7LT3: NHEJ Long-range synaptic complex

NHEJ Long-range synaptic complex. Determined by electron microscopy at 4.6 Å resolution. Released 14 Apr 2021.

Method: Electron microscopy
Resolution: 4.6 Å
Organism: Homo sapiens
Chains: 20
Atoms: 93,244
Mol. weight: 1715 kDa
Ligands: ADP
Released: 14 Apr 2021

Explore 7LT3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7LT3 contains 648 α-helices and 246 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and J: 19 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	35-43	9	1
α-helix	46-49	4
α-helix	59-77	19
β-strand	82-88	7	1
β-strand	94	1	1
β-strand	102-109	8	1
β-strand	112	1	2
α-helix	113-120	8
α-helix	125-134	10
α-helix	143-156	14
β-strand	161-169	9	1
α-helix	180-195	16
β-strand	199-202	4	1
α-helix	238-241	4
β-strand	257-262	6	3
β-strand	268-273	6	3
β-strand	274-275	2	4
β-strand	277	1	5
α-helix	280-285	6
β-strand	286-289	4	6
β-strand	295	1	6
β-strand	298	1	7
β-strand	303-304	2	8
β-strand	310	1	8
α-helix	313-315	3
β-strand	316-322	7	9
β-strand	325-329	5	9
α-helix	333-336	4
β-strand	344-351	8	3
α-helix	358-360	3
β-strand	366-368	3	4
β-strand	370	1	3
α-helix	378-392	15
β-strand	395-401	7	3
β-strand	409-412	4	3
β-strand	415-416	2	4
β-strand	419	1	10
β-strand	428	1	10
β-strand	431-434	4	4
β-strand	435-437	3	3
α-helix	438	1
α-helix	440-442	3
α-helix	453-455	3
α-helix	456-468	13
β-strand	470	1	11
α-helix	481-495	15
α-helix	511-517	7
α-helix	521-529	9

Chains B and K: 24 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	12
α-helix	19-21	3
α-helix	30-47	18
β-strand	53-59	7	12
β-strand	65	1	13
β-strand	78	1	13
β-strand	79-84	6	12
α-helix	88-97	10
α-helix	107-121	15
β-strand	129-135	7	12
α-helix	147-156	10
β-strand	159-164	6	12
α-helix	199-215	17
α-helix	218-221	4
β-strand	224-225	2	12
α-helix	228-234	7
α-helix	237-239	3
β-strand	247-252	6	11
β-strand	259-267	9	11
β-strand	277-280	4	9
α-helix	286-288	3
β-strand	289-290	2	8
β-strand	295-296	2	7
α-helix	302	1
β-strand	303-304	2	7
α-helix	305	1
β-strand	310-316	7	6
β-strand	317	1	2
β-strand	319-322	4	6
α-helix	326-331	6
β-strand	341-347	7	11
β-strand	361-366	6	11
α-helix	367	1
α-helix	371-386	16
β-strand	389-395	7	11
β-strand	404-413	10	11
β-strand	416-423	8	11
α-helix	427-429	3
β-strand	430	1	5
α-helix	448-460	13
β-strand	462	1	3
α-helix	483-484	2
α-helix	485-499	15
α-helix	510-516	7
α-helix	518-519	2
α-helix	520-534	15
α-helix	548-550	3
α-helix	726-730	5

