7K04: TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening
Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening. Determined by electron microscopy at 9.25 Å resolution. Released 28 Jul 2021.
- Method
- Electron microscopy
- Resolution
- 9.25 Å
- Organisms
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c), synthetic construct
- Chains
- 11
- Atoms
- 27,945
- Mol. weight
- 540.96 kDa
- Ligands
- CA, SF4, ZN
- Released
- 28 Jul 2021
Explore 7K04 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7K04 contains 172 α-helices and 144 β-strands across 9 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 39 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-4 | 2 | 9 |
| β-strand | 9-10 | 2 | 9 |
| α-helix | 19-33 | 15 | |
| β-strand | 40-41 | 2 | 10 |
| α-helix | 48-62 | 15 | |
| β-strand | 69-71 | 3 | 10 |
| α-helix | 76-97 | 22 | |
| β-strand | 105-108 | 4 | 10 |
| α-helix | 118-122 | 5 | |
| α-helix | 126-136 | 11 | |
| α-helix | 141-147 | 7 | |
| α-helix | 158-161 | 4 | |
| α-helix | 162-166 | 5 | |
| α-helix | 178-187 | 10 | |
| α-helix | 192-199 | 8 | |
| β-strand | 205-208 | 4 | 10 |
| α-helix | 211-214 | 4 | |
| β-strand | 231-235 | 5 | 10 |
| α-helix | 241-248 | 8 | |
| β-strand | 250 | 1 | 11 |
| β-strand | 253 | 1 | 12 |
| α-helix | 254-277 | 24 | |
| α-helix | 280-291 | 12 | |
| α-helix | 295-298 | 4 | |
| α-helix | 323-326 | 4 | |
| α-helix | 328-346 | 19 | |
| β-strand | 352 | 1 | 13 |
| α-helix | 356-366 | 11 | |
| α-helix | 371-375 | 5 | |
| α-helix | 377-388 | 12 | |
| α-helix | 394-396 | 3 | |
| α-helix | 397-411 | 15 | |
| β-strand | 416-418 | 3 | 11 |
| β-strand | 420 | 1 | 13 |
| β-strand | 421 | 1 | 12 |
| α-helix | 425-427 | 3 | |
| β-strand | 434 | 1 | 12 |
| β-strand | 437-439 | 3 | 11 |
| α-helix | 443-452 | 10 | |
| β-strand | 456-460 | 5 | 10 |
| α-helix | 468-473 | 6 | |
| β-strand | 481-482 | 2 | 10 |
| β-strand | 494 | 1 | 14 |
| β-strand | 499 | 1 | 15 |
| β-strand | 505 | 1 | 15 |
| α-helix | 516-532 | 17 | |
| β-strand | 537-541 | 5 | 16 |
| α-helix | 544-556 | 13 | |
| α-helix | 559-566 | 8 | |
| β-strand | 568-571 | 4 | 16 |
| α-helix | 576-591 | 16 | |
| β-strand | 596-601 | 6 | 16 |
| α-helix | 605-609 | 5 | |
| β-strand | 619 | 1 | 16 |
| β-strand | 620 | 1 | 14 |
| β-strand | 623 | 1 | 17 |
| α-helix | 634-645 | 12 | |
| α-helix | 650-666 | 17 | |
| α-helix | 667-669 | 3 | |
| β-strand | 679 | 1 | 14 |
| β-strand | 682 | 1 | 17 |
| α-helix | 686-689 | 4 | |
| α-helix | 695-700 | 6 | |
| α-helix | 703-705 | 3 | |
| β-strand | 709 | 1 | 15 |
| α-helix | 710-725 | 16 | |
| α-helix | 734-737 | 4 | |
| α-helix | 744-751 | 8 | |
Chain 1: 18 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9 | 1 | 18 |
| β-strand | 12 | 1 | 18 |
| β-strand | 14-19 | 6 | 19 |
| β-strand | 26-31 | 6 | 19 |
| β-strand | 37-41 | 5 | 19 |
| β-strand | 47-50 | 4 | 20 |
| β-strand | 60-63 | 4 | 20 |
| β-strand | 72-73 | 2 | 21 |
| β-strand | 79-80 | 2 | 21 |
| β-strand | 86-88 | 3 | 20 |
