7QJ6: Actin, cytoplasmic 1
Structure of recombinant human gamma-Tubulin Ring Complex 10-spoked assembly intermediate (spokes 3-12, substoichiometric spokes 13-14). Determined by electron microscopy at 7.8 Å resolution. Released 26 Jan 2022.
- Method
- Electron microscopy
- Resolution
- 7.8 Å
- Organism
- Homo sapiens
- Chains
- 31
- Atoms
- 91,575
- Mol. weight
- 2317.51 kDa
- Released
- 26 Jan 2022
Explore 7QJ6 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7QJ6 contains 527 α-helices and 206 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains a and j: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-20 | 12 | |
| α-helix | 30-39 | 10 | |
| α-helix | 51-64 | 14 | |
| α-helix | 69-84 | 16 | |
| α-helix | 90-99 | 10 | |
Chains b, k and m: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-34 | 22 | |
| α-helix | 41-53 | 13 | |
| α-helix | 57-67 | 11 | |
Chain c: 8 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-14 | 11 | |
| α-helix | 17-18 | 2 | |
| α-helix | 32-50 | 19 | |
| α-helix | 66-79 | 14 | |
| α-helix | 83-96 | 14 | |
| α-helix | 110-114 | 5 | |
| α-helix | 158-173 | 16 | |
| α-helix | 176-182 | 7 | |
Chain C: 34 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 152-167 | 16 | |
| α-helix | 179-183 | 5 | |
| α-helix | 185-187 | 3 | |
| α-helix | 210-225 | 16 | |
| β-strand | 234-235 | 2 | 4 |
| α-helix | 236-237 | 2 | |
| β-strand | 246-247 | 2 | 4 |
| α-helix | 248-249 | 2 | |
| α-helix | 254-280 | 27 | |
| α-helix | 289-292 | 4 | |
| α-helix | 297-315 | 19 | |
| α-helix | 321-327 | 7 | |
| α-helix | 330-332 | 3 | |
| α-helix | 338-345 | 8 | |
| α-helix | 353-358 | 6 | |
| α-helix | 372-381 | 10 | |
| α-helix | 384-394 | 11 | |
| β-strand | 409-411 | 3 | 5 |
| β-strand | 432-434 | 3 | 5 |
| α-helix | 441-443 | 3 | |
| α-helix | 447-461 | 15 | |
| α-helix | 487-505 | 19 | |
| α-helix | 510-520 | 11 | |
| α-helix | 526-534 | 9 | |
| α-helix | 536-540 | 5 | |
| α-helix | 542 | 1 | |
| α-helix | 548-561 | 14 | |
| α-helix | 570-572 | 3 | |
| β-strand | 573-577 | 5 | 6 |
| α-helix | 613-615 | 3 | |
| β-strand | 616-620 | 5 | 6 |
| α-helix | 632-662 | 31 | |
| α-helix | 678-696 | 19 | |
| α-helix | 697-702 | 6 | |
| α-helix | 703-712 | 10 | |
| α-helix | 719-736 | 18 | |
| α-helix | 747-759 | 13 | |
| α-helix | 766-768 | 3 | |
| α-helix | 818-842 | 25 | |
| α-helix | 854-859 | 6 | |
Chain d: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-31 | 12 | |
| α-helix | 41-53 | 13 | |
| α-helix | 57-74 | 18 | |
Chain D: 29 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 247-258 | 12 | |
| β-strand | 266-268 | 3 | 7 |
| β-strand | 275-277 | 3 | 7 |
| α-helix | 287-294 | 8 | |
| α-helix | 296-310 | 15 | |
| α-helix | 318-345 | 28 | |
| α-helix | 372-387 | 16 | |
| α-helix | 393-395 | 3 | |
| α-helix | 409-415 | 7 | |
| α-helix | 419-429 | 11 | |
| β-strand | 448-450 | 3 | 8 |
| β-strand | 464-466 | 3 | 8 |
| α-helix | 468-470 | 3 | |
| α-helix | 477-482 | 6 | |
| α-helix | 484-492 | 9 | |
| α-helix | 493-497 | 5 | |
| α-helix | 534-551 | 18 | |
| α-helix | 556-565 | 10 | |
| α-helix | 571-580 | 10 | |
| α-helix | 583-586 | 4 | |
| α-helix | 594-604 | 11 | |
| α-helix | 615-619 | 5 | |
| β-strand | 621-625 | 5 | 9 |
| α-helix | 634-636 | 3 | |
| β-strand | 638-642 | 5 | 9 |
| α-helix | 647-649 | 3 | |
| α-helix | 654-688 | 35 | |
| α-helix | 690-692 | 3 | |
| α-helix | 698-721 | 24 | |
| α-helix | 722-728 | 7 | |
| α-helix | 729-740 | 12 | |
| α-helix | 744-761 | 18 | |
| α-helix | 769-810 | 42 | |
| α-helix | 827-864 | 38 | |
| α-helix | 874-878 | 5 | |
Chain e: 25 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-12 | 5 | 1 |
| β-strand | 16-21 | 6 | 1 |
| β-strand | 29-32 | 4 | 1 |
| α-helix | 56-60 | 5 | |
| α-helix | 62-64 | 3 | |
| β-strand | 71 | 1 | 2 |
| β-strand | 76 | 1 | 2 |
| α-helix | 79-88 | 10 | |
| α-helix | 89-94 | 6 | |
| α-helix | 98-100 | 3 | |
| β-strand | 103-107 | 5 | 1 |
| α-helix | 113-126 | 14 | |
| β-strand | 131-136 | 6 | 1 |
| α-helix | 137-144 | 8 | |
| β-strand | 149-155 | 7 | 3 |
| β-strand | 160-166 | 7 | 3 |
| β-strand | 169-170 | 2 | 3 |
| α-helix | 175 | 1 | |
| β-strand | 176-178 | 3 | 3 |