Chain C: 241 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	8-19	12
α-helix	24-44	21
α-helix	50-58	9
α-helix	65-71	7
α-helix	79-95	17
α-helix	101-103	3
α-helix	104-117	14
α-helix	121-137	17
α-helix	142-147	6
α-helix	149-159	11
α-helix	168-184	17
α-helix	186-189	4
α-helix	193-208	16
α-helix	214-215	2
α-helix	217-231	15
α-helix	241-245	5
α-helix	246-256	11
α-helix	266-300	35
α-helix	306-327	22
α-helix	334-337	4
α-helix	341-351	11
α-helix	356-368	13
α-helix	370-376	7
α-helix	379-396	18
α-helix	409-421	13
α-helix	432-445	14
α-helix	446-448	3
α-helix	451-470	20
α-helix	473-491	19
α-helix	524-527	4
α-helix	528-536	9
α-helix	539-542	4
α-helix	558-578	21
α-helix	617-633	17
α-helix	635-637	3
α-helix	640-645	6
α-helix	646-659	14
α-helix	665-679	15
α-helix	683-685	3
α-helix	700-720	21
α-helix	723-733	11
α-helix	738-741	4
α-helix	749-759	11
α-helix	763-779	17
α-helix	782-785	4
α-helix	786-788	3
α-helix	789-792	4
α-helix	798-800	3
α-helix	817-824	8
α-helix	828-837	10
α-helix	848-861	14
α-helix	864-867	4
α-helix	868-870	3
α-helix	878-882	5
β-strand	884	1	14
β-strand	893-894	2	15
β-strand	905-906	2	15
α-helix	907-909	3
α-helix	911-920	10
α-helix	924-946	23
α-helix	956	1
α-helix	959-972	14
α-helix	978-994	17
α-helix	1004-1017	14
α-helix	1023-1043	21
α-helix	1046-1049	4
α-helix	1056-1067	12
α-helix	1072-1083	12
α-helix	1086-1091	6
α-helix	1093-1096	4
α-helix	1097-1110	14
α-helix	1124-1139	16
α-helix	1165-1174	10
α-helix	1181-1194	14
α-helix	1195-1197	3
α-helix	1204-1224	21
α-helix	1237-1242	6
α-helix	1253-1267	15
α-helix	1278-1281	4
α-helix	1289-1292	4
α-helix	1293-1301	9
α-helix	1324-1348	25
α-helix	1355-1361	7
α-helix	1366-1377	12
α-helix	1379-1381	3
α-helix	1384-1386	3
α-helix	1389-1408	20
α-helix	1412-1418	7
α-helix	1420-1423	4
α-helix	1426-1433	8
α-helix	1441-1461	21
α-helix	1464-1467	4
α-helix	1469-1470	2
α-helix	1477-1483	7
α-helix	1484-1488	5
α-helix	1489-1491	3
α-helix	1505-1519	15
α-helix	1525-1532	8
β-strand	1537-1538	2	16
β-strand	1553-1554	2	16
α-helix	1555-1562	8
α-helix	1564-1573	10
α-helix	1575-1584	10
α-helix	1590-1606	17
α-helix	1615-1624	10
α-helix	1626-1631	6
α-helix	1639-1656	18
α-helix	1668-1680	13
α-helix	1686-1692	7
α-helix	1707-1721	15
α-helix	1734-1753	20
α-helix	1756-1766	11
β-strand	1767	1	17
β-strand	1769	1	17
α-helix	1776-1786	11
α-helix	1791-1806	16
α-helix	1813-1818	6
α-helix	1819-1825	7
α-helix	1826-1829	4
α-helix	1832	1
α-helix	1836-1852	17
α-helix	1863-1881	19
α-helix	1886-1889	4
β-strand	1893	1	18
β-strand	1907	1	18
α-helix	1914-1923	10
α-helix	1934-1954	21
α-helix	1959-1962	4
α-helix	1975-1978	4
α-helix	2094-2105	12
α-helix	2121-2127	7
α-helix	2128-2132	5
α-helix	2140-2152	13
α-helix	2154-2157	4
α-helix	2165-2173	9
α-helix	2184-2200	17
α-helix	2206-2222	17
α-helix	2230-2244	15
α-helix	2253-2260	8
α-helix	2270-2284	15
α-helix	2296-2305	10
α-helix	2306-2308	3
α-helix	2313-2332	20
α-helix	2337-2353	17
α-helix	2357-2368	12
α-helix	2374-2384	11
α-helix	2392-2404	13
α-helix	2411-2417	7
α-helix	2420-2424	5
α-helix	2429-2441	13
α-helix	2448-2458	11
α-helix	2459-2462	4
α-helix	2467-2484	18
α-helix	2493-2508	16
α-helix	2509-2511	3
α-helix	2515-2526	12
α-helix	2535-2542	8
α-helix	2543-2545	3
α-helix	2548-2550	3
α-helix	2551-2566	16
β-strand	2575	1	19
β-strand	2586-2588	3	20
α-helix	2724-2728	5
α-helix	2736-2767	32
β-strand	2776-2778	3	20
β-strand	2786	1	19
α-helix	2788-2800	13
α-helix	2802-2819	18
α-helix	2820-2822	3
α-helix	2826-2846	21
α-helix	2852-2863	12
α-helix	2873-2882	10
α-helix	2886-2900	15
α-helix	2920-2932	13
α-helix	2936-2943	8
α-helix	2951-2961	11
α-helix	2965-2976	12
α-helix	2985-2987	3
α-helix	2988-3003	16
α-helix	3008-3017	10
α-helix	3027-3031	5
α-helix	3034-3035	2
α-helix	3036-3040	5
α-helix	3041-3053	13
α-helix	3060-3068	9
α-helix	3072-3081	10
α-helix	3083-3092	10
α-helix	3096-3115	20
α-helix	3122-3129	8
α-helix	3132-3144	13
α-helix	3149-3152	4
α-helix	3155-3165	11
α-helix	3176-3196	21
α-helix	3228-3248	21
α-helix	3252-3262	11
α-helix	3263-3265	3
α-helix	3270-3290	21
α-helix	3296-3297	2
α-helix	3298-3305	8
α-helix	3306-3307	2
α-helix	3310-3312	3
α-helix	3315-3318	4
α-helix	3321-3343	23
α-helix	3345-3347	3
α-helix	3355-3363	9
α-helix	3372-3392	21
α-helix	3409-3427	19
α-helix	3433-3439	7
α-helix	3441-3445	5
α-helix	3446-3451	6
α-helix	3452-3454	3
α-helix	3459-3463	5
α-helix	3465-3474	10
α-helix	3479-3482	4
α-helix	3483-3487	5
α-helix	3493-3496	4
α-helix	3499-3505	7
α-helix	3509-3512	4
α-helix	3515-3524	10
α-helix	3526-3537	12
α-helix	3546-3561	16
α-helix	3564-3566	3
α-helix	3567-3577	11
α-helix	3584-3596	13
α-helix	3600-3602	3
α-helix	3603-3613	11
α-helix	3614-3618	5
α-helix	3627-3635	9
α-helix	3638-3642	5
α-helix	3646-3652	7
α-helix	3660-3671	12
α-helix	3676-3678	3
α-helix	3681-3683	3
α-helix	3685-3688	4
α-helix	3697-3699	3
β-strand	3700	1	21
β-strand	3718	1	21
β-strand	3719-3722	4	22
β-strand	3727-3728	2	23
β-strand	3736-3737	2	23
β-strand	3739-3742	4	22
β-strand	3747-3749	3	22
β-strand	3753-3754	2	24
α-helix	3759-3777	19
α-helix	3779-3783	5
α-helix	3788-3790	3
β-strand	3793-3797	5	24
β-strand	3800-3803	4	24
β-strand	3810-3811	2	25
α-helix	3812-3819	8
α-helix	3822-3829	8
α-helix	3839-3845	7
α-helix	3855-3861	7
α-helix	3866-3877	12
α-helix	3882-3890	9
β-strand	3891	1	14
α-helix	3894-3917	24
β-strand	3928-3930	3	25
β-strand	3937-3939	3	25
α-helix	3965-3970	6
α-helix	3979-3991	13
α-helix	3995-3997	3
α-helix	3999-4001	3
α-helix	4040-4052	13
β-strand	4054	1	26
α-helix	4056-4067	12
α-helix	4074-4082	9
β-strand	4096	1	26
α-helix	4100-4112	13
α-helix	4114-4118	5