| α-helix | 94-119 | 26 | |
| α-helix | 171-176 | 6 | |
| α-helix | 178-187 | 10 | |
| α-helix | 189-197 | 9 | |
| α-helix | 206-224 | 19 | |
| α-helix | 227-229 | 3 | |
| α-helix | 231-236 | 6 | |
| α-helix | 252-262 | 11 | |
| α-helix | 264-272 | 9 | |
| α-helix | 282-294 | 13 | |
| α-helix | 310-329 | 20 | |
| α-helix | 339-342 | 4 | |
| α-helix | 372-390 | 19 | |
| α-helix | 468-482 | 15 | |
| α-helix | 497-515 | 19 | |
| α-helix | 541-564 | 24 | |
| α-helix | 576-604 | 29 | |
| α-helix | 607-638 | 32 | |
Chain 2: 22 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-16 | 7 | |
| α-helix | 19-26 | 8 | |
| α-helix | 29-36 | 8 | |
| α-helix | 41-50 | 10 | |
| β-strand | 57-58 | 2 | 2 |
| α-helix | 59-65 | 7 | |
| α-helix | 71-83 | 13 | |
| β-strand | 87 | 1 | 3 |
| β-strand | 97-98 | 2 | 2 |
| β-strand | 100 | 1 | 3 |
| α-helix | 102-112 | 11 | |
| α-helix | 120-122 | 3 | |
| β-strand | 124 | 1 | 4 |
| α-helix | 136-151 | 16 | |
| α-helix | 161-169 | 9 | |
| α-helix | 186-193 | 8 | |
| α-helix | 197-210 | 14 | |
| α-helix | 218-230 | 13 | |
| β-strand | 234 | 1 | 4 |
| α-helix | 244-255 | 12 | |
| α-helix | 273-280 | 8 | |
| α-helix | 354-361 | 8 | |
| β-strand | 369 | 1 | 5 |
| β-strand | 374 | 1 | 5 |
| α-helix | 380-388 | 9 | |
| α-helix | 395-402 | 8 | |
| α-helix | 405-416 | 12 | |
| α-helix | 435-448 | 14 | |
| β-strand | 453-454 | 2 | 6 |
| β-strand | 457-459 | 3 | 7 |
| α-helix | 465-478 | 14 | |
| β-strand | 485 | 1 | 8 |
| β-strand | 490 | 1 | 8 |
| β-strand | 491-493 | 3 | 7 |
| α-helix | 496-506 | 11 | |
Chain 4: 10 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26-29 | 4 | 22 |
| β-strand | 30 | 1 | 23 |
| α-helix | 34-42 | 9 | |
| α-helix | 51-67 | 17 | |
| β-strand | 73-76 | 4 | 22 |
| β-strand | 79 | 1 | 24 |
| β-strand | 82 | 1 | 24 |
| β-strand | 85 | 1 | 22 |
| α-helix | 117-134 | 18 | |
| α-helix | 138-142 | 5 | |
| α-helix | 149-166 | 18 | |
| β-strand | 175-176 | 2 | 22 |
| β-strand | 179-182 | 4 | 23 |
| α-helix | 193-206 | 14 | |
| β-strand | 210 | 1 | 22 |
| β-strand | 212-216 | 5 | 23 |
| α-helix | 222-230 | 9 | |
| β-strand | 235-238 | 4 | 23 |
| α-helix | 245-251 | 7 | |
| β-strand | 275 | 1 | 25 |
| β-strand | 282 | 1 | 25 |
| α-helix | 283 | 1 | |
| β-strand | 287-288 | 2 | 26 |
| β-strand | 295-296 | 2 | 26 |
| α-helix | 314-321 | 8 | |
Chain 5: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-6 | 2 | 7 |
| β-strand | 8-11 | 4 | 6 |
| α-helix | 14-26 | 13 | |
| β-strand | 33 | 1 | 6 |
| β-strand | 39-42 | 4 | 6 |
| α-helix | 47-61 | 15 | |
Chain 6: 13 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 125-129 | 5 | 27 |
| α-helix | 134-137 | 4 | |
| α-helix | 145-163 | 19 | |
| β-strand | 168-172 | 5 | 27 |
| β-strand | 175 | 1 | 28 |
| β-strand | 178 | 1 | 28 |
| β-strand | 181-186 | 6 | 27 |
| α-helix | 189-200 | 12 | |
| α-helix | 210-220 | 11 | |
| β-strand | 230-234 | 5 | 27 |
| α-helix | 247-256 | 10 | |
| β-strand | 261-263 | 3 | 27 |
| α-helix | 271-280 | 10 | |
| α-helix | 294-305 | 12 | |
