7T81: Protein unc-13 homolog A

Model of Munc13-1 C1-C2B-MUN-C2C 2D crystal between lipid bilayers. Determined by electron microscopy at 10.0 Å resolution. Released 9 Feb 2022.

Method
Electron microscopy
Resolution
10.0 Å
Organism
Rattus norvegicus
Chains
24
Atoms
216,816
Mol. weight
3141.5 kDa
Released
9 Feb 2022

Explore 7T81 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7T81 contains 1,296 α-helices and 630 β-strands across 24 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C, D, E, F and G: 54 helices, 30 β-strands

ElementResiduesLengthSheet
α-helix16-3015
α-helix36-394
β-strand41-4441
β-strand50-5122
β-strand58-5922
β-strand6013
β-strand6413
β-strand66-6941
β-strand75-7621
α-helix88-9811
α-helix102-12221
α-helix124-13310
α-helix138-15316
β-strand161-171114
α-helix173-1753
β-strand184-19075
β-strand193-19645
α-helix197-1993
β-strand207-216104
β-strand222-22985
α-helix234-2429
β-strand249-25685
α-helix257-2593
β-strand262-26984
α-helix2701
β-strand27115
β-strand282-291104
β-strand29414
α-helix297-2993
α-helix300-31314
α-helix314-3196
α-helix334-3363
α-helix341-35313
α-helix358-37114
α-helix378-39518
α-helix404-4096
α-helix415-43319
α-helix436-4394
α-helix445-46723
α-helix477-50832
α-helix512-5143
α-helix531-54616
α-helix547-5515
α-helix552-5543
α-helix564-59027
α-helix595-61218
α-helix617-6204
α-helix626-65833
β-strand66316
β-strand67116
α-helix672-69120
α-helix696-72833
α-helix735-75723
α-helix760-7623
α-helix765-79228
α-helix794-80815
α-helix814-8163
α-helix825-85026
α-helix853-87119
α-helix872-8765
α-helix880-8812
α-helix882-8865
α-helix899-91719
α-helix918-9203
α-helix925-9295
α-helix932-94514
α-helix948-95811
β-strand96717
β-strand972-981108
β-strand988-998118
β-strand1010-101789
β-strand1027-102939
α-helix1030-10323
β-strand1040-104898
α-helix1055-10573
β-strand1059-106689
β-strand1074-108299
α-helix1083-10897
β-strand1091-109778
α-helix10981
β-strand109919
α-helix1106-111712
α-helix1122-113211
β-strand114517
Chains H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X and Y: 54 helices, 25 β-strands
ElementResiduesLengthSheet
α-helix16-3015
α-helix33-353
β-strand41-511155
β-strand58-59255
β-strand60156
β-strand61-63355
β-strand64156
β-strand65-69555
β-strand75-77355
α-helix78-814
α-helix88-9912
α-helix103-12220
α-helix124-13310
α-helix138-15316
β-strand162-1711057
α-helix173-1753
β-strand184-190758
β-strand193-196458
β-strand207-215957
β-strand222-229858
α-helix234-2396
β-strand249-256858
α-helix257-2593
β-strand263-269757
β-strand271158
β-strand282-289857
α-helix297-2993
α-helix300-31314
α-helix314-3196
α-helix332-3365
α-helix341-35313
α-helix358-37013
α-helix378-39417
α-helix404-4096
α-helix415-43420
α-helix436-4394
α-helix445-46723
α-helix474-4763
α-helix477-49822
α-helix500-5089
α-helix512-5143
α-helix520-5234
α-helix531-54616
α-helix547-5515
α-helix552-5543
α-helix564-59027
α-helix595-60814
α-helix609-6135
α-helix617-6204
α-helix627-65832
α-helix672-68918
α-helix696-72833
α-helix735-75723
α-helix760-7623
α-helix765-80844
α-helix814-8163
α-helix825-85026
α-helix853-87119
α-helix872-8765
α-helix882-8854
α-helix899-91719
α-helix918-9203
α-helix925-9295
α-helix932-94514
α-helix948-95811
β-strand972-9811059
β-strand988-9981159
β-strand1010-1017860
β-strand1027-1029360
α-helix1030-10323
β-strand1040-1048959
α-helix1055-10573
β-strand1059-1066860
β-strand1074-1082960
α-helix1083-10897
β-strand1091-1097759
β-strand1099160
α-helix1106-111712
α-helix1122-113110

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein unc-13 homolog AA, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Yprotein1154Rattus norvegicusQ4KUS2 (AlphaFold model), Q62768 (AlphaFold model)
Sequence of entity 1 (A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y), FASTA
>7T81_1 Protein unc-13 homolog A (chains A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y)
GPLGSEFMAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYC
YECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVL
KDRMKIRERNKPEIFELIQEVFAVTKSAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQG
LQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDD
DIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIK
GEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASN
FGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQ
SPPRASQVVKDCVKACLNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRL
CKSADYMNLHFKVKWLYNEYVAELPTFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGA
LERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIVSKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASGTLK
ELQVKLNNVLDELSHVFATSFQPHIEECVRQMGDILSQVKGTGNVPASACSSVAQDADNV
LQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMERTIVLPPEFLSKLKDHMVRE
EAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLI
KTFVQTQSAQGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFI
EVNIVGPQLSDKKRKFATKSKNNSWAPKYNESFQFSLSADAGPECYELQVCVKDYCFARE
DRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKS
DTRSAEEGGAAPAP

Primary citation

Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release. Grushin, K., Kalyana Sundaram, R.V., Sindelar, C.V. et al. Proc Natl Acad Sci U S A (2022) 119. DOI 10.1073/pnas.2121259119 · PubMed

Other PDB entries of the same protein (UniProt Q4KUS2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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