strand | 487-490 | 4 | 31 |
| α-helix | 493-499 | 7 | |
| β-strand | 506-513 | 8 | 32 |
| α-helix | 514-515 | 2 | |
| α-helix | 516-524 | 9 | |
| α-helix | 528-535 | 8 | |
| α-helix | 538-554 | 17 | |
| β-strand | 558-561 | 4 | 32 |
| α-helix | 565-575 | 11 | |
| β-strand | 579-580 | 2 | 32 |
| α-helix | 586-597 | 12 | |
| β-strand | 604-607 | 4 | 32 |
| β-strand | 623-625 | 3 | 32 |
| α-helix | 633-643 | 11 | |
| β-strand | 658-665 | 8 | 32 |
| α-helix | 670-683 | 14 | |
| β-strand | 686-690 | 5 | 32 |
| α-helix | 706-718 | 13 | |
Chain 7: 40 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-4 | 2 | 34 |
| β-strand | 9-10 | 2 | 34 |
| α-helix | 19-33 | 15 | |
| β-strand | 39 | 1 | 35 |
| β-strand | 40-41 | 2 | 36 |
| α-helix | 48-62 | 15 | |
| β-strand | 70-74 | 5 | 35 |
| α-helix | 77-97 | 21 | |
| β-strand | 106-108 | 3 | 35 |
| α-helix | 127-137 | 11 | |
| α-helix | 140-148 | 9 | |
| α-helix | 158-160 | 3 | |
| α-helix | 161-165 | 5 | |
| α-helix | 177-187 | 11 | |
| α-helix | 191-197 | 7 | |
| β-strand | 204-207 | 4 | 35 |
| α-helix | 209-213 | 5 | |
| α-helix | 223-228 | 6 | |
| β-strand | 230-234 | 5 | 35 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-247 | 9 | |
| β-strand | 250-252 | 3 | 37 |
| α-helix | 253-276 | 24 | |
| α-helix | 279-290 | 12 | |
| α-helix | 294-298 | 5 | |
| α-helix | 312-314 | 3 | |
| α-helix | 326-345 | 20 | |
| β-strand | 350-352 | 3 | 37 |
| α-helix | 354-364 | 11 | |
| α-helix | 369-373 | 5 | |
| α-helix | 375-386 | 12 | |
| α-helix | 391-409 | 19 | |
| β-strand | 415-419 | 5 | 37 |
| β-strand | 432-436 | 5 | 37 |
| α-helix | 440-443 | 4 | |
| α-helix | 445-450 | 6 | |
| β-strand | 453-456 | 4 | 35 |
| α-helix | 466-471 | 6 | |
| β-strand | 479-480 | 2 | 36 |
| β-strand | 490-494 | 5 | 38 |
| α-helix | 506-508 | 3 | |
| α-helix | 514-530 | 17 | |
| β-strand | 535-539 | 5 | 38 |
| α-helix | 542-554 | 13 | |
| α-helix | 558-564 | 7 | |
| β-strand | 566-567 | 2 | 38 |
| α-helix | 574-590 | 17 | |
| β-strand | 594-599 | 6 | 38 |
| α-helix | 603-607 | 5 | |
| α-helix | 609-611 | 3 | |
| β-strand | 617-620 | 4 | 38 |
| α-helix | 631-643 | 13 | |
| α-helix | 648-664 | 17 | |
| β-strand | 675-679 | 5 | 38 |
| α-helix | 682-686 | 5 | |
| α-helix | 688-692 | 5 | |
| α-helix | 695-700 | 6 | |
| α-helix | 710-725 | 16 | |
| α-helix | 727-728 | 2 | |
| α-helix | 730-733 | 4 | |
66 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Mediator of RNA polymerase II transcription subunit 1 | a | protein | 1581 | Homo sapiens | Q15648 (AlphaFold model) |
| Mediator of RNA polymerase II transcription subunit 31 | m | protein | 131 | Homo sapiens | Q9Y3C7 (AlphaFold model) |
| Mediator of RNA polymerase II transcription subunit 4 | d | protein | 270 | Homo sapiens | Q9NPJ6 (AlphaFold model) |
| Mediator of RNA polymerase II transcription subunit 6 | f | protein | 246 | Homo sapiens | O75586 (AlphaFold model) |
| Mediator of RNA polymerase II transcription subunit 7 | g | protein | 233 | Homo sapiens | O43513 |
| Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 | h | protein | 268 | Homo sapiens | Q96G25 |
| Mediator of RNA polymerase II transcription subunit 18 | r | protein | 208 | Homo sapiens | Q9BUE0 |
| Mediator of RNA polymerase II transcription subunit 20 | t | protein | 212 | Homo sapiens | Q9H944 |
| Mediator of RNA polymerase II transcription subunit 10 | j | protein | 135 | Homo sapiens | Q9BTT4 |
| Mediator of RNA polymerase II transcription subunit 11 | k | protein | 117 | Homo sapiens | Q9P086 |
| Mediator of RNA polymerase II transcription subunit 14 | n | protein | 1454 | Homo sapiens | O60244 |
| Mediator of RNA polymerase II transcription subunit 17 | q | protein | 651 | Homo sapiens | Q9NVC6 |
58 more molecules are not listed.