| β-strand | 320 | 1 | 26 |
| β-strand | 322-323 | 2 | 29 |
| β-strand | 347-348 | 2 | 30 |
| β-strand | 355-356 | 2 | 30 |
| β-strand | 362 | 1 | 29 |
| β-strand | 369-370 | 2 | 29 |
| α-helix | 374-383 | 10 | |
| α-helix | 386-389 | 4 | |
| β-strand | 390 | 1 | 31 |
| α-helix | 391-393 | 3 | |
| α-helix | 419-422 | 4 | |
| β-strand | 428 | 1 | 31 |
| α-helix | 438-446 | 9 | |
| α-helix | 452-455 | 4 | |
Chain 7: 32 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 105-108 | 4 | |
| α-helix | 122-124 | 3 | |
| α-helix | 125-127 | 3 | |
| β-strand | 132 | 1 | 40 |
| β-strand | 133-135 | 3 | 41 |
| β-strand | 140-142 | 3 | 41 |
| α-helix | 150-160 | 11 | |
| β-strand | 162 | 1 | 42 |
| β-strand | 174 | 1 | 42 |
| α-helix | 177-186 | 10 | |
| α-helix | 190-200 | 11 | |
| β-strand | 201 | 1 | 40 |
| α-helix | 204-206 | 3 | |
| α-helix | 207-218 | 12 | |
| β-strand | 223 | 1 | 43 |
| β-strand | 233 | 1 | 44 |
| α-helix | 239-247 | 9 | |
| β-strand | 255 | 1 | 45 |
| α-helix | 263-267 | 5 | |
| β-strand | 317 | 1 | 44 |
| β-strand | 318 | 1 | 45 |
| α-helix | 323-332 | 10 | |
| β-strand | 337 | 1 | 43 |
| α-helix | 344-346 | 3 | |
| α-helix | 350-352 | 3 | |
| β-strand | 353 | 1 | 46 |
| α-helix | 364-374 | 11 | |
| β-strand | 382-385 | 4 | 47 |
| α-helix | 392-403 | 12 | |
| β-strand | 407-411 | 5 | 48 |
| α-helix | 414-420 | 7 | |
| α-helix | 421-425 | 5 | |
| β-strand | 437 | 1 | 48 |
| β-strand | 451 | 1 | 46 |
| β-strand | 453-456 | 4 | 48 |
| α-helix | 457-460 | 4 | |
| α-helix | 469-479 | 11 | |
| β-strand | 484-487 | 4 | 48 |
| β-strand | 488 | 1 | 47 |
| α-helix | 495-505 | 11 | |
| β-strand | 511-514 | 4 | 47 |
| α-helix | 527-531 | 5 | |
| β-strand | 534 | 1 | 47 |
| α-helix | 540-543 | 4 | |
| β-strand | 553-554 | 2 | 49 |
| β-strand | 557-559 | 3 | 50 |
| α-helix | 563-570 | 8 | |
| α-helix | 578-582 | 5 | |
| α-helix | 585-600 | 16 | |
| β-strand | 605-608 | 4 | 49 |
| α-helix | 613-620 | 8 | |
| β-strand | 626-627 | 2 | 49 |
| α-helix | 633-643 | 11 | |
| β-strand | 651-654 | 4 | 49 |
| α-helix | 657-660 | 4 | |
| β-strand | 669-672 | 4 | 49 |
| α-helix | 680-693 | 14 | |
| β-strand | 704-707 | 4 | 49 |
| β-strand | 708-710 | 3 | 50 |
| α-helix | 716-728 | 13 | |
| β-strand | 733 | 1 | 49 |
| β-strand | 736 | 1 | 50 |
| α-helix | 742-744 | 3 | |
| α-helix | 753-769 | 17 | |
Chain A: 32 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 91-94 | 4 | |
| β-strand | 96-98 | 3 | 20 |
| α-helix | 134-162 | 29 | |
| α-helix | 165-172 | 8 | |
| α-helix | 177-183 | 7 | |
| α-helix | 185-187 | 3 | |
| α-helix | 192-214 | 23 | |
| β-strand | 216-217 | 2 | 32 |
| α-helix | 218-220 | 3 | |
| α-helix | 227-229 | 3 | |
| α-helix | 230-238 | 9 | |
| α-helix | 248-257 | 10 | |
| β-strand | 259-260 | 2 | 32 |
| α-helix | 262-275 | 14 | |
| β-strand | 280-286 | 7 | 33 |
| α-helix | 305-309 | 5 | |
| β-strand | 315-321 | 7 | 33 |
| β-strand | 326-331 | 6 | 33 |
| β-strand | 337-339 | 3 | 33 |
| α-helix | 354-356 | 3 | |
