7FCH: IL-18Rbeta TIR domain

IL-18Rbeta TIR domain. Determined by X-ray diffraction at 1.88 Å resolution. Released 20 Jul 2022.

Method
X-ray diffraction
Resolution
1.88 Å
Organism
Homo sapiens
Chains
4
Atoms
4,790
Mol. weight
76.31 kDa
Released
20 Jul 2022

Explore 7FCH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7FCH contains 45 α-helices and 20 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 5 β-strands

ElementResiduesLengthSheet
β-strand408-41361
α-helix430-4323
α-helix433-4375
α-helix4381
α-helix439-4457
β-strand450-45121
α-helix453-4564
α-helix463-47210
β-strand474-48181
α-helix483-4864
α-helix491-50111
β-strand508-51361
α-helix525-5339
β-strand536-53831
α-helix550-5589
Chain B: 12 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand408-41362
α-helix430-4323
α-helix433-4375
α-helix4381
α-helix439-4435
β-strand450-45122
α-helix453-4564
α-helix4581
α-helix463-47210
β-strand474-48182
α-helix483-4864
α-helix491-50313
β-strand508-51362
α-helix525-5339
β-strand536-53832
α-helix541-5444
α-helix550-5589
Chain C: 11 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand408-41363
α-helix430-4312
α-helix432-4376
α-helix4381
α-helix439-4457
β-strand450-45123
α-helix453-4564
α-helix463-47210
β-strand474-48183
α-helix483-4875
α-helix491-50313
β-strand508-51363
α-helix525-5339
β-strand536-53833
α-helix541-5433
α-helix550-5589
Chain D: 12 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand408-41364
α-helix430-4323
α-helix433-4375
α-helix4381
α-helix439-4435
β-strand450-45124
α-helix453-4564
α-helix4581
α-helix463-47210
β-strand474-48184
α-helix483-4875
α-helix491-50111
β-strand508-51364
α-helix525-5339
β-strand536-53834
α-helix541-5444
α-helix550-5589

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Interleukin-18 receptor accessory proteinA, B, C, Dprotein166Homo sapiensO95256 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>7FCH_1 Interleukin-18 receptor accessory protein (chains A, B, C, D)
MKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYA
EDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLP
HLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKLEHHHHHH

Primary citation

Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling. Zhou, J., Xiao, Y., Ren, Y. et al. iScience (2022) 25:104508. DOI 10.1016/j.isci.2022.104508

Other PDB entries of the same protein (UniProt O95256 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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