7TOP: Yeast 80S ribosome
Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20. Determined by electron microscopy at 2.4 Å resolution. Released 25 May 2022.
- Method
- Electron microscopy
- Resolution
- 2.4 Å
- Organisms
- Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
- Chains
- 48
- Atoms
- 125,433
- Mol. weight
- 1997.88 kDa
- Ligands
- ZN
- Released
- 25 May 2022
Explore 7TOP in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7TOP contains 302 α-helices and 280 β-strands across 44 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain AL02: 9 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-9 | 4 | |
| α-helix | 10-12 | 3 | |
| α-helix | 29-31 | 3 | |
| β-strand | 40-49 | 10 | 6 |
| α-helix | 50-51 | 2 | |
| β-strand | 58-64 | 7 | 6 |
| β-strand | 71-77 | 7 | 6 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 7 |
| β-strand | 83 | 1 | 8 |
| β-strand | 87-91 | 5 | 6 |
| β-strand | 101-103 | 3 | 6 |
| α-helix | 104-106 | 3 | |
| β-strand | 112-114 | 3 | 6 |
| β-strand | 116 | 1 | 9 |
| β-strand | 126 | 1 | 9 |
| β-strand | 134-136 | 3 | 6 |
| β-strand | 145-149 | 5 | 6 |
| β-strand | 155-159 | 5 | 6 |
| β-strand | 163-166 | 4 | 6 |
| β-strand | 169 | 1 | 7 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-189 | 8 | |
| α-helix | 201-203 | 3 | |
| β-strand | 224-225 | 2 | 10 |
| β-strand | 237-238 | 2 | 10 |
Chain AL03: 17 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-16 | 3 | |
| α-helix | 27-28 | 2 | |
| α-helix | 33-35 | 3 | |
| β-strand | 42-43 | 2 | 13 |
| β-strand | 45-59 | 15 | 14 |
| β-strand | 71-80 | 10 | 14 |
| α-helix | 82-83 | 2 | |
| β-strand | 84-96 | 13 | 15 |
| β-strand | 98-106 | 9 | 15 |
| α-helix | 112-115 | 4 | |
| α-helix | 116-118 | 3 | |
| α-helix | 133-136 | 4 | |
| α-helix | 142-153 | 12 | |
| β-strand | 157-163 | 7 | 15 |
| α-helix | 166-168 | 3 | |
| β-strand | 178-182 | 5 | 15 |
| β-strand | 183-184 | 2 | 13 |
| α-helix | 188-197 | 10 | |
| β-strand | 199 | 1 | 15 |
| β-strand | 202-203 | 2 | 15 |
| α-helix | 205-207 | 3 | |
| β-strand | 214-220 | 7 | 14 |
| α-helix | 221-222 | 2 | |
| β-strand | 223-227 | 5 | 16 |
| α-helix | 229-233 | 5 | |
| α-helix | 235-239 | 5 | |
| β-strand | 268-271 | 4 | 16 |
| β-strand | 274-286 | 13 | 14 |
| α-helix | 307 | 1 | |
| β-strand | 311 | 1 | 17 |
| β-strand | 315 | 1 | 17 |
| β-strand | 321-325 | 5 | 14 |
| β-strand | 335-340 | 6 | 14 |
| α-helix | 352-354 | 3 | |
| β-strand | 356-359 | 4 | 14 |
| α-helix | 373-380 | 8 | |
Chain AL04: 23 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-9 | 4 | 18 |
| β-strand | 15-20 | 6 | 18 |
| α-helix | 32-42 | 11 | |
| α-helix | 47-49 | 3 | |
| β-strand | 63-64 | 2 | 19 |
| β-strand | 75-76 | 2 | 19 |
| β-strand | 88 | 1 | 19 |
| α-helix | 98-99 | 2 | |
| α-helix | 115-126 | 12 | |
| α-helix | 127-129 | 3 | |
| α-helix | 133-137 | 5 | |
| β-strand | 150-152 | 3 | 18 |
| α-helix | 154-156 | 3 | |
| α-helix | 162-171 | 10 | |
| α-helix | 175-180 | 6 | |
| β-strand | 186-187 | 2 | 20 |
| α-helix | 191-195 | 5 | |
| β-strand | 199-200 | 2 | 20 |
| β-strand | 206-209 | 4 | 18 |
| α-helix | 215-218 | 4 | |
| β-strand | 226-229 | 4 | 18 |
| α-helix | 235-238 | 4 | |
| α-helix | 240-242 | 3 | |
| β-strand | 248-251 | 4 | 18 |
| α-helix | 252-262 | 11 | |
| α-helix | 276-279 | 4 | |
| α-helix | 286-291 | 6 | |
| α-helix | 295-298 | 4 | |
| α-helix | 300-302 | 3 | |
| α-helix | 314-316 | 3 | |
| α-helix | 321-326 | 6 | |
| α-helix | 330-336 | 7 | |
| α-helix | 342-345 | 4 | |
| α-helix | 353-359 | 7 | |
Chain AL05: 18 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-14 | 5 | |
| α-helix | 22-25 | 4 | |
| α-helix | 30-37 | 8 | |
| α-helix | 38-40 | 3 | |
| β-strand | 50-56 | 7 | 22 |
| β-strand | 59-66 | 8 | 22 |
| β-strand | 73-79 | 7 | 22 |
| α-helix | 80-82 | 3 | |
| α-helix | 83-86 | 4 | |
| α-helix | 95-112 | 18 | |
| α-helix | 133-135 | 3 | |
| α-helix | 139-142 | 4 | |
| β-strand | 143 | 1 | 23 |
| β-strand | 145-147 | 3 | 22 |
| α-helix | 159-169 | 11 | |
| β-strand | 172 | 1 | 23 |
| α-helix | 177-179 | 3 | |
| β-strand | 184 | 1 | 24 |
| β-strand | 189 | 1 | 24 |