| β-strand | 362-366 | 5 | 33 |
| β-strand | 372-374 | 3 | 33 |
| α-helix | 376-379 | 4 | |
| α-helix | 387-390 | 4 | |
| α-helix | 392-394 | 3 | |
| α-helix | 396-409 | 14 | |
| α-helix | 416-432 | 17 | |
| α-helix | 439-441 | 3 | |
| β-strand | 447-449 | 3 | 34 |
| α-helix | 450-452 | 3 | |
| β-strand | 457-459 | 3 | 35 |
| α-helix | 460 | 1 | |
| β-strand | 467-470 | 4 | 34 |
| β-strand | 478-483 | 6 | 34 |
| α-helix | 484-486 | 3 | |
| β-strand | 487-489 | 3 | 35 |
| β-strand | 491 | 1 | 36 |
| α-helix | 493-498 | 6 | |
| β-strand | 501-503 | 3 | 37 |
| α-helix | 504 | 1 | |
| β-strand | 511-513 | 3 | 38 |
| β-strand | 529-531 | 3 | 38 |
| β-strand | 532 | 1 | 36 |
| α-helix | 534-536 | 3 | |
| β-strand | 537-539 | 3 | 37 |
| α-helix | 542-546 | 5 | |
| α-helix | 550-552 | 3 | |
| β-strand | 559-560 | 2 | 39 |
| α-helix | 564-566 | 3 | |
| β-strand | 571-575 | 5 | 39 |
| α-helix | 579-586 | 8 | |
| β-strand | 590-599 | 10 | 39 |
| β-strand | 605-615 | 11 | 39 |
| α-helix | 616-618 | 3 | |
| α-helix | 619-627 | 9 | |
| α-helix | 649-663 | 15 | |
1 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA repair protein RAD33 | E | protein | 177 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q04231 (AlphaFold model) |
| General transcription and DNA repair factor IIH subunit TFB2 | 2 | protein | 513 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q02939 (AlphaFold model) |
| DNA repair helicase RAD3 | 0 | protein | 778 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P06839 (AlphaFold model) |
| General transcription and DNA repair factor IIH subunit TFB1 | 1 | protein | 642 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32776 (AlphaFold model) |
| General transcription and DNA repair factor IIH subunit TFB4 | 4 | protein | 338 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q12004 |
| General transcription and DNA repair factor IIH subunit SSL1 | 6 | protein | 461 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q04673 |
| Damaged DNA strand | Y | DNA | 27 | synthetic construct | |
| Undamaged DNA strand | W | DNA | 29 | synthetic construct | |
| DNA repair protein RAD4 | A | protein | 754 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P14736 |
| DNA repair helicase RAD25 | 7 | protein | 843 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q00578 |
| RNA polymerase II transcription factor B subunit 5 | 5 | protein | 72 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q3E7C1 |
Sequence of entity 1 (E), FASTA
>7K04_1 DNA repair protein RAD33 (chains E)
MSKSTNVSYERVELFENPKVPIEVEDEILEKYAESSLDHDMTVNELPRFFKDLQLEPTIW
KLVRNEDVIIEGTDVIDFTKLVRCTCQLLILMNNLTVIDDLWSMLIRNCGRDVDFPQVAL
RDHVLSVKDLQKISNLIGADQSSGTIEMISCATDGKRLFMTYLDFGCVLGKLGYLKM
Sequence of entity 2 (2), FASTA
>7K04_2 General transcription and DNA repair factor IIH subunit TFB2 (chains 2)
MSDYSLKHSVTQYLEEIPQQVQNRLYTSPATCLAIYRILPPLAKFFIMAMVFNENEVPLL
DLDKWVNSNGKLQFQNAIKSMKSLHLLIPNKSSGTLMINLNPTFKISLRNALTGGEVQNS
FGVVVEENVVSLDLLDEYSANKWETILHFMVGTPLAKIPSEKVLNLLKHSKLMEEVNSTG
