Crystal structure of stabilized H3N2 A/Hong Kong/1/1968 Hemagglutinin at 2.2 Angstrom. Determined by X-ray diffraction at 2.19 Å resolution. Released 2 Feb 2022.
Explore 7QA4 in 3D Show helices and sheets RCSB PDB PDBe
7QA4 contains 13 α-helices and 45 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 11-17 | 7 | 1 |
| β-strand | 18 | 1 | 2 |
| β-strand | 24-26 | 3 | 3 |
| β-strand | 34-36 | 3 | 3 |
| β-strand | 39-41 | 3 | 4 |
| β-strand | 43-44 | 2 | 5 |
| β-strand | 51-54 | 4 | 6 |
| β-strand | 58-60 | 3 | 7 |
| α-helix | 66-71 | 6 | |
| α-helix | 74-79 | 6 | |
| β-strand | 83 | 1 | 8 |
| β-strand | 86-89 | 4 | 7 |
| β-strand | 100-101 | 2 | 9 |
| α-helix | 105-115 | 11 | |
| β-strand | 117 | 1 | 8 |
| β-strand | 120-122 | 3 | 9 |
| β-strand | 130-134 | 5 | 9 |
| β-strand | 136-140 | 5 | 10 |
| β-strand | 145-146 | 2 | 10 |
| β-strand | 151-156 | 6 | 9 |
| β-strand | 157 | 1 | 11 |
| β-strand | 160 | 1 | 11 |
| β-strand | 164-169 | 6 | 12 |
| α-helix | 175 | 1 | |
| β-strand | 176-184 | 9 | 9 |
| α-helix | 188-194 | 7 | |
| β-strand | 201-205 | 5 | 12 |
| β-strand | 210-213 | 4 | 12 |
| α-helix | 219-221 | 3 | |
| β-strand | 223 | 1 | 13 |
| β-strand | 226 | 1 | 13 |
| β-strand | 229-237 | 9 | 9 |
| β-strand | 242-249 | 8 | 12 |
| β-strand | 251-254 | 4 | 9 |
| β-strand | 256-259 | 4 | 9 |
| α-helix | 260 | 1 | |
| β-strand | 266-269 | 4 | 7 |
| α-helix | 272-273 | 2 | |
| β-strand | 274-278 | 5 | 6 |
| β-strand | 281-283 | 3 | 14 |
| β-strand | 286-288 | 3 | 14 |
| β-strand | 294-295 | 2 | 5 |
| β-strand | 302 | 1 | 14 |
| β-strand | 303-304 | 2 | 15 |
| α-helix | 306 | 1 | |
| β-strand | 307-308 | 2 | 5 |
| β-strand | 315-317 | 3 | 4 |
| β-strand | 321 | 1 | 3 |
| β-strand | 343 | 1 | 2 |
| β-strand | 351-357 | 7 | 1 |
| β-strand | 360-366 | 7 | 1 |
| α-helix | 367-384 | 18 | |
| β-strand | 390-391 | 2 | 15 |
| α-helix | 405-455 | 51 | |
| β-strand | 459-461 | 3 | 1 |
| β-strand | 466-469 | 4 | 1 |
| α-helix | 475-482 | 8 | |
| α-helix | 488-500 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Hemagglutinin | A | protein | 512 | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | Q91MA7 |
>7QA4_1 Hemagglutinin (chains A) QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILD GIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEF ITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIW GVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPG DVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKI TYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRWQNSEG TGQAADLKSTQAAIDQINGILNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDL WSYNAELLVALINQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIES IRNGTYDHDVYRDEALNNRFQIKGVGGSEPEA
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
Water and common crystallization additives (NO3) are not listed.
Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions. Milder, F.J., Jongeneelen, M., Ritschel, T. et al. Proc Natl Acad Sci U S A (2022) 119. DOI 10.1073/pnas.2115379119 · PubMed
Other PDB entries of the same protein (UniProt Q91MA7), best resolution first:
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