Sequence of entity 1 (a), FASTA
>7ENC_1 Mediator of RNA polymerase II transcription subunit 1 (chains a)
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SPDFMIGEEDDDLMDVALIGN
Sequence of entity 2 (m), FASTA
>7ENC_2 Mediator of RNA polymerase II transcription subunit 31 (chains m)
MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKD
PEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALA
EQQQQNNTSGK
Sequence of entity 3 (d), FASTA
>7ENC_3 Mediator of RNA polymerase II transcription subunit 4 (chains d)
MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAG
EENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQI
LATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDL
EMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDF
LLEPPGHNKENEDDVEIMSTDSSSSSSESD
Sequence of entity 4 (f), FASTA
>7ENC_4 Mediator of RNA polymerase II transcription subunit 6 (chains f)
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHL
NQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVL
TAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDAL
LLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPE
KRMRLQ
Sequence of entity 5 (g), FASTA
>7ENC_5 Mediator of RNA polymerase II transcription subunit 7 (chains g)
MGEPQQVSAALPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLE
SQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVH
HLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEA
GMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP
Sequence of entity 6 (h), FASTA
>7ENC_6 Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 (chains h)
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLN
KVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQ
EKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNA
LVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQ
MAQAGQPGKMPSGIKTNIKSASMHPYQR
Sequence of entity 7 (r), FASTA
>7ENC_7 Mediator of RNA polymerase II transcription subunit 18 (chains r)
MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLL
KGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLME
MGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQD
MVSDDMKNFAEQLKPLVHLEKIDPKRLM
Sequence of entity 8 (t), FASTA
>7ENC_8 Mediator of RNA polymerase II transcription subunit 20 (chains t)
MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTG
KLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYC
DFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRH
DAVYGPADTMVQYMELFNKIRKQQQVPVAGIR
Sequence of entity 9 (j), FASTA
>7ENC_9 Mediator of RNA polymerase II transcription subunit 10 (chains j)
MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHD
ITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPED
MAKYRSIRGEDHPPS
Sequence of entity 10 (k), FASTA
>7ENC_10 Mediator of RNA polymerase II transcription subunit 11 (chains k)
MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVE
AELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN
Sequence of entity 11 (n), FASTA
>7ENC_11 Mediator of RNA polymerase II transcription subunit 14 (chains n)
MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLH
RAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISS
FLDQQAILFVDTLDRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPP
DPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDD
PDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFC
LSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIK
IDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAIL
RGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEK
SVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFI
KLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVF
RTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLE
LSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTW
VAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECV
LEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGP
NSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTA
YQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLK
TFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYP
LTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGP
GASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPD
ASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAG
SYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQT
LQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIM
KLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEP
VSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVR
DLMANLTLPPGGRP
Sequence of entity 12 (q), FASTA
>7ENC_12 Mediator of RNA polymerase II transcription subunit 17 (chains q)
MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEA
AGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVR
DKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQ
RDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDY
CPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQN
VLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATE
KQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINS
LQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLIT
SQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQL
AKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQ
CKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 1 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ZN | Zinc ion | Zn | 16 |
Primary citation
Structures of the human Mediator and Mediator-bound preinitiation complex. Chen, X., Yin, X., Li, J. et al. Science (2021) 372. DOI 10.1126/science.abg0635 · PubMed
Other PDB entries of the same protein (UniProt Q15648 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9IWM 1.39 Å, X-ray structure of human PPARalpha ligand binding domain-GW7647-TRAP220 coactivator…
- 9VOG 1.43 Å, Vitamin D receptor complex with a 5-{4-(m-carboran-1-yl)phenoxy}-4-hydroxypentanoic acid…
- 9M1D 1.44 Å, Vitamin D receptor complex with a methyldiphenylpropylsilane derivative
- 9M1C 1.67 Å, Vitamin D receptor complex with a triphenylpropylsilane derivative
- 9M13 1.68 Å, Vitamin D receptor complex with a dimethyldiphenylsilane derivative
- 2O4J 1.74 Å, Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII…
- 9VOL 1.75 Å, Vitamin D receptor complex with a 4-{4-(m-carboran-1-yl)-2-methylphenoxy}butanoic acid…
- 9M1B 1.77 Å, Vitamin D receptor complex with a diphenydipropylsilane derivative
- 9M1A 1.78 Å, Vitamin D receptor complex with a diethyldiphenylsilane derivative
- 3W0H 1.8 Å, Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel…
- 6K5O 1.8 Å, Development of Novel Lithocholic Acid Derivatives as Vitamin D Receptor Agonists
- 3AUN 1.81 Å, Crystal structure of the rat vitamin D receptor ligand binding domain complexed with…
Browse structure collections
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