EFKITNEGFQFLLQEINSQLWTLLLQYLKMIETSKMDLVDVLHFIFMLGALEVGKAYKID
ALSETQRIMLQDMRDYGLVFQKHSNDSIFYPTKLALMLTSDTKTIRSASNAMDSVLRQNR
EEPSVNEDGANGKSTTDITTSDDLNKAGLKNQDIPDGSLIVETNFKIYSYSNSPLQIAVL
SLFVHLKARFVNMVLGQITRESIRRALTNGITADQIIAYLETHAHPQMRRLAEEKLEKKL
ELDPNCKEPLQVLPPTVVDQIRLWQLELDRVITYEGSLYSDFETSQEYNLLSKYAQDIGV
LLWKDDKKKKFFISKEGNSQVLDFAKRKLKKKQ
Sequence of entity 3 (0), FASTA
>7K04_3 DNA repair helicase RAD3 (chains 0)
MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQ
MHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEV
SKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEK
LLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNI
DNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILT
DQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFL
QHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLII
EPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQ
KSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVF
FPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLS
VARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMR
HAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLPKWIAQGLSDADLNLSTDMAISNTKQF
LRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKDQGGFIENENKEGEQDEDEDEDIEMQ
Sequence of entity 4 (1), FASTA
>7K04_4 General transcription and DNA repair factor IIH subunit TFB1 (chains 1)
PSHSGAAIFEKVSGIIAINEDVSPAELTWRSTDGDKVHTVVLSTIDKLQATPASSEKMML
RLIGKVDESKKRKDNEGNEVVPKPQRHMFSFNNRTVMDNIKMTLQQIISRYKDADIYEEK
RRREESAQHTETPMSSSSVTAGTPTPHLDTPQLNNGAPLINTAKLDDSLSKEKLLTNLKL
QQSLLKGNKVLMKVFQETVINAGLPPSEFWSTRIPLLRAFALSTSQKVGPYNVLSTIKPV
ASSENKVNVNLSREKILNIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLRGEK
IMQNDRGDVIIDRYLTLDQEFDRKDDDMLLHPVKKIIDLDGNIQDDPVVRGNRPDFTMQP
GVDINGNSDGTVDILKGMNRLSEKMIMALKNEYSRTNLQNKSNITNDEEDEDNDERNELK
IDDLNESYKTNYAIIHLKRNAHEKTTDNDAKSSADSIKNADLKVSNQQMLQQLSLVMDNL
INKLDLNQVVPNNEVSNKINKRVITAIKINAKQAKHNNVNSALGSFVDNTSQANELEVKS
TLPIDLLESCRMLHTTCCEFLKHFYIHFQSGEQKQASTVKKLYNHLKDCIEKLNELFQDV
LNGDGESMSNTCTAYLKPVLNSITLATHKYDEYFNEYNNNSN
Sequence of entity 5 (4), FASTA
>7K04_5 General transcription and DNA repair factor IIH subunit TFB4 (chains 4)
MDAISDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVF
LNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENKTRSDLKIINSDMYRRFRN
VDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLLVLT
CGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVYLHVES
TEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSCYLTGRVVAVGFICSVCLCVLSIIP
PGNKCPACDSQFDEHVIAKLKRKPVVPRLKAKKKVTKP
Sequence of entity 6 (6), FASTA
>7K04_6 General transcription and DNA repair factor IIH subunit SSL1 (chains 6)
MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKK
RLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQR
GIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQ
LVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLS
TTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKEL
FNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLP
TVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGK
LLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT
Sequence of entity 7 (Y), FASTA
>7K04_7 Damaged DNA strand (chains Y)
TATCTCGCAATGXTGGATGTTGAGTCA
Sequence of entity 8 (W), FASTA
>7K04_8 Undamaged DNA strand (chains W)
TTGACTCAACATCCAAACACTGCGAGATA
Sequence of entity 9 (A), FASTA
>7K04_9 DNA repair protein RAD4 (chains A)
MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKKKFKTGLNELPRESVV
TVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTDGNEVAGVEDISVEIKPSSKR
NSDARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWINSKRLSRKLSNLVPEKVF
ELLHPQKDEELPLRSTRKLLDGLKKCMELWQKHWKITKKYDNEGLYMRTWKEIEMSANNK
RKFKTLKRSDFLRAVSKGHGDPDISVQGFVAMLRACNVNARLIMSCQPPDFTNMKIDTSL
NGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPKGVACCERNML
RYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEKWFRKVITALHHRKRTKIDDY
EDQYFFRRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPGCKECGYLKVHGKVGKVLK
VYAKRDIADLKSARQWYMNGRILKTGSRCKKVIKRTVGRPKGEAEEEDERLYSFEDTELY
IPPLASASGEITKNTFGNIEVFAPTMIPGNCCLVENPVAIKAARFLGVEFAPAVTSFKFE
RGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWNTLLLKLRIRS
KLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMGGGFLPGIANHEARPYSEPSEPEDSLD
YVSVDKAEESATDDDVGEDYSDFMKELEMSEESD
Sequence of entity 10 (7), FASTA
>7K04_10 DNA repair helicase RAD25 (chains 7)
MTDVEGYQPKSKGKIFPDMGESFFSSDEDSPATDAEIDENYDDNRETSEGRGERDTGAMV
TGLKKPRKKTKSSRHTAADSSMNQMDAKDKALLQDTNSDIPADFVPDSVSGMFRSHDFSY
LRLRPDHASRPLWISPSDGRIILESFSPLAEQAQDFLVTIAEPISRPSHIHEYKITAYSL
YAAVSVGLETDDIISVLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQAD
ILQMLLNDSVIGPLRIDSDHQVQPPEDVLQQQLQQTAGKPATNVNPNDVEAVFSAVIGGD
NEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPST
QIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQW
RQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGR
EWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEANW
MELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHER
RGDKIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDT
SIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYST
KRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDAD
NSVGRGSNGHKRFKSKAVRGEGSLSGLAGGEDMAYMEYSTNKNKELKEHHPLIRKMYYKN
LKK
Sequence of entity 11 (5), FASTA
>7K04_11 RNA polymerase II transcription factor B subunit 5 (chains 5)
MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSK
NIYNPMDEEENQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CA | Calcium ion | Ca | 2 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ZN | Zinc ion | Zn | 5 |
Primary citation
Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. van Eeuwen, T., Shim, Y., Kim, H.J. et al. Nat Commun (2021) 12:3338-3338. DOI 10.1038/s41467-021-23684-x · PubMed
Other PDB entries of the same protein (UniProt Q04231 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7M2U 8.2 Å, Nucleotide Excision Repair complex TFIIH Rad4-33
Browse structure collections
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