7T7C: Protein unc-13 homolog A Chimera

The hexagonal organization of Munc13-1 C1-C2B-MUN-C2C domains between lipid bilayers. Determined by electron microscopy at 10.0 Å resolution. Released 9 Feb 2022.

Method
Electron microscopy
Resolution
10.0 Å
Organism
Rattus norvegicus
Chains
12
Atoms
108,408
Mol. weight
1570.75 kDa
Released
9 Feb 2022

Explore 7T7C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7T7C contains 648 α-helices and 330 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C, D, E, F and G: 54 helices, 30 β-strands

ElementResiduesLengthSheet
α-helix16-3015
α-helix36-394
β-strand41-4441
β-strand50-5122
β-strand58-5922
β-strand6013
β-strand6413
β-strand66-6941
β-strand75-7621
α-helix88-9811
α-helix102-12221
α-helix124-13310
α-helix138-15316
β-strand161-171114
α-helix173-1753
β-strand184-19075
β-strand193-19645
α-helix197-1993
β-strand207-216104
β-strand222-22985
α-helix234-2429
β-strand249-25685
α-helix257-2593
β-strand262-26984
α-helix2701
β-strand27115
β-strand282-291104
β-strand29414
α-helix297-2993
α-helix300-31314
α-helix314-3196
α-helix334-3363
α-helix341-35313
α-helix358-37114
α-helix378-39518
α-helix404-4096
α-helix415-43319
α-helix436-4394
α-helix445-46723
α-helix477-50832
α-helix512-5143
α-helix531-54616
α-helix547-5515
α-helix552-5543
α-helix564-59027
α-helix595-61218
α-helix617-6204
α-helix626-65833
β-strand66316
β-strand67116
α-helix672-69120
α-helix696-72833
α-helix735-75723
α-helix760-7623
α-helix765-79228
α-helix794-80815
α-helix814-8163
α-helix825-85026
α-helix853-87119
α-helix872-8765
α-helix880-8812
α-helix882-8865
α-helix899-91719
α-helix918-9203
α-helix925-9295
α-helix932-94514
α-helix948-95811
β-strand96717
β-strand972-981108
β-strand988-998118
β-strand1010-101789
β-strand1027-102939
α-helix1030-10323
β-strand1040-104898
α-helix1055-10573
β-strand1059-106689
β-strand1074-108299
α-helix1083-10897
β-strand1091-109778
α-helix10981
β-strand109919
α-helix1106-111712
α-helix1122-113211
β-strand114517
Chains B, H, I, J, K and L: 54 helices, 25 β-strands
ElementResiduesLengthSheet
α-helix16-3015
α-helix33-353
β-strand41-511110
β-strand58-59210
β-strand60111
β-strand61-63310
β-strand64111
β-strand65-69510
β-strand75-77310
α-helix78-814
α-helix88-9912
α-helix103-12220
α-helix124-13310
α-helix138-15316
β-strand162-1711012
α-helix173-1753
β-strand184-190713
β-strand193-196413
β-strand207-215912
β-strand222-229813
α-helix234-2396
β-strand249-256813
α-helix257-2593
β-strand263-269712
β-strand271113
β-strand282-289812
α-helix297-2993
α-helix300-31314
α-helix314-3196
α-helix332-3365
α-helix341-35313
α-helix358-37013
α-helix378-39417
α-helix404-4096
α-helix415-43420
α-helix436-4394
α-helix445-46723
α-helix474-4763
α-helix477-49822
α-helix500-5089
α-helix512-5143
α-helix520-5234
α-helix531-54616
α-helix547-5515
α-helix552-5543
α-helix564-59027
α-helix595-60814
α-helix609-6135
α-helix617-6204
α-helix627-65832
α-helix672-68918
α-helix696-72833
α-helix735-75723
α-helix760-7623
α-helix765-80844
α-helix814-8163
α-helix825-85026
α-helix853-87119
α-helix872-8765
α-helix882-8854
α-helix899-91719
α-helix918-9203
α-helix925-9295
α-helix932-94514
α-helix948-95811
β-strand972-9811014
β-strand988-9981114
β-strand1010-1017815
β-strand1027-1029315
α-helix1030-10323
β-strand1040-1048914
α-helix1055-10573
β-strand1059-1066815
β-strand1074-1082915
α-helix1083-10897
β-strand1091-1097714
β-strand1099115
α-helix1106-111712
α-helix1122-113110

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein unc-13 homolog A ChimeraA, B, C, D, E, F, G, H, I, J, K, Lprotein1154Rattus norvegicusQ4KUS2 (AlphaFold model)
Sequence of entity 1 (A, B, C, D, E, F, G, H, I, J, K, L), FASTA
>7T7C_1 Protein unc-13 homolog A Chimera (chains A, B, C, D, E, F, G, H, I, J, K, L)
GPLGSEFMAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYC
YECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVL
KDRMKIRERNKPEIFELIQEVFAVTKSAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQG
LQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDD
DIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIK
GEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASN
FGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQ
SPPRASQVVKDCVKACLNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRL
CKSADYMNLHFKVKWLYNEYVAELPTFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGA
LERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIVSKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASGTLK
ELQVKLNNVLDELSHVFATSFQPHIEECVRQMGDILSQVKGTGNVPASACSSVAQDADNV
LQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMERTIVLPPEFLSKLKDHMVRE
EAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLI
KTFVQTQSAQGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFI
EVNIVGPQLSDKKRKFATKSKNNSWAPKYNESFQFSLSADAGPECYELQVCVKDYCFARE
DRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKS
DTRSAEEGGAAPAP

Primary citation

Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release. Grushin, K., Kalyana Sundaram, R.V., Sindelar, C.V. et al. Proc Natl Acad Sci U S A (2022) 119. DOI 10.1073/pnas.2121259119 · PubMed

Other PDB entries of the same protein (UniProt Q4KUS2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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