7S8R: HLA A*1101

Crystal Structure of HLA A*1101 in complex with SALEWIKNK, an 9-mer epitope from Influenza B. Determined by X-ray diffraction at 2.95 Å resolution. Released 23 Feb 2022.

Method: X-ray diffraction
Resolution: 2.95 Å
Organisms: Homo sapiens, Influenza B virus
Chains: 6
Atoms: 6,354
Mol. weight: 90.49 kDa
Ligands: MG
Released: 23 Feb 2022

Explore 7S8R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7S8R contains 22 α-helices and 61 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
α-helix	45	1
β-strand	46-47	2	1
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	140-149	10
α-helix	152-161	10
α-helix	164-174	11
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	213-219	7	4
β-strand	222-223	2	4
β-strand	228-230	3	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-263	7	4
β-strand	270-272	3	4

Chain B: 3 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	5
α-helix	4-5	2
β-strand	6	1	6
β-strand	9-11	3	7
β-strand	21-30	10	7
β-strand	31	1	5
β-strand	35-41	7	8
β-strand	44-45	2	8
α-helix	46	1
β-strand	50-51	2	7
α-helix	52-54	3
β-strand	55-56	2	7
β-strand	62-70	9	7
β-strand	78-84	7	8
β-strand	91-94	4	8

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	6-8	3

Chain D: 8 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	9
α-helix	20	1
β-strand	21-28	8	9
β-strand	31-37	7	9
β-strand	46-47	2	9
α-helix	53-55	3
α-helix	57-84	28
β-strand	94-103	10	9
β-strand	109-118	10	9
β-strand	121-126	6	9
β-strand	133-135	3	9
α-helix	138-149	12
α-helix	152-159	8
α-helix	160-164	5
α-helix	165-174	10
β-strand	183	1	10
β-strand	186-193	8	11
β-strand	198-208	11	11
β-strand	209	1	10
β-strand	213-219	7	12
β-strand	222-223	2	12
β-strand	228-230	3	11
β-strand	234-235	2	11
β-strand	241-250	10	11
α-helix	254-256	3
β-strand	257-263	7	12
β-strand	270-272	3	12

Chain E: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	5
α-helix	4-5	2
β-strand	6-11	6	13
β-strand	21-30	10	13
β-strand	31	1	5
β-strand	35-41	7	14
β-strand	44-45	2	14
α-helix	46	1
β-strand	50-51	2	13
β-strand	55-56	2	13
β-strand	62-70	9	13
β-strand	78-84	7	14
β-strand	91-94	4	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA class I histocompatibility antigen, A alpha chain	A, D	protein	278	Homo sapiens	U5YJK1 (AlphaFold model)
Beta-2-microglobulin	B, E	protein	100	Homo sapiens	P61769 (AlphaFold model)
Matrix protein 1 peptide SALEWIKNK	C, F	protein	9	Influenza B virus	P06816

Sequence of entity 1 (A, D), FASTA

>7S8R_1 HLA class I histocompatibility antigen, A alpha chain (chains A, D)
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDG
KDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQ
RTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSS

Sequence of entity 2 (B, E), FASTA

>7S8R_2 Beta-2-microglobulin (chains B, E)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, F), FASTA

>7S8R_3 Matrix protein 1 peptide SALEWIKNK (chains C, F)
SALEWIKNK

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	3

Water and common crystallization additives (SO4) are not listed.

Primary citation

HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people. Habel, J.R., Nguyen, A.T., Rowntree, L.C. et al. PLoS Pathog (2022) 18:e1010337-e1010337. DOI 10.1371/journal.ppat.1010337 · PubMed

Other PDB entries of the same protein (UniProt U5YJK1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7M8T 1.5 Å, Crystal Structure of HLA-A*11:01 in complex with NSASFSTFK, an 9-mer epitope from…
7S8S 1.87 Å, Crystal Structure of HLA A*1101 in complex with RVLVNGTFLK, an 10-mer epitope from…
7S8Q 2.08 Å, Crystal Structure of HLA A*1101 in complex with KTNGNAFIGK, an 10-mer epitope from…

Browse structure collections

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