7OW4: HLA-A*11:01

Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK). Determined by X-ray diffraction at 1.81 Å resolution. Released 20 Jul 2022.

Method: X-ray diffraction
Resolution: 1.81 Å
Organism: Homo sapiens
Chains: 12
Atoms: 13,589
Mol. weight: 179.41 kDa
Released: 20 Jul 2022

Explore 7OW4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OW4 contains 49 α-helices and 120 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chains B and K: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 9 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-14	12	8
β-strand	18-28	11	8
β-strand	31-37	7	8
β-strand	46-47	2	8
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	8
β-strand	109-118	10	8
β-strand	121-126	6	8
β-strand	133-135	3	8
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	9
α-helix	184-185	2
β-strand	186-193	8	10
β-strand	198-208	11	10
β-strand	209	1	9
β-strand	214-219	6	11
β-strand	222-224	3	11
β-strand	228-230	3	10
α-helix	231-233	3
β-strand	234-235	2	10
β-strand	241-250	10	10
α-helix	254-256	3
β-strand	257-262	6	11
β-strand	270-272	3	11

Chains E and H: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	12
α-helix	4-5	2
β-strand	6-11	6	13
β-strand	21-30	10	13
β-strand	31	1	12
β-strand	36-41	6	14
β-strand	44-45	2	14
β-strand	50-51	2	13
α-helix	52-54	3
β-strand	55-56	2	13
β-strand	62-70	9	13
β-strand	78-83	6	14
β-strand	91-94	4	14

Chains G and J: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	15
α-helix	20	1
β-strand	21-28	8	15
β-strand	31-37	7	15
β-strand	46-47	2	15
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	15
β-strand	109-118	10	15
β-strand	121-126	6	15
β-strand	133-135	3	15
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	16
α-helix	184-185	2
β-strand	186-193	8	17
β-strand	198-208	11	17
β-strand	209	1	16
β-strand	214-219	6	18
β-strand	222-224	3	18
β-strand	228-230	3	17
α-helix	231-233	3
β-strand	234-235	2	17
β-strand	241-250	10	17
α-helix	254-256	3
β-strand	257-262	6	18
β-strand	270-272	3	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A, D, G, J	protein	276	Homo sapiens	A0A583ZB34 (AlphaFold model)
Beta-2-microglobulin	B, E, H, K	protein	100	Homo sapiens	P61769 (AlphaFold model)
KRAS G12D peptide (VVVGADGVGK)	C, F, I, L	protein	10	Homo sapiens	P01111 (AlphaFold model)

Sequence of entity 1 (A, D, G, J), FASTA

>7OW4_1 MHC class I antigen (chains A, D, G, J)
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDG
KDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQ
RTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP

Sequence of entity 2 (B, E, H, K), FASTA

>7OW4_2 Beta-2-microglobulin (chains B, E, H, K)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, F, I, L), FASTA

>7OW4_3 KRAS G12D peptide (VVVGADGVGK) (chains C, F, I, L)
VVVGADGVGK

Primary citation

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen. Poole, A., Karuppiah, V., Hartt, A. et al. Nat Commun (2022) 13:5333. DOI 10.1038/s41467-022-32811-1

Other PDB entries of the same protein (UniProt A0A583ZB34 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8RYN 1.97 Å, Structure of S2 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
8WTE 2.17 Å, Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide…
8WUL 2.36 Å, Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to…
7OW3 2.46 Å, Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVVGAGGVGK)
8RYQ 2.49 Å, Structure of S8-9F3 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
7OW5 2.58 Å, Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVVGAGGVGK)
7OW6 2.64 Å, Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide…
7PB2 3.41 Å, Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide…

Browse structure collections

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