Chain F: 5 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2-8	7	27
β-strand	10	1	28
α-helix	16-17	2
β-strand	18-24	7	27
α-helix	28-30	3
β-strand	31-37	7	27
β-strand	42-48	7	27
α-helix	49-59	11
α-helix	65-74	10
β-strand	84-88	5	28
β-strand	94-101	8	28
β-strand	104-112	9	28
β-strand	114-115	2	27
α-helix	119-200	82

Chains G and O: 3 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2-10	9	29
β-strand	13-24	12	29
β-strand	31-37	7	29
β-strand	42	1	30
β-strand	43-48	6	29
α-helix	49-58	10
α-helix	63-73	11
β-strand	84-88	5	31
β-strand	94-100	7	31
β-strand	105-112	8	31
β-strand	116	1	30
α-helix	119-200	82

Chain H: 15 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	2-10	9
α-helix	11-13	3
β-strand	14-18	5	32
β-strand	21-29	9	32
β-strand	33-39	7	32
β-strand	44-50	7	32
α-helix	51-61	11
α-helix	69-83	15
β-strand	94-100	7	33
β-strand	103-112	10	33
β-strand	115-123	9	33
β-strand	124-125	2	32
α-helix	126-127	2
α-helix	128-131	4
α-helix	132-136	5
α-helix	137-165	29
α-helix	166-170	5
α-helix	180-184	5
α-helix	186-192	7
α-helix	193-197	5
α-helix	198-201	4
α-helix	208-213	6
α-helix	215-223	9

