7JZQ: CFTR Associated Ligand (CAL) PDZ domain

CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALPMB. Determined by X-ray diffraction at 1.35 Å resolution. Released 6 Oct 2021.

Method: X-ray diffraction
Resolution: 1.35 Å
Organisms: Homo sapiens, synthetic construct
Chains: 2
Atoms: 854
Mol. weight: 10.66 kDa
Ligands: VU1
Released: 6 Oct 2021

Explore 7JZQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7JZQ contains 3 α-helices and 7 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	279-284	6	1
β-strand	293-298	6	1
α-helix	299-301	3
β-strand	303-310	8	1
α-helix	315-319	5
β-strand	327-331	5	1
β-strand	334-335	2	1
α-helix	341-350	10
β-strand	354-360	7	1

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	7-9	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Golgi-associated PDZ and coiled-coil motif-containing protein	A	protein	87	Homo sapiens	Q9HD26 (AlphaFold model)
LyCALPMB peptide core	C	protein	10	synthetic construct

Sequence of entity 1 (A), FASTA

>7JZQ_1 Golgi-associated PDZ and coiled-coil motif-containing protein (chains A)
GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN
LRDTKHKEAVTILSQQRGEIEFEVVYV

Sequence of entity 2 (C), FASTA

>7JZQ_2 LyCALPMB peptide core (chains C)
ANSRLPTSKI

Ligands and cofactors

ID	Name	Formula	Copies
VU1	4-[(piperidin-1-yl)methyl]benzoic acid	C13 H17 N O2	1

Primary citation

CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALPMB. Gill, N.P. To be published.

Other PDB entries of the same protein (UniProt Q9HD26 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4JOK 1.09 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide Y-iCAL36 (ANSRYPTSII)
4JOE 1.14 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide A-iCAL36 (ANSRAPTSII)
4JOF 1.2 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide L-iCAL36 (ANSRLPTSII)
4JOJ 1.2 Å, CFTR Associated Ligand (CAL) domain bound to peptide F-iCAL36 (ANSRFPTSII)
4NMP 1.3 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)
4JOR 1.34 Å, CFTR Associated Ligand (CAL) PDZ domain bound to HPV18 E6 oncoprotein C-terminal peptide…
5K4F 1.36 Å, CAL PDZ mutant C319A with a peptide
4E34 1.4 Å, Crystal structure of CFTR Associated Ligand (CAL) PDZ domain bound to iCAL36…
4E35 1.4 Å, Crystal structure of CFTR Associated Ligand (CAL) PDZ domain bound to iCAL36-L…
4NMO 1.4 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-1)(ANSRWPTS[Ac-K]I)
4NMQ 1.4 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-4) (ANSRW[Ac-K]TSII)
4NMT 1.4 Å, CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(TFA-K-1)…

Browse structure collections

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