7ENJ: PDB entry 7ENJ

Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B). Determined by electron microscopy at 4.4 Å resolution. Released 19 May 2021.

Method
Electron microscopy
Resolution
4.4 Å
Organism
Homo sapiens
Chains
26
Atoms
57,971
Mol. weight
1303.86 kDa
Ligands
ZN
Released
19 May 2021

Explore 7ENJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ENJ contains 329 α-helices and 181 β-strands across 26 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 9 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix8-3730
α-helix45-7632
α-helix104-13027
α-helix159-17113
β-strand176-181648
β-strand189-194648
β-strand198-204748
β-strand209-216848
β-strand222149
β-strand228149
α-helix237-25216
α-helix260-27112
α-helix272-2754
α-helix279-2813
β-strand296-297250
β-strand304-305250
α-helix307-3093
Chain 1: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix44-5512
α-helix70-10536
α-helix108-14336
Chain 2: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix56-8934
α-helix102-13534
α-helix157-18529
Chain 3: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix30-5728
α-helix70-10132
β-strand117142
α-helix137-17539
Chain 4: 9 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix11-2818
α-helix31-399
α-helix46-549
α-helix55-595
α-helix61-644
α-helix72-798
α-helix83-864
α-helix91-10515
α-helix107-12115
Chain A: 19 helices, 19 β-strands
ElementResiduesLengthSheet
α-helix14-2613
α-helix34-4512
α-helix57-6610
α-helix67-693
α-helix74-8815
α-helix901
β-strand91-9441
β-strand100-10341
β-strand108-11141
α-helix136-1438
α-helix147-16014
α-helix168-19427
α-helix199-2046
β-strand210-21232
α-helix213-2142
β-strand21513
β-strand21813
β-strand220-22562
α-helix228-2314
β-strand253-26192
β-strand268-26924
β-strand296-29724
β-strand301-314142
α-helix315-32511
β-strand337-33822
α-helix339-34810
β-strand362-36655
β-strand371-37555
α-helix380-3823
β-strand389-398102
α-helix401-4033
α-helix404-42219
β-strand438-44695
β-strand449-45575
β-strand462-46985
β-strand475-48065
α-helix491-50111
α-helix504-51714
Chain B: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix6-1712
Chain D: 5 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix27-5125
α-helix63-14078
β-strand143-14426
α-helix145-15612
β-strand16917
β-strand17117
α-helix179-1835
α-helix186-1894

18 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Mediator of RNA polymerase II transcription subunit 1Aprotein1581Homo sapiensQ15648 (AlphaFold model)
Unknown ChainBprotein20Homo sapiens
Mediator of RNA polymerase II transcription subunit 4Dprotein270Homo sapiensQ9NPJ6 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 6Fprotein246Homo sapiensO75586 (AlphaFold model)
Mediator of RNA polymerase II transcription subunit 7Gprotein233Homo sapiensO43513 (AlphaFold model)
Isoform 2 of Mediator of RNA polymerase II transcription subunit 8Hprotein268Homo sapiensQ96G25
Mediator of RNA polymerase II transcription subunit 9Iprotein146Homo sapiensQ9NWA0
Mediator of RNA polymerase II transcription subunit 10Jprotein135Homo sapiensQ9BTT4
Mediator of RNA polymerase II transcription subunit 11Kprotein117Homo sapiensQ9P086
Mediator of RNA polymerase II transcription subunit 14Nprotein1454Homo sapiensO60244
Mediator of RNA polymerase II transcription subunit 15Oprotein788Homo sapiensQ96RN5
Mediator of RNA polymerase II transcription subunit 16Pprotein877Homo sapiensQ9Y2X0

14 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>7ENJ_1 Mediator of RNA polymerase II transcription subunit 1 (chains A)
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SPDFMIGEEDDDLMDVALIGN
Sequence of entity 2 (B), FASTA
>7ENJ_2 Unknown Chain (chains B)
XXXXXXXXXXXXXXXXXXXX
Sequence of entity 3 (D), FASTA
>7ENJ_3 Mediator of RNA polymerase II transcription subunit 4 (chains D)
MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAG
EENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQI
LATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDL
EMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDF
LLEPPGHNKENEDDVEIMSTDSSSSSSESD
Sequence of entity 4 (F), FASTA
>7ENJ_4 Mediator of RNA polymerase II transcription subunit 6 (chains F)
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHL
NQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVL
TAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDAL
LLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPE
KRMRLQ
Sequence of entity 5 (G), FASTA
>7ENJ_5 Mediator of RNA polymerase II transcription subunit 7 (chains G)
MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLE
SQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVH
HLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEA
GMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP
Sequence of entity 6 (H), FASTA
>7ENJ_6 Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 (chains H)
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLN
KVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQ
EKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNA
LVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQ
MAQAGQPGKMPSGIKTNIKSASMHPYQR
Sequence of entity 7 (I), FASTA
>7ENJ_7 Mediator of RNA polymerase II transcription subunit 9 (chains I)
MASAGVAAGRQAEDVLPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREE
ENYSFLPLVHNIIKCMDKDSPEVHQDLNALKSKFQEMRKLISTMPGIHLSPEQQQQQLQS
LREQVRTKNELLQKYKSLCMFEIPKE
Sequence of entity 8 (J), FASTA
>7ENJ_8 Mediator of RNA polymerase II transcription subunit 10 (chains J)
MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHD
ITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPED
MAKYRSIRGEDHPPS
Sequence of entity 9 (K), FASTA
>7ENJ_9 Mediator of RNA polymerase II transcription subunit 11 (chains K)
MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVE
AELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN
Sequence of entity 10 (N), FASTA
>7ENJ_10 Mediator of RNA polymerase II transcription subunit 14 (chains N)
MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLH
RAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISS
FLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPP
DPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDD
PDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFC
LSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIK
IDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAIL
RGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEK
SVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFI
KLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVF
RTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLE
LSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTW
VAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECV
LEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGP
NSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTA
YQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLK
TFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYP
LTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGP
GASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPD
ASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAG
SYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQT
LQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIM
KLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEP
VSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVR
DLMANLTLPPGGRP
Sequence of entity 11 (O), FASTA
>7ENJ_11 Mediator of RNA polymerase II transcription subunit 15 (chains O)
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
RLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMG
QPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQ
QQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQR
IAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQ
PPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQ
PQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQ
PMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSF
LPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLS
KYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMA
VPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVC
TRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPP
LELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSV
HQACLSAA
Sequence of entity 12 (P), FASTA
>7ENJ_12 Mediator of RNA polymerase II transcription subunit 16 (chains P)
MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEY
CMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCT
VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVT
SRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn1

Primary citation

Structures of the human Mediator and Mediator-bound preinitiation complex. Chen, X., Yin, X., Li, J. et al. Science (2021) 372. DOI 10.1126/science.abg0635 · PubMed

Other PDB entries of the same protein (UniProt Q15648 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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