Cryo-EM structure of Xenopus Patched-1 in nanodisc. Determined by electron microscopy at 3.0 Å resolution. Released 2 Mar 2022.
Explore 7RHR in 3D Show helices and sheets RCSB PDB PDBe
7RHR contains 52 α-helices and 26 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 70-86 | 17 | |
| α-helix | 90-105 | 16 | |
| β-strand | 111 | 1 | 1 |
| α-helix | 115-117 | 3 | |
| α-helix | 125-136 | 12 | |
| β-strand | 144-152 | 9 | 2 |
| α-helix | 162-174 | 13 | |
| β-strand | 180-182 | 3 | 3 |
| β-strand | 185-187 | 3 | 3 |
| α-helix | 189-192 | 4 | |
| β-strand | 193 | 1 | 2 |
| α-helix | 205-213 | 9 | |
| α-helix | 215-216 | 2 | |
| β-strand | 218-219 | 2 | 2 |
| α-helix | 221-224 | 4 | |
| α-helix | 226-228 | 3 | |
| β-strand | 236-237 | 2 | 4 |
| β-strand | 243-244 | 2 | 4 |
| α-helix | 253-260 | 8 | |
| α-helix | 266-275 | 10 | |
| α-helix | 285-286 | 2 | |
| α-helix | 306-307 | 2 | |
| α-helix | 309-313 | 5 | |
| β-strand | 317-318 | 2 | 5 |
| β-strand | 326-327 | 2 | 5 |
| α-helix | 329-332 | 4 | |
| β-strand | 333-334 | 2 | 2 |
| β-strand | 337-338 | 2 | 6 |
| β-strand | 344-346 | 3 | 6 |
| β-strand | 349-356 | 8 | 2 |
| α-helix | 359-365 | 7 | |
| α-helix | 379-399 | 21 | |
| β-strand | 407-412 | 6 | 2 |
| α-helix | 414-422 | 9 | |
| α-helix | 429-447 | 19 | |
| α-helix | 457-480 | 24 | |
| β-strand | 485 | 1 | 1 |
| α-helix | 493-517 | 25 | |
| α-helix | 526-552 | 27 | |
| α-helix | 558-580 | 23 | |
| α-helix | 582-594 | 13 | |
| α-helix | 725-734 | 10 | |
| α-helix | 737-757 | 21 | |
| β-strand | 763 | 1 | 7 |
| α-helix | 767-769 | 3 | |
| α-helix | 776-787 | 12 | |
| β-strand | 790-797 | 8 | 8 |
| α-helix | 806-814 | 9 | |
| β-strand | 822 | 1 | 8 |
| α-helix | 830-832 | 3 | |
| α-helix | 834-854 | 21 | |
| α-helix | 868-878 | 11 | |
| β-strand | 879 | 1 | 9 |
| β-strand | 886 | 1 | 9 |
| α-helix | 888-890 | 3 | |
| β-strand | 898 | 1 | 10 |
| β-strand | 904 | 1 | 10 |
| α-helix | 909-919 | 11 | |
| α-helix | 921-926 | 6 | |
| α-helix | 934-937 | 4 | |
| α-helix | 954-958 | 5 | |
| β-strand | 961-968 | 8 | 8 |
| α-helix | 973-991 | 19 | |
| β-strand | 997-1000 | 4 | 8 |
| α-helix | 1002-1005 | 4 | |
| α-helix | 1009-1011 | 3 | |
| α-helix | 1013-1036 | 24 | |
| α-helix | 1039-1063 | 25 | |
| α-helix | 1065-1066 | 2 | |
| β-strand | 1067 | 1 | 7 |
| α-helix | 1069-1095 | 27 | |
| α-helix | 1100-1111 | 12 | |
| α-helix | 1113-1125 | 13 | |
| α-helix | 1126-1129 | 4 | |
| α-helix | 1138-1142 | 5 | |
| α-helix | 1143-1154 | 12 | |
| α-helix | 1155-1159 | 5 | |
| α-helix | 1160-1166 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Patched-1 | A | protein | 1205 | Xenopus calcaratus | Q98SW6 |
>7RHR_1 Patched-1 (chains A) MASAACAAELGASGEAAAQPRVVRRRGRSRRVAPPDHDYLQRPSYCDANFALQQISEGKA IGRKAPLWLRAFFQRQLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAANLETNVEELWV EVGGRVSRELDYTRQKIGEEAMFNPQLMIQTPLEDGANVLTTEALLQHLHSALEATKVQV YMYNKPWKLEELCFKSGELITEAVYVSQIIDSMYPCLIITPLDCFWEGAKLQSGMAYLPG KDILQWTNFDPLELLEELKKGKLHIDIWEEMINKAEVGHGYMDRPCLNPSDKNCPYTAPN KNSTKPVDVSLILSGGCYGLSKKYMHWQEELIIGGTVKNASGQIVSALALQTMFQLMTPK QMYEHFKGHEVVSHMNWNEDKAAAILEAWQRTYVQVVHQSVPQNSSQKVLPFTTTTLDDI LKSFSDVSVIRVASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSL IGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVAL TSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREVRRLDI FCCFSSPCVSRVIQIEPQAYTDNNDNTRYSLPPTYSSHSFAHETQITMQSTVQLRTEYDP RTQLYYTTAQPRSEISVQPAASTPQDVSGQTPESTSSTRDLISQFSVHGGSMQCTPDSKW TLSSFAEKHYAPFLLKPKTKVAVILGFLALLSVSLYGTTRVRDGLDLTDIVPRETREYDF IATQFKYFSFYHMYVVTQKADYPRAQRLLYELHKSFVGVRYVLLEGNKQLPKMWLHYFRD WLQGLQDTFDHEWEAGKITRNDYRNASDDAVLAYKLLIQTGNSDKPINLNQLTKQRLVDA DGIIQPNAFYIYLTAWVSNDPVAYAASQANIRPHPPEWLHDKADDRPETRTIRAAEPIEY VQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGVSSYPNGYPFLFWEQYISLRHWLLLS ISVVLACTFLVCALFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVG IGVEFTVHVALAFLTAVGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY FFAVLAILTLLGVLNGLVLLPVLLSFFGPYPEVSPTNGSSSPAAAHHHHHHHHEDQVDPR LIDGK
Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Huang, P., Wierbowski, B.M., Lian, T. et al. Dev Cell (2022) 57:670-685.e8. DOI 10.1016/j.devcel.2022.02.008 · PubMed
Other PDB entries of the same protein (UniProt Q98SW6), best resolution first:
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