Chain I: 13 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	2-10	9
α-helix	12-13	2
β-strand	14-17	4	34
β-strand	22-30	9	34
β-strand	33-39	7	34
β-strand	44-50	7	34
α-helix	51-61	11
α-helix	69-78	10
β-strand	94-100	7	35
β-strand	103-112	10	35
β-strand	115-123	9	35
β-strand	124-125	2	34
α-helix	126-127	2
α-helix	128-131	4
α-helix	132-136	5
α-helix	137-169	33
α-helix	182-184	3
α-helix	186-196	11
α-helix	198-202	5
α-helix	208-213	6
α-helix	215-223	9

Chain L: 241 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	8-18	11
α-helix	24-44	21
α-helix	50-58	9
α-helix	65-71	7
α-helix	79-95	17
α-helix	101-103	3
α-helix	104-117	14
α-helix	121-137	17
α-helix	142-147	6
α-helix	149-159	11
α-helix	168-184	17
α-helix	186-189	4
α-helix	193-208	16
α-helix	214-215	2
α-helix	217-231	15
α-helix	241-245	5
α-helix	246-256	11
α-helix	266-300	35
α-helix	306-327	22
α-helix	334-337	4
α-helix	341-351	11
α-helix	356-368	13
α-helix	370-376	7
α-helix	379-396	18
α-helix	409-421	13
α-helix	432-445	14
α-helix	446-448	3
α-helix	451-470	20
α-helix	473-491	19
α-helix	524-527	4
α-helix	528-536	9
α-helix	539-542	4
α-helix	558-578	21
α-helix	617-633	17
α-helix	635-637	3
α-helix	640-645	6
α-helix	646-659	14
α-helix	665-679	15
α-helix	683-685	3
α-helix	700-720	21
α-helix	723-733	11
α-helix	738-741	4
α-helix	749-759	11
α-helix	763-779	17
α-helix	782-785	4
α-helix	786-788	3
α-helix	789-792	4
α-helix	798-800	3
α-helix	817-824	8
α-helix	828-837	10
α-helix	848-861	14
α-helix	864-867	4
α-helix	868-870	3
α-helix	878-882	5
β-strand	884	1	49
β-strand	893-894	2	50
β-strand	905-906	2	50
α-helix	907-909	3
α-helix	911-920	10
α-helix	924-946	23
α-helix	956	1
α-helix	959-972	14
α-helix	978-994	17
α-helix	1004-1017	14
α-helix	1023-1043	21
α-helix	1046-1049	4
α-helix	1056-1067	12
α-helix	1072-1083	12
α-helix	1086-1091	6
α-helix	1093-1096	4
α-helix	1097-1110	14
α-helix	1124-1139	16
α-helix	1165-1174	10
α-helix	1181-1194	14
α-helix	1195-1197	3
α-helix	1204-1224	21
α-helix	1237-1242	6
α-helix	1253-1267	15
α-helix	1278-1281	4
α-helix	1289-1292	4
α-helix	1293-1301	9
α-helix	1324-1348	25
α-helix	1355-1361	7
α-helix	1366-1377	12
α-helix	1379-1381	3
α-helix	1384-1386	3
α-helix	1389-1408	20
α-helix	1412-1418	7
α-helix	1420-1423	4
α-helix	1426-1433	8
α-helix	1441-1461	21
α-helix	1464-1467	4
α-helix	1469-1470	2
α-helix	1477-1483	7
α-helix	1484-1488	5
α-helix	1489-1491	3
α-helix	1505-1519	15
α-helix	1525-1532	8
β-strand	1537-1538	2	51
β-strand	1553-1554	2	51
α-helix	1555-1562	8
α-helix	1564-1573	10
α-helix	1575-1584	10
α-helix	1590-1606	17
α-helix	1615-1624	10
α-helix	1626-1631	6
α-helix	1639-1656	18
α-helix	1668-1680	13
α-helix	1686-1692	7
α-helix	1707-1721	15
α-helix	1734-1753	20
α-helix	1756-1766	11
β-strand	1767	1	52
β-strand	1769	1	52
α-helix	1776-1786	11
α-helix	1791-1806	16
α-helix	1813-1818	6
α-helix	1819-1825	7
α-helix	1826-1829	4
α-helix	1832	1
α-helix	1836-1852	17
α-helix	1863-1881	19
α-helix	1886-1889	4
β-strand	1893	1	53
β-strand	1907	1	53
α-helix	1914-1923	10
α-helix	1934-1954	21
