Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (P3221 crystal form). Determined by X-ray diffraction at 1.65 Å resolution. Released 1 Jun 2022.
Explore 7OIT in 3D Show helices and sheets RCSB PDB PDBe
7OIT contains 6 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 172-185 | 14 | 1 |
| β-strand | 191-205 | 15 | 1 |
| β-strand | 211-216 | 6 | 2 |
| β-strand | 218 | 1 | 3 |
| β-strand | 241 | 1 | 3 |
| β-strand | 245-248 | 4 | 1 |
| α-helix | 254-260 | 7 | |
| β-strand | 263-265 | 3 | 2 |
| α-helix | 267-268 | 2 | |
| β-strand | 270-279 | 10 | 1 |
| β-strand | 287-296 | 10 | 4 |
| β-strand | 300-309 | 10 | 4 |
| β-strand | 316-325 | 10 | 1 |
| β-strand | 330-337 | 8 | 4 |
| β-strand | 341-345 | 5 | 1 |
| α-helix | 346-348 | 3 | |
| β-strand | 350-359 | 10 | 1 |
| β-strand | 363-372 | 10 | 4 |
| α-helix | 383-385 | 3 | |
| β-strand | 386-392 | 7 | 1 |
| β-strand | 401-408 | 8 | 2 |
| β-strand | 413-414 | 2 | 2 |
| α-helix | 415-417 | 3 | |
| β-strand | 419-433 | 15 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 108-110 | 3 | |
| β-strand | 112-113 | 2 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| AP-2 complex subunit mu | AAA | protein | 285 | Rattus norvegicus | A0A140TAH5 (AlphaFold model) |
| F-BAR domain only protein 2 | BBB | protein | 11 | Homo sapiens | Q0JRZ9 (AlphaFold model) |
>7OIT_1 AP-2 complex subunit mu (chains AAA) MHHHHHHQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMP ECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDG EFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNT SGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNF EVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
>7OIT_2 F-BAR domain only protein 2 (chains BBB) SDLLAWDPLFG
FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Zaccai, N.R., Kadlecova, Z., Dickson, V.K. et al. Sci Adv (2022) 8:eabn2018-eabn2018. DOI 10.1126/sciadv.abn2018 · PubMed
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