| α-helix | 192-199 | 8 | |
| α-helix | 202-209 | 8 | |
| α-helix | 224-228 | 5 | |
| α-helix | 236-249 | 14 | |
| α-helix | 262-269 | 8 | |
| α-helix | 274-277 | 4 | |
| α-helix | 279-292 | 14 | |
Chain AL06: 7 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-12 | 3 | |
| α-helix | 15-19 | 5 | |
| β-strand | 38-42 | 5 | 26 |
| β-strand | 51-57 | 7 | 26 |
| β-strand | 62-66 | 5 | 26 |
| α-helix | 69-72 | 4 | |
| β-strand | 77-80 | 4 | 26 |
| α-helix | 81-83 | 3 | |
| β-strand | 84-90 | 7 | 26 |
| α-helix | 98-100 | 3 | |
| α-helix | 133-149 | 17 | |
| α-helix | 155-159 | 5 | |
Chain AL07: 12 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-71 | 44 | |
| β-strand | 74-77 | 4 | 28 |
| α-helix | 78-81 | 4 | |
| β-strand | 83-88 | 6 | 29 |
| α-helix | 97-105 | 9 | |
| β-strand | 110 | 1 | 30 |
| β-strand | 113-118 | 6 | 29 |
| α-helix | 121-129 | 9 | |
| α-helix | 131-133 | 3 | |
| β-strand | 134-137 | 4 | 29 |
| α-helix | 141-151 | 11 | |
| β-strand | 153-156 | 4 | 31 |
| β-strand | 159-162 | 4 | 31 |
| α-helix | 166-173 | 8 | |
| α-helix | 174-176 | 3 | |
| α-helix | 181-189 | 9 | |
| α-helix | 195-201 | 7 | |
| β-strand | 202 | 1 | 31 |
| α-helix | 203-204 | 2 | |
| β-strand | 205-206 | 2 | 29 |
| β-strand | 222 | 1 | 32 |
| β-strand | 229 | 1 | 32 |
| β-strand | 230-231 | 2 | 29 |
| α-helix | 236-243 | 8 | |
Chain AL08: 18 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-49 | 3 | |
| β-strand | 51 | 1 | 34 |
| α-helix | 54-68 | 15 | |
| β-strand | 70-71 | 2 | 35 |
| α-helix | 81-83 | 3 | |
| α-helix | 84-94 | 11 | |
| α-helix | 95-97 | 3 | |
| α-helix | 98-100 | 3 | |
| α-helix | 102-112 | 11 | |
| α-helix | 127-129 | 3 | |
| β-strand | 133 | 1 | 36 |
| α-helix | 136-144 | 9 | |
| β-strand | 150-154 | 5 | 36 |
| α-helix | 160-162 | 3 | |
| α-helix | 165-173 | 9 | |
| β-strand | 177-180 | 4 | 36 |
| α-helix | 183-189 | 7 | |
| β-strand | 197-200 | 4 | 36 |
| α-helix | 205-207 | 3 | |
| α-helix | 208-218 | 11 | |
| α-helix | 219-223 | 5 | |
| α-helix | 226-229 | 4 | |
| β-strand | 234-235 | 2 | 35 |
| α-helix | 237-239 | 3 | |
| α-helix | 240-250 | 11 | |
Chain AL09: 4 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-11 | 9 | 39 |
| β-strand | 17-21 | 5 | 40 |
| β-strand | 24-29 | 6 | 40 |
| β-strand | 32-36 | 5 | 40 |
| β-strand | 44-47 | 4 | 39 |
| β-strand | 52-60 | 9 | 39 |
| α-helix | 62-83 | 22 | |
| β-strand | 86-93 | 8 | 41 |
| β-strand | 100-103 | 4 | 42 |
| β-strand | 111-115 | 5 | 42 |
| α-helix | 117-119 | 3 | |
| β-strand | 124-127 | 4 | 42 |
| α-helix | 128-129 | 2 | |
| β-strand | 133-136 | 4 | 41 |
| β-strand | 143-148 | 6 | 41 |
| α-helix | 151-164 | 14 | |
| β-strand | 178-185 | 8 | 41 |
36 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 25S rRNA | A25S | RNA | 3396 | Saccharomyces cerevisiae | |
| 5.8S rRNA | A58S | RNA | 158 | Saccharomyces cerevisiae | |
| 5S rRNA | A5S | RNA | 121 | Saccharomyces cerevisiae | |
| 60S ribosomal protein L2-A | AL02 | protein | 254 | Saccharomyces cerevisiae | P0CX45 (AlphaFold model) |
| RPL3 isoform 1 | AL03 | protein | 387 | Saccharomyces cerevisiae | P14126 (AlphaFold model) |
| RPL4A isoform 1 | AL04 | protein | 362 | Saccharomyces cerevisiae | P10664 (AlphaFold model) |
| RPL5 isoform 1 | AL05 | protein | 297 | Saccharomyces cerevisiae | P26321 (AlphaFold model) |
| 60S ribosomal protein L6-A | AL06 | protein | 176 | Saccharomyces cerevisiae | Q02326 |
| 60S ribosomal protein L7-A | AL07 | protein | 244 | Saccharomyces cerevisiae | P05737 |
| 60S ribosomal protein L8-A | AL08 | protein | 256 | Saccharomyces cerevisiae | P17076 |
| 60S ribosomal protein L9-A | AL09 | protein | 191 | Saccharomyces cerevisiae | P05738 |
| RPL10 isoform 1 | AL10 | protein | 221 | Saccharomyces cerevisiae | P41805 |
36 more molecules are not listed.
Sequence of entity 1 (A25S), FASTA
>7TOP_1 25S rRNA (chains A25S)
GUUUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGA
AAAGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUG
AAAUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCC
UUGUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGU
GCGGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGG
GUGGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUG
AUGGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGG
GAAGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUC
UCGCAUUUCACUGGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCU
UGCCUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACG
UAAGUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGA
GUCUAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUA
GGUUGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGA
GUAAGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCC
AGAGGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUG
GGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCU
CAGGAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGG
GUCGAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAA
UUGAACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGG
CGAUGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCA
CAAAAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAA
GGAGUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGC
GUGUUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGG
AGGUCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUG
GUGGUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACG
UCAACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAG
GCCUGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAU
AUGGAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAG
UUAUCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUU
AUGGCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAA
UCCACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAG
GUGAACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGU
AACUUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGC
GGGCGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCU
UGUUGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAA
CUUAGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUG
GUCAGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAA
GAAAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAA
AUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCU
AUCUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAG
AAGACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAU
AAGUGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAA
UGAAGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGA
UCCGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGA
UAACGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGG
UAAAAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUC
GAUCCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAA
CUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCU
CUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGA
ACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUA
CCGCAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGC
GGCUGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUC
UAAGUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUA
CGAAUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGC
GGAAAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAU
UUGUAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUAC
GAUCUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU
Sequence of entity 2 (A58S), FASTA
>7TOP_2 5.8S rRNA (chains A58S)
AAACUUUCAACAACGGAUCUCUUGGUUCUCGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
ACGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCC
UUGGUAUUCCAGGGGGCAUGCCUGUUUGAGCGUCAUUU
Sequence of entity 3 (A5S), FASTA
>7TOP_3 5S rRNA (chains A5S)
GGUUGCGGCCAUAUCUACCAGAAAGCACCGUUUCCCGUCCGAUCAACUGUAGUUAAGCUG
GUAAGAGCCUGACCGAGUAGUGUAGUGGGUGACCAUACGCGAAACUCAGGUGCUGCAAUC
U
Sequence of entity 4 (AL02), FASTA
>7TOP_4 60S ribosomal protein L2-A (chains AL02)
MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAK
VVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKP
GDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLL
KAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAA
RRTGLLRGSQKTQD
Sequence of entity 5 (AL03), FASTA
>7TOP_5 RPL3 isoform 1 (chains AL03)
MSHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDL
DRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYK
NWYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVLVHTQIRKTPLAQKKAHLAE
IQLNGGSISEKVDWAREHFEKTVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPR
KTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDR
TKKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWID
TASKFGKGRFQTPAEKHAFMGTLKKDL
Sequence of entity 6 (AL04), FASTA
>7TOP_6 RPL4A isoform 1 (chains AL04)
MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQT
SAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRY
ATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLK
VLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAP
GAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIR
PAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFTETLK
HD
Sequence of entity 7 (AL05), FASTA
>7TOP_7 RPL5 isoform 1 (chains AL05)
MAFQKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVVRFTNKDI
ICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGLLIARRTLQKLGLDETYK
GVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGALKGASDGGLYVPHSENRF
PGWDFETEEIDPELLRSYIFGGHVSQYMEELADDDEERFSELFKGYLADDIDADSLEDIY
TSAHEAIRADPAFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ
Sequence of entity 8 (AL06), FASTA
>7TOP_8 60S ribosomal protein L6-A (chains AL06)
MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLED
NTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEAN
LFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDKPHMLKF
Sequence of entity 9 (AL07), FASTA
>7TOP_9 60S ribosomal protein L7-A (chains AL07)
MAAEKILTPESQLKKSKAQQKTAEQVAAERAARKAANKEKRAIILERNAAYQKEYETAER
NIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVT
KATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILS
IDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLV
KSMN
Sequence of entity 10 (AL08), FASTA
>7TOP_10 60S ribosomal protein L8-A (chains AL08)
MAPGKKVAPAPFGAKSTKSNKTRNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQR
QKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGK
SKQDASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIV
KGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGN
KAQAKMDKRAKNSDSA
Sequence of entity 11 (AL09), FASTA
>7TOP_11 60S ribosomal protein L9-A (chains AL09)
MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNG
GRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGD
KKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIY
VSHKGFITEDL
Sequence of entity 12 (AL10), FASTA
>7TOP_12 RPL10 isoform 1 (chains AL10)
MARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKATVDEFPLCVHLVSNELEQL
SSEALEAARICANKYMTTVSGRDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWG
KPHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPGQQKIILSKKWGFTNLDRPE
YLKKREAGEVKDDGAFVKFLSKKGSLENNIREFPEYFAAQA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
Primary citation
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Loveland, A.B., Svidritskiy, E., Susorov, D. et al. Nat Commun (2022) 13:2776-2776. DOI 10.1038/s41467-022-30418-0 · PubMed
Other PDB entries of the same protein (UniProt P0CX45 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9PN5 1.75 Å, Composite map of hypomethylated 80S ribosome treated with hygromycin B
- 8CCS 1.97 Å, 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex
- 8CDR 2.04 Å, Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2…
- 8CEH 2.05 Å, Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2…
- 8P8N 2.15 Å, Mouse RPL39 integrated into the yeast 60S ribosomal subunit
- 8PFR 2.15 Å, Mouse RPL39L integrated into the yeast 60S ribosomal subunit
- 8EVT 2.2 Å, Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome…
- 8T2Y 2.2 Å, Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA,…
- 8P8U 2.23 Å, Yeast 60S ribosomal subunit
- 8CGN 2.28 Å, Non-rotated 80S S. cerevisiae ribosome with ligands
- 8ZHC 2.3 Å, pre-frameshift complex of yeast 80S ribosome with eRF1 and mRNA of WNV
- 7UOO 2.34 Å, Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state
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