α-helix	1959-1962	4
α-helix	1975-1978	4
α-helix	2094-2105	12
α-helix	2121-2127	7
α-helix	2128-2132	5
α-helix	2140-2152	13
α-helix	2154-2157	4
α-helix	2165-2173	9
α-helix	2184-2200	17
α-helix	2206-2222	17
α-helix	2230-2244	15
α-helix	2253-2260	8
α-helix	2270-2284	15
α-helix	2296-2305	10
α-helix	2306-2308	3
α-helix	2313-2332	20
α-helix	2337-2353	17
α-helix	2357-2368	12
α-helix	2374-2384	11
α-helix	2392-2404	13
α-helix	2411-2417	7
α-helix	2420-2424	5
α-helix	2429-2441	13
α-helix	2448-2458	11
α-helix	2459-2462	4
α-helix	2467-2484	18
α-helix	2493-2508	16
α-helix	2509-2511	3
α-helix	2515-2526	12
α-helix	2535-2542	8
α-helix	2543-2545	3
α-helix	2548-2550	3
α-helix	2551-2566	16
β-strand	2575	1	54
β-strand	2586-2588	3	55
α-helix	2724-2728	5
α-helix	2736-2767	32
β-strand	2776-2778	3	55
β-strand	2786	1	54
α-helix	2788-2800	13
α-helix	2802-2819	18
α-helix	2820-2822	3
α-helix	2826-2846	21
α-helix	2852-2863	12
α-helix	2873-2882	10
α-helix	2886-2900	15
α-helix	2920-2932	13
α-helix	2936-2943	8
α-helix	2951-2961	11
α-helix	2965-2976	12
α-helix	2985-2987	3
α-helix	2988-3003	16
α-helix	3008-3017	10
α-helix	3027-3031	5
α-helix	3034-3035	2
α-helix	3036-3040	5
α-helix	3041-3053	13
α-helix	3060-3068	9
α-helix	3072-3081	10
α-helix	3083-3092	10
α-helix	3096-3115	20
α-helix	3122-3129	8
α-helix	3132-3144	13
α-helix	3149-3152	4
α-helix	3155-3165	11
α-helix	3176-3196	21
α-helix	3228-3248	21
α-helix	3252-3262	11
α-helix	3263-3265	3
α-helix	3270-3290	21
α-helix	3296-3297	2
α-helix	3298-3305	8
α-helix	3306-3307	2
α-helix	3310-3312	3
α-helix	3315-3318	4
α-helix	3321-3343	23
α-helix	3345-3347	3
α-helix	3355-3363	9
α-helix	3372-3392	21
α-helix	3409-3427	19
α-helix	3433-3439	7
α-helix	3441-3445	5
α-helix	3446-3451	6
α-helix	3452-3454	3
α-helix	3459-3463	5
α-helix	3465-3474	10
α-helix	3479-3482	4
α-helix	3483-3487	5
α-helix	3493-3496	4
α-helix	3499-3505	7
α-helix	3509-3512	4
α-helix	3515-3524	10
α-helix	3526-3537	12
α-helix	3546-3561	16
α-helix	3564-3566	3
α-helix	3567-3577	11
α-helix	3584-3596	13
α-helix	3600-3602	3
α-helix	3603-3613	11
α-helix	3614-3618	5
α-helix	3627-3635	9
α-helix	3638-3642	5
α-helix	3646-3652	7
α-helix	3660-3671	12
α-helix	3676-3678	3
α-helix	3681-3683	3
α-helix	3685-3688	4
α-helix	3697-3699	3
β-strand	3700	1	56
β-strand	3718	1	56
β-strand	3719-3722	4	57
β-strand	3727-3728	2	58
β-strand	3736-3737	2	58
β-strand	3739-3742	4	57
β-strand	3747-3749	3	57
β-strand	3753-3754	2	59
α-helix	3759-3777	19
α-helix	3779-3783	5
α-helix	3788-3790	3
β-strand	3793-3797	5	59
β-strand	3800-3803	4	59
β-strand	3810-3811	2	60
α-helix	3812-3819	8
α-helix	3822-3829	8
α-helix	3839-3845	7
α-helix	3855-3861	7
α-helix	3866-3877	12
α-helix	3882-3890	9
β-strand	3891	1	49
α-helix	3894-3917	24
β-strand	3928-3930	3	60
β-strand	3937-3939	3	60
α-helix	3965-3970	6
α-helix	3979-3991	13
α-helix	3995-3997	3
α-helix	3999-4001	3
α-helix	4040-4052	13
β-strand	4054	1	61
α-helix	4056-4067	12
α-helix	4074-4082	9
β-strand	4096	1	61
α-helix	4100-4112	13
α-helix	4114-4118	5

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
X-ray repair cross-complementing protein 6	A, J	protein	609	Homo sapiens	P12956 (AlphaFold model)
X-ray repair cross-complementing protein 5	B, K	protein	732	Homo sapiens	P13010 (AlphaFold model)
DNA-dependent protein kinase catalytic subunit	C, L	protein	4128	Homo sapiens	P78527
Unknown peptide	Q, R	protein	20	Homo sapiens
DNA (31-mer)	D, M	DNA	31	Homo sapiens
DNA (30-mer)	E, N	DNA	30	Homo sapiens
DNA repair protein XRCC4	F, G, O, P	protein	336	Homo sapiens	Q13426 (AlphaFold model)
Non-homologous end-joining factor 1	H, I	protein	299	Homo sapiens	Q9H9Q4
DNA ligase 4	X, Y	protein	911	Homo sapiens	P49917

Sequence of entity 1 (A, J), FASTA

>7LT3_1 X-ray repair cross-complementing protein 6 (chains A, J)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD

Sequence of entity 2 (B, K), FASTA

>7LT3_2 X-ray repair cross-complementing protein 5 (chains B, K)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI

Sequence of entity 3 (C, L), FASTA

>7LT3_3 DNA-dependent protein kinase catalytic subunit (chains C, L)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM

Sequence of entity 4 (Q, R), FASTA

>7LT3_4 Unknown peptide (chains Q, R)
XXXXXXXXXXXXXXXXXXXX

Sequence of entity 5 (D, M), FASTA

>7LT3_5 DNA (31-MER) (chains D, M)
TCTAAGAACTCTGATGTCAGTAGATTACACT

Sequence of entity 6 (E, N), FASTA

>7LT3_6 DNA (30-MER) (chains E, N)
GTGTAATCTACTGACATCAGAGTTCTTAGA

Sequence of entity 7 (F, G, O, P), FASTA

>7LT3_7 DNA repair protein XRCC4 (chains F, G, O, P)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI

Sequence of entity 8 (H, I), FASTA

>7LT3_8 Non-homologous end-joining factor 1 (chains H, I)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS

Sequence of entity 9 (X, Y), FASTA

>7LT3_9 DNA ligase 4 (chains X, Y)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	2

Primary citation

Structural basis of long-range to short-range synaptic transition in NHEJ. Chen, S., Lee, L., Naila, T. et al. Nature (2021) 593:294-298. DOI 10.1038/s41586-021-03458-7 · PubMed

Other PDB entries of the same protein (UniProt P12956 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8AG4 2.46 Å, Vaccinia C16 protein bound to Ku70/Ku80
1JEY 2.5 Å, Crystal Structure of the Ku heterodimer bound to DNA
3RZX 2.61 Å, Mouse importin alpha-Ku70 NLS peptide complex
7ZYG 2.68 Å, CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
1JEQ 2.7 Å, Crystal Structure of the Ku Heterodimer
7ZVT 2.74 Å, CryoEM structure of Ku heterodimer bound to DNA
6ERH 2.8 Å, Complex of XLF and heterodimer Ku bound to DNA
7ZWA 2.8 Å, CryoEM structure of Ku heterodimer bound to DNA and PAXX
9CQ3 2.8 Å, The gap-filling complex with Pol mu engaged in the NHEJ pathway
9GYF 2.8 Å, Ku70/80 with PAXX peptide mutation K193R
9N81 2.8 Å, A gap-filling complex with Pol mu engaged in the NHEJ Pathway
6ERG 2.9 Å, Complex of XLF and heterodimer Ku bound to DNA

Browse structure collections

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