| α-helix | 182-196 | 15 | |
| α-helix | 203-211 | 9 | |
| α-helix | 212-216 | 5 | |
| α-helix | 224-232 | 9 | |
| α-helix | 252-256 | 5 | |
| α-helix | 257-261 | 5 | |
| α-helix | 264-266 | 3 | |
| α-helix | 272-273 | 2 | |
| α-helix | 274-283 | 10 | |
| α-helix | 287-294 | 8 | |
| β-strand | 297-299 | 3 | 3 |
| α-helix | 302-305 | 4 | |
| α-helix | 309-320 | 12 | |
| α-helix | 326-327 | 2 | |
| β-strand | 329-330 | 2 | 3 |
| α-helix | 338-346 | 9 | |
| α-helix | 351-354 | 4 | |
| β-strand | 357-358 | 2 | 1 |
| α-helix | 359-364 | 6 | |
| α-helix | 369-373 | 5 | |
Chain E: 28 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 153-168 | 16 | |
| α-helix | 172-175 | 4 | |
| α-helix | 179-183 | 5 | |
| α-helix | 210-225 | 16 | |
| β-strand | 233-236 | 4 | 10 |
| α-helix | 237 | 1 | |
| β-strand | 245-248 | 4 | 10 |
| α-helix | 254-271 | 18 | |
| α-helix | 274-279 | 6 | |
| α-helix | 288-295 | 8 | |
| α-helix | 298-316 | 19 | |
| α-helix | 321-327 | 7 | |
| α-helix | 329-347 | 19 | |
| α-helix | 355-365 | 11 | |
| α-helix | 374-394 | 21 | |
| β-strand | 409-411 | 3 | 11 |
| β-strand | 432-434 | 3 | 11 |
| α-helix | 447-463 | 17 | |
| α-helix | 483-505 | 23 | |
| α-helix | 509-520 | 12 | |
| α-helix | 525-539 | 15 | |
| α-helix | 542 | 1 | |
| α-helix | 548-561 | 14 | |
| α-helix | 625-627 | 3 | |
| α-helix | 632-661 | 30 | |
| α-helix | 678-697 | 20 | |
| α-helix | 698-702 | 5 | |
| α-helix | 703-712 | 10 | |
| α-helix | 722-736 | 15 | |
| α-helix | 746-770 | 25 | |
| α-helix | 815-841 | 27 | |
| α-helix | 854-859 | 6 | |
11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| actin, cytoplasmic 1 | e | protein | 375 | Homo sapiens | P60709 (AlphaFold model) |
| Mitotic-spindle organizing protein 1 | b, d, i, k, m | protein | 82 | Homo sapiens | Q08AG7 (AlphaFold model) |
| Gamma-tubulin complex component 3 | D, F, H, a, h, j | protein | 907 | Homo sapiens | Q96CW5 (AlphaFold model) |
| Gamma-tubulin complex component 2 | C, E, G | protein | 902 | Homo sapiens | Q9BSJ2 (AlphaFold model) |
| Gamma-tubulin complex component 4 | I, K | protein | 667 | Homo sapiens | Q9UGJ1 |
| Gamma-tubulin complex component 5 | J, l | protein | 1024 | Homo sapiens | Q96RT8 |
| Gamma-tubulin complex component 6 | L, c | protein | 1819 | Homo sapiens | Q96RT7 |
| Tubulin gamma-1 chain | Q, R, S, T, U, V, W, X, Y, Z | protein | 451 | Homo sapiens | P23258 |
Sequence of entity 1 (e), FASTA
>7QJ6_1 actin, cytoplasmic 1 (chains e)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 2 (b, d, i, k, m), FASTA
>7QJ6_2 Mitotic-spindle organizing protein 1 (chains b, d, i, k, m)
MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEAL
SSVIKELRKATEALKAAENMTS
Sequence of entity 3 (D, F, H, a, h, j), FASTA
>7QJ6_3 Gamma-tubulin complex component 3 (chains D, F, H, a, h, j)
MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT
Sequence of entity 4 (C, E, G), FASTA
>7QJ6_4 Gamma-tubulin complex component 2 (chains C, E, G)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSI
NVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAW
VYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAG
RQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLV
KEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLH
DRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQ
EDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLK
ERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELR
KPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAM
AHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWI
SNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNID
DVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTL
EHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARL
SIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVT
AQ
Sequence of entity 5 (I, K), FASTA
>7QJ6_5 Gamma-tubulin complex component 4 (chains I, K)
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSIS
HVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Sequence of entity 6 (J, l), FASTA
>7QJ6_6 Gamma-tubulin complex component 5 (chains J, l)
MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFAWSNFRFHRFLDVNSHK
IEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDS
PSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSRE
DSGIQVDRTPLEEQDQNRKLDPCISWKDEPDDRSWLEHHVVHQYWTARPSQFPHSLHLHS
NLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLSGVKKLFIFQLIDGKVTVRNNI
IVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRT
YQAFMWALYKYFISFKEELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGV
AEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWI
VHGHLWDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQG
PSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESV
QSRLRHGEDSTPQVLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDF
HEKFAGGDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYL
QAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSIS
FENVDTAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDV
LLFGELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNY
IMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNL
ALMFADGWQAGLGTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAG
MEQS
Sequence of entity 7 (L, c), FASTA
>7QJ6_7 Gamma-tubulin complex component 6 (chains L, c)
MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD
MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS
GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ
VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD
LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV
GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL
IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD
SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK
TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE
KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR
QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW
RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG
QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL
PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA
VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ
PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH
GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA
SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE
SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV
STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR
LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL
SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE
PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN
KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS
VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC
VSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI
QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI
FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ
PHLEDFLLRINFNNYYQDA
Sequence of entity 8 (Q, R, S, T, U, V, W, X, Y, Z), FASTA
>7QJ6_8 Tubulin gamma-1 chain (chains Q, R, S, T, U, V, W, X, Y, Z)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQ
Primary citation
Modular assembly of the principal microtubule nucleator gamma-TuRC. Wurtz, M., Zupa, E., Atorino, E.S. et al. Nat Commun (2022) 13:473-473. DOI 10.1038/s41467-022-28079-0 · PubMed
Other PDB entries of the same protein (UniProt P60709 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6MBK 1.69 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First…
- 6OX0 1.75 Å, SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor
- 6MBJ 1.78 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, P21…
- 6OX3 1.78 Å, SETD3 in Complex with an Actin Peptide with His73 Replaced with Lysine
- 7W28 1.79 Å, Crystal Structure of SETD3-SAH in complex with betaA-4PyrAla73 peptide
- 6OX1 1.95 Å, SETD3 in Complex with an Actin Peptide with Target Histidine Partially Methylated
- 6ICT 1.95 Å, Structure of SETD3 bound to SAH and methylated actin
- 6OX2 2.09 Å, SETD3in Complex with an Actin Peptide with the Target Histidine Fully Methylated
- 6OX5 2.1 Å, A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine
- 6ICV 2.15 Å, Structure of SETD3 bound to SAH and unmodified actin
- 9QEW 2.18 Å, Cryo-EM structure of the undecorated actin filament in the ADP-Pi state.
- 6MBL 2.